WFRF:(Ferrazzo Teresa)
Search: WFRF:(Ferrazzo Teresa) > (2024) > Multicancer screeni...
- 1 of 1
- Previous record
- Next record
- To hitlist
Multicancer screening test based on the detection of circulating non haematological proliferating atypical cells
-
- Malara, Natalia (author)
- Magna Graecia Univ Catanzaro, Italy
-
- Coluccio, Maria Laura (author)
- Magna Graecia Univ Catanzaro, Italy
-
- Grillo, Fabiana (author)
- Univ Leicester, England
- show more...
- show less...
- (creator_code:org_t)
- BMC, 2024
- 2024
- English.
- In: Molecular Cancer. - : BMC. - 1476-4598. ; 23:1
- Journal article (other academic/artistic)
Abstract
Subject headings
Close
- Background the problem in early diagnosis of sporadic cancer is understanding the individual's risk to develop disease. In response to this need, global scientific research is focusing on developing predictive models based on non-invasive screening tests. A tentative solution to the problem may be a cancer screening blood-based test able to discover those cell requirements triggering subclinical and clinical onset latency, at the stage when the cell disorder, i.e. atypical epithelial hyperplasia, is still in a subclinical stage of proliferative dysregulation. Methods a well-established procedure to identify proliferating circulating tumor cells was deployed to measure the cell proliferation of circulating non-haematological cells which may suggest tumor pathology. Moreover, the data collected were processed by a supervised machine learning model to make the prediction. Results the developed test combining circulating non-haematological cell proliferation data and artificial intelligence shows 98.8% of accuracy, 100% sensitivity, and 95% specificity. Conclusion this proof of concept study demonstrates that integration of innovative non invasive methods and predictive-models can be decisive in assessing the health status of an individual, and achieve cutting-edge results in cancer prevention and management.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Cancer prevention; Liquid biopsy; Multicancer diagnosis; Non heamatological proliferating cells; Predictive model; Supervised machine learning; Neural network algorithm
Publication and Content Type
- vet (subject category)
- art (subject category)
Find in a library
- Molecular Cancer (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Malara, Natalia
- Coluccio, Maria ...
- Grillo, Fabiana
- Ferrazzo, Teresa
- Garo, Nastassia ...
- Donato, Giuseppe
- show more...
- Lavecchia, Annam ...
- Fulciniti, Franc ...
- Sapino, Anna
- Cascardi, Eliano
- Pellegrini, Anto ...
- Foxi, Prassede
- Furlanello, Cesa ...
- Negri, Giovanni
- Fadda, Guido
- Capitanio, Arrig ...
- Pullano, Salvato ...
- Garo, Virginia M ...
- Ferrazzo, France ...
- Lowe, Alarice
- Torsello, Angela
- Candeloro, Patri ...
- Gentile, Frances ...
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Cancer and Oncol ...
- Articles in the publication
- Molecular Cancer
- By the university
- Linköping University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
