SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Finnila Mikko A. J.)
 

Sökning: WFRF:(Finnila Mikko A. J.) > (2021) > Endocrine, metaboli...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006557naa a2200637 4500
001oai:DiVA.org:uu-447923
003SwePub
008210823s2021 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:146778306
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4479232 URI
0247 a https://doi.org/10.1016/j.reprotox.2021.04.0042 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1467783062 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Alarcon, Soniau Univ Miguel Hernandez Elche, Inst Bioingn, Elche, Alicante, Spain.;Karolinska Inst, Inst Environm Med, Stockholm, Sweden4 aut
2451 0a Endocrine, metabolic and apical effects of in utero and lactational exposure to non-dioxin-like 2,2 ',3,4,4 ',5,5 '-heptachlorobiphenyl (PCB 180) :b A postnatal follow-up study in rats
264 1b Elsevier,c 2021
338 a electronic2 rdacarrier
520 a PCB 180 is a persistent and abundant non-dioxin-like PCB (NDL-PCB). We determined the developmental toxicity profile of ultrapure PCB 180 in developing offspring following in utero and lactational exposure with the focus on endocrine, metabolic and retinoid system alterations. Pregnant rats were given total doses of 0, 10, 30, 100, 300 or 1000 mg PCB 180/kg bw on gestational days 7-10 by oral gavage, and the offspring were sampled on postnatal days (PND) 7, 35 and 84. Decreased serum testosterone and triiodothyronine concentrations on PND 84, altered liver retinoid levels, increased liver weights and induced 7-pentoxyresorufin O-dealkylase (PROD) activity were the sensitive effects used for margin of exposure (MoE) calculations. Liver weights were increased together with induction of the metabolizing enzymes cytochrome P450 (CYP) 2B1, CYP3A1, and CYP1A1. Less sensitive effects included decreased serum estradiol and increased luteinizing hormone levels in females, decreased prostate and seminal vesicle weight and increased pituitary weight in males, increased cortical bone area and thickness of tibial diaphysis in females and decreased cortical bone mineral density in males. Developmental toxicity profiles were partly different in male and female offspring, males being more sensitive to increased liver weight, PROD induction and decreased thyroxine concentrations. MoE assessment indicated that the 95th percentile of current maternal PCB 180 concentrations do not exceed the estimated tolerable human lipid-based PCB 180 concentration. Although PCB 180 is much less potent than dioxin-like compounds, it shares several toxicological targets suggesting a potential for interactions.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng
653 a PCB 180
653 a Non-dioxin-like PCBs
653 a Testosterone
653 a Thyroid hormones
653 a Retinoid
653 a Endocrine disruption
653 a Liver
7001 a Esteban, Javieru Univ Miguel Hernandez Elche, Inst Bioingn, Elche, Alicante, Spain4 aut
7001 a Roos, Robertu Karolinska Inst, Inst Environm Med, Stockholm, Sweden.;Grand Duchy Luxembourg, Lab & Mine Inspect, Minist Work, Luxembourg, Luxembourg4 aut
7001 a Heikkinen, Paiviu Finnish Inst Hlth & Welf THL, Environm Hlth Unit, POB 95, FI-70701 Kuopio, Finland4 aut
7001 a Sanchez-Perez, Ismaelu Univ Miguel Hernandez Elche, Inst Bioingn, Elche, Alicante, Spain4 aut
7001 a Adamsson, Annikau Univ Turku, Turku Univ Hosp, Inst Biomed, Dept Paediat,Res Ctr Integrat Physiol & Pharmac, FI-20520 Turku, Finland.;Univ Turku, Turku Univ Hosp, Inst Biomed, Dept Paediat,Ctr Populat Hlth Res, FI-20520 Turku, Finland,Univ Oulu, Fac Med, Res Unit Med Imaging Phys & Technol, Oulu, Finland,Vrije Univ Amsterdam, Dept Environm & Hlth, De Boelelaan 1108, NL-1081 HZ Amsterdam, Netherlands4 aut
7001 a Toppari, Jormau Univ Turku, Turku Univ Hosp, Inst Biomed, Dept Paediat,Res Ctr Integrat Physiol & Pharmac, FI-20520 Turku, Finland.;Univ Turku, Turku Univ Hosp, Inst Biomed, Dept Paediat,Ctr Populat Hlth Res, FI-20520 Turku, Finland4 aut
7001 a Koskela, Anttiu Univ Oulu, Inst Canc Res & Translat Med, Dept Anat & Cell Biol, Oulu, Finland4 aut
7001 a Finnila, Mikko A. J.u Univ Oulu, Fac Med, Res Unit Med Imaging Phys & Technol, Oulu, Finland4 aut
7001 a Tuukkanen, Juhau Univ Oulu, Inst Canc Res & Translat Med, Dept Anat & Cell Biol, Oulu, Finland4 aut
7001 a Herlin, Mariau Karolinska Inst, Inst Environm Med, Stockholm, Sweden4 aut
7001 a Hamscher, Gerdu Justus Liebig Univ, Inst Food Chem & Food Biotechnol, D-35392 Giessen, Germany4 aut
7001 a Leslie, Heather A.u Vrije Univ Amsterdam, Dept Environm & Hlth, De Boelelaan 1108, NL-1081 HZ Amsterdam, Netherlands4 aut
7001 a Korkalainen, Merjau Finnish Inst Hlth & Welf THL, Environm Hlth Unit, POB 95, FI-70701 Kuopio, Finland4 aut
7001 a Halldin, Kristeru Uppsala universitet,Institutionen för kemi - BMC,Karolinska Inst, Inst Environm Med, Stockholm, Sweden4 aut0 (Swepub:uu)krishall
7001 a Schrenk, Dieteru Univ Kaiserslautern, Food Chem & Toxicol, D-67663 Kaiserslautern, Germany4 aut
7001 a Hakansson, Helenu Karolinska Institutet,Karolinska Inst, Inst Environm Med, Stockholm, Sweden4 aut
7001 a Viluksela, Mattiu Univ Eastern Finland, Sch Pharm Toxicol, Dept Environm & Biol Sci, Kuopio, Finland.;Uppsala Univ, BMC, Off Med & Pharm, SE-75123 Uppsala, Sweden4 aut
7102 a Univ Miguel Hernandez Elche, Inst Bioingn, Elche, Alicante, Spain.;Karolinska Inst, Inst Environm Med, Stockholm, Swedenb Univ Miguel Hernandez Elche, Inst Bioingn, Elche, Alicante, Spain4 org
7730 t Reproductive Toxicologyd : Elsevierg 102, s. 109-127q 102<109-127x 0890-6238x 1873-1708
8564 u https://doi.org/10.1016/j.reprotox.2021.04.004y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1587086/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://doi.org/10.1016/j.reprotox.2021.04.004
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-447923
8564 8u https://doi.org/10.1016/j.reprotox.2021.04.004
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:146778306

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy