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Ambulatory blood pressure monitoring for risk stratification in obese and non-obese subjects from 10 populations

Hansen, T. W. (author)
Thijs, L. (author)
Li, Y. (author)
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Boggia, J. (author)
Liu, Y. (author)
Asayama, K. (author)
Kikuya, M. (author)
Björklund-Bodegård, Kristina (author)
Uppsala universitet,Geriatrik
Ohkubo, T. (author)
Jeppesen, J. (author)
Torp-Pedersen, C. (author)
Dolan, E. (author)
Kuznetsova, T. (author)
Stolarz-Skrzypek, K. (author)
Tikhonoff, V. (author)
Malyutina, S. (author)
Casiglia, E. (author)
Nikitin, Y. (author)
Lind, Lars (author)
Uppsala universitet,Geriatrik
Sandoya, E. (author)
Kawecka-Jaszcz, K. (author)
Filipovsky, J. (author)
Imai, Y. (author)
Wang, J. (author)
O'Brien, E. (author)
Staessen, J. A. (author)
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 (creator_code:org_t)
2014-01-16
2014
English.
In: Journal of Human Hypertension. - : Springer Science and Business Media LLC. - 0950-9240 .- 1476-5527. ; 28:9, s. 535-542
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Overweight clusters with high blood pressure (BP), but the independent contribution of both risk factors remains insufficiently documented. In a prospective population study involving 8467 participants (mean age 54.6 years; 47.0% women) randomly recruited from 10 populations, we studied the contribution of body mass index (BMI) to risk over and beyond BP, taking advantage of the superiority of ambulatory over conventional BP. Over 10.6 years (median), 1271 participants (15.0%) died and 1092 (12.9%), 637 (7.5%) and 443 (5.2%) experienced a fatal or nonfatal cardiovascular, cardiac or cerebrovascular event. Adjusted for sex and age, low BMI (<20.7 kg m(-2)) predicted death (hazard ratio (HR) vs average risk, 1.52; P<0.0001) and high BMI (>= 30.9 kg m(-2)) predicted the cardiovascular end point (HR, 1.27; P = 0.006). With adjustments including 24-h systolic BP, these HRs were 1.50 (P <0.001) and 0.98 (P = 0.91), respectively. Across quartiles of the BMI distribution, 24-h and nighttime systolic BP predicted every end point (1.13 <= standardized HR <= 1.67; 0.046 <= P<0.0001). The interaction between systolic BP and BMI was nonsignificant (P >= 0.22). Excluding smokers removed the contribution of BMI categories to the prediction of mortality. In conclusion, BMI only adds to BP in risk stratification for mortality but not for cardiovascular outcomes. Smoking probably explains the association between increased mortality and low BMI.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Keyword

ambulatory blood pressure
body mass index
population science
risk factors
epidemiology

Publication and Content Type

ref (subject category)
art (subject category)

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