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Prediction of activ...
Prediction of activation patterns preceding hallucinations in patients with schizophrenia using machine learning with structured sparsity
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- de Pierrefeu, Amicie (författare)
- NeuroSpin, CEA, Paris-Saclay, Gif-sur-Yvette, France
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- Fovet, Thomas (författare)
- Univ. Lille, CNRS UMR 9193, Laboratoire de Sciences Cognitives et Sciences Affectives (SCALab), PsyCHIC team, Lille F- 59000, France; CHU Lille, Pôle de Psychiatrie, Unité CURE, Lille F-59000, France
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- Hadj-Selem, Fouad (författare)
- Energy Transition Institute: VeDeCoM, France
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- Löfstedt, Tommy (författare)
- Umeå universitet,Radiofysik
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- Ciuciu, Philippe (författare)
- NeuroSpin, CEA, Paris-Saclay, Gif-sur-Yvette, France; INRIA, CEA, Parietal team, Univ. Paris-Saclay, France
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- Lefebvre, Stephanie (författare)
- Univ. Lille, CNRS UMR 9193, Laboratoire de Sciences Cognitives et Sciences Affectives (SCALab), PsyCHIC team, Lille F-59000, France; CHU Lille, Pôle de Psychiatrie, Unité CURE, Lille F-59000, France
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- Thomas, Pierre (författare)
- Univ. Lille, CNRS UMR 9193, Laboratoire de Sciences Cognitives et Sciences Affectives (SCALab), PsyCHIC team, Lille F-59000, France; CHU Lille, Pôle de Psychiatrie, Unité CURE, Lille F-59000, France
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- Lopes, Renaud (författare)
- Imaging Dpt., Neuroradiology unit, CHU Lille, Lille F-59000, France; U1171 - Degenerative and Vascular Cognitive Disorders, Univ. Lille, INSERM, CHU Lille, Lille F-59000, France
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- Jardri, Renaud (författare)
- Univ. Lille, CNRS UMR 9193, Laboratoire de Sciences Cognitives et Sciences Affectives (SCALab), PsyCHIC team, Lille F-59000, France; CHU Lille, Pôle de Psychiatrie, Unité CURE, Lille F-59000, France
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- Duchesnay, Edouard (författare)
- NeuroSpin, CEA, Paris-Saclay, Gif-sur-Yvette, France
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NeuroSpin, CEA, Paris-Saclay, Gif-sur-Yvette, France Univ Lille, CNRS UMR 9193, Laboratoire de Sciences Cognitives et Sciences Affectives (SCALab), PsyCHIC team, Lille F- 59000, France; CHU Lille, Pôle de Psychiatrie, Unité CURE, Lille F-59000, France (creator_code:org_t)
- 2018-01-16
- 2018
- Engelska.
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Ingår i: Human Brain Mapping. - : Wiley. - 1065-9471 .- 1097-0193. ; 39:4, s. 1777-1788
- Relaterad länk:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Despite significant progress in the field, the detection of fMRI signal changes during hallucinatory events remains difficult and time-consuming. This article first proposes a machine-learning algorithm to automatically identify resting-state fMRI periods that precede hallucinations versus periods that do not. When applied to whole-brain fMRI data, state-of-the-art classification methods, such as support vector machines (SVM), yield dense solutions that are difficult to interpret. We proposed to extend the existing sparse classification methods by taking the spatial structure of brain images into account with structured sparsity using the total variation penalty. Based on this approach, we obtained reliable classifying performances associated with interpretable predictive patterns, composed of two clearly identifiable clusters in speech-related brain regions. The variation in transition-to-hallucination functional patterns not only from one patient to another but also from one occurrence to the next (e.g., also depending on the sensory modalities involved) appeared to be the major difficulty when developing effective classifiers. Consequently, second, this article aimed to characterize the variability within the prehallucination patterns using an extension of principal component analysis with spatial constraints. The principal components (PCs) and the associated basis patterns shed light on the intrinsic structures of the variability present in the dataset. Such results are promising in the scope of innovative fMRI-guided therapy for drug-resistant hallucinations, such as fMRI-based neurofeedback.
Ämnesord
- NATURVETENSKAP -- Data- och informationsvetenskap (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences (hsv//eng)
Nyckelord
- hallucinations
- machine learning
- real-time fMRI
- resting-state networks
- schizophrenia
- Computerized Image Analysis
- datoriserad bildanalys
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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de Pierrefeu, Am ...
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Fovet, Thomas
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Hadj-Selem, Foua ...
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Löfstedt, Tommy
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Ciuciu, Philippe
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Lefebvre, Stepha ...
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Thomas, Pierre
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Lopes, Renaud
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Jardri, Renaud
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Duchesnay, Edoua ...
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