Search: WFRF:(Fernandez Reyes Delmiro)
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Affinity Proteomics...
Affinity Proteomics Reveals Elevated Muscle Proteins in Plasma of Children with Cerebral Malaria
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- Bachmann, Julie (author)
- KTH,Science for Life Laboratory, SciLifeLab
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Burte, Florence (author)
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Pramana, Setia (author)
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Conte, Ianina (author)
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Brown, Biobele J. (author)
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Orimadegun, Adebola E. (author)
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Ajetunmobi, Wasiu A. (author)
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Afolabi, Nathaniel K. (author)
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Akinkunmi, Francis (author)
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Omokhodion, Samuel (author)
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Akinbami, Felix O. (author)
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Shokunbi, Wuraola A. (author)
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- Kampf, Caroline (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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- Pawitan, Yudi (author)
- Karolinska Institutet
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- Uhlén, Mathias (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab
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Sodeinde, Olugbemiro (author)
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- Schwenk, Jochen M. (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab
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- Wahlgren, Mats (author)
- Karolinska Institutet
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Fernandez-Reyes, Delmiro (author)
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- Nilsson, Peter (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab
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(creator_code:org_t)
- 2014-04-17
- 2014
- English.
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In: PLoS Pathogens. - : Public Library of Science (PLoS). - 1553-7366 .- 1553-7374. ; 10:4, s. e1004038-
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Systemic inflammation and sequestration of parasitized erythrocytes are central processes in the pathophysiology of severe Plasmodium falciparum childhood malaria. However, it is still not understood why some children are more at risks to develop malaria complications than others. To identify human proteins in plasma related to childhood malaria syndromes, multiplex antibody suspension bead arrays were employed. Out of the 1,015 proteins analyzed in plasma from more than 700 children, 41 differed between malaria infected children and community controls, whereas 13 discriminated uncomplicated malaria from severe malaria syndromes. Markers of oxidative stress were found related to severe malaria anemia while markers of endothelial activation, platelet adhesion and muscular damage were identified in relation to children with cerebral malaria. These findings suggest the presence of generalized vascular inflammation, vascular wall modulations, activation of endothelium and unbalanced glucose metabolism in severe malaria. The increased levels of specific muscle proteins in plasma implicate potential muscle damage and microvasculature lesions during the course of cerebral malaria.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Bachmann, Julie
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Burte, Florence
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Pramana, Setia
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Conte, Ianina
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Brown, Biobele J ...
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Orimadegun, Adeb ...
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show more...
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Ajetunmobi, Wasi ...
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Afolabi, Nathani ...
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Akinkunmi, Franc ...
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Omokhodion, Samu ...
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Akinbami, Felix ...
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Shokunbi, Wuraol ...
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Kampf, Caroline
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Pawitan, Yudi
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Uhlén, Mathias
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Sodeinde, Olugbe ...
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Schwenk, Jochen ...
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Wahlgren, Mats
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Fernandez-Reyes, ...
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Nilsson, Peter
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
- Articles in the publication
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PLoS Pathogens
- By the university
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Royal Institute of Technology
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Karolinska Institutet
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Uppsala University