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Sökning: onr:"swepub:oai:DiVA.org:uu-282631" > PET-CT for staging ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005159naa a2200613 4500
001oai:DiVA.org:uu-282631
003SwePub
008160406s2016 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:c59a5d62-0980-4441-854b-3771fa0a0bb7
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2826312 URI
0247 a https://doi.org/10.1182/blood-2015-11-6794072 DOI
0247 a https://lup.lub.lu.se/record/85925502 URI
040 a (SwePub)uud (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Barrington, Sally Fu King's College London4 aut
2451 0a PET-CT for staging and early response :b results from the Response-Adapted Therapy in Advanced Hodgkin Lymphoma study.
264 1b American Society of Hematology,c 2016
338 a print2 rdacarrier
520 a International guidelines recommend that positron emission tomography-computed tomography (PET-CT) should replace CT in Hodgkin lymphoma (HL). The aims of this study were to compare PET-CT with CT for staging and measure agreement between expert and local readers, using a 5-point scale (Deauville criteria), to adapt treatment in a clinical trial: Response-Adapted Therapy in Advanced Hodgkin Lymphoma (RATHL). Patients were staged using clinical assessment, CT, and bone marrow biopsy (RATHL stage). PET-CT was performed at baseline (PET0) and after 2 chemotherapy cycles (PET2) in a response-adapted design. PET-CT was reported centrally by experts at 5 national core laboratories. Local readers optionally scored PET2 scans. The RATHL and PET-CT stages were compared. Agreement among experts and between expert and local readers was measured. RATHL and PET0 stage were concordant in 938 (80%) patients. PET-CT upstaged 159 (14%) and downstaged 74 (6%) patients. Upstaging by extranodal disease in bone marrow (92), lung (11), or multiple sites (12) on PET-CT accounted for most discrepancies. Follow-up of discrepant findings confirmed the PET characterization of lesions in the vast majority. Five patients were upstaged by marrow biopsy and 7 by contrast-enhanced CT in the bowel and/or liver or spleen. PET2 agreement among experts (140 scans) with a κ (95% confidence interval) of 0.84 (0.76-0.91) was very good and between experts and local readers (300 scans) at 0.77 (0.68-0.86) was good. These results confirm PET-CT as the modern standard for staging HL and that response assessment using Deauville criteria is robust, enabling translation of RATHL results into clinical practice.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng
7001 a Kirkwood, Amy Au University College London4 aut
7001 a Franceschetto, Antonellau University of Modena and Reggio Emilia4 aut
7001 a Fulham, Michael Ju Royal Prince Alfred Hospital4 aut
7001 a Roberts, Thomas Hu University College London4 aut
7001 a Almquist, Helénu Lund University,Lunds universitet,Klinisk fysiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Physiology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)extLU-691
7001 a Brun, Evau Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-ebr
7001 a Hjorthaug, Karinu Aarhus University Hospital4 aut
7001 a Viney, Zaid Nu Guy's and St Thomas' NHS Foundation Trust4 aut
7001 a Pike, Lucy Cu King's College London4 aut
7001 a Federico, Massimou University of Modena and Reggio Emilia4 aut
7001 a Luminari, Stefanou University of Modena and Reggio Emilia4 aut
7001 a Radford, John4 aut
7001 a Trotman, Judith4 aut
7001 a Fosså, Alexander4 aut
7001 a Berkahn, Leanne4 aut
7001 a Molin, Danielu Uppsala universitet,Experimentell och klinisk onkologi4 aut0 (Swepub:uu)danimoli
7001 a D'Amore, Francesco4 aut
7001 a Sinclair, Donald A4 aut
7001 a Smith, Paul4 aut
7001 a O'Doherty, Michael J4 aut
7001 a Stevens, Lindsey4 aut
7001 a Johnson, Peter W4 aut
7102 a King's College Londonb University College London4 org
7730 t Bloodd : American Society of Hematologyg 127:12, s. 1531-1538q 127:12<1531-1538x 0006-4971x 1528-0020
8564 u https://kclpure.kcl.ac.uk/portal/files/51820460/Barrington_blood_2015_11_679407.full.pdf
8564 u http://www.ncbi.nlm.nih.gov/pubmed/26747247?dopt=Abstracty FULLTEXT
8564 u http://dx.doi.org/10.1182/blood-2015-11-679407y FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-282631
8564 8u https://doi.org/10.1182/blood-2015-11-679407
8564 8u https://lup.lub.lu.se/record/8592550

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