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Sökning: WFRF:(Francis Lucy) > Khleborodova Asya > Microbiome connecti...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005750naa a2200757 4500
001oai:lup.lub.lu.se:5409314a-6333-4b46-bd89-04c4958c9e95
003SwePub
008210215s2021 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/5409314a-6333-4b46-bd89-04c4958c9e952 URI
0247 a https://doi.org/10.1038/s41591-020-01183-82 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Asnicar, Francescou University of Trento4 aut
2451 0a Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals
264 c 2021-01-11
264 1b Springer Science and Business Media LLC,c 2021
520 a The gut microbiome is shaped by diet and influences host metabolism; however, these links are complex and can be unique to each individual. We performed deep metagenomic sequencing of 1,203 gut microbiomes from 1,098 individuals enrolled in the Personalised Responses to Dietary Composition Trial (PREDICT 1) study, whose detailed long-term diet information, as well as hundreds of fasting and same-meal postprandial cardiometabolic blood marker measurements were available. We found many significant associations between microbes and specific nutrients, foods, food groups and general dietary indices, which were driven especially by the presence and diversity of healthy and plant-based foods. Microbial biomarkers of obesity were reproducible across external publicly available cohorts and in agreement with circulating blood metabolites that are indicators of cardiovascular disease risk. While some microbes, such as Prevotella copri and Blastocystis spp., were indicators of favorable postprandial glucose metabolism, overall microbiome composition was predictive for a large panel of cardiometabolic blood markers including fasting and postprandial glycemic, lipemic and inflammatory indices. The panel of intestinal species associated with healthy dietary habits overlapped with those associated with favorable cardiometabolic and postprandial markers, indicating that our large-scale resource can potentially stratify the gut microbiome into generalizable health levels in individuals without clinically manifest disease.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
7001 a Berry, Sarah E.u King's College London4 aut
7001 a Valdes, Ana M.u University of Nottingham,Nottingham Biomedical Research Centre (BRC)4 aut
7001 a Nguyen, Long H.u Massachusetts General Hospital,Harvard University4 aut
7001 a Piccinno, Gianmarcou University of Trento4 aut
7001 a Drew, David A.u Massachusetts General Hospital,Harvard University4 aut
7001 a Leeming, Emilyu King's College London4 aut
7001 a Gibson, Rachelu King's College London4 aut
7001 a Le Roy, Carolineu King's College London4 aut
7001 a Khatib, Haya Alu Zoe Global Limited4 aut
7001 a Francis, Lucyu Zoe Global Limited4 aut
7001 a Mazidi, Mohsenu King's College London4 aut
7001 a Mompeo, Olatzu King's College London4 aut
7001 a Valles-Colomer, Mireiau University of Trento4 aut
7001 a Tett, Adrianu University of Trento4 aut
7001 a Beghini, Francescou University of Trento4 aut
7001 a Dubois, Léonardu University of Trento4 aut
7001 a Bazzani, Davideu University of Trento4 aut
7001 a Thomas, Andrew Maltezu University of Trento4 aut
7001 a Mirzayi, Chloeu City University of New York4 aut
7001 a Khleborodova, Asyau City University of New York4 aut
7001 a Oh, Sehyunu City University of New York4 aut
7001 a Hine, Rachelu Zoe Global Limited4 aut
7001 a Bonnett, Christopheru Zoe Global Limited4 aut
7001 a Capdevila, Joanu Zoe Global Limited4 aut
7001 a Danzanvilliers, Sergeu Zoe Global Limited4 aut
7001 a Giordano, Francescau Zoe Global Limited4 aut
7001 a Geistlinger, Ludwigu City University of New York4 aut
7001 a Waldron, Leviu City University of New York4 aut
7001 a Davies, Richardu Zoe Global Limited4 aut
7001 a Hadjigeorgiou, Georgeu Zoe Global Limited4 aut
7001 a Wolf, Jonathanu Zoe Global Limited4 aut
7001 a Ordovás, José M.u Tufts University,Autonomous University of Madrid4 aut
7001 a Gardner, Christopheru Stanford University4 aut
7001 a Franks, Paul W.u Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Harvard University4 aut0 (Swepub:lu)med-plf
7001 a Chan, Andrew T.u Massachusetts General Hospital,Harvard University,Broad Institute4 aut
7001 a Huttenhower, Curtisu Harvard University,Broad Institute4 aut
7001 a Spector, Tim D.u King's College London4 aut
7001 a Segata, Nicolau University of Trento,European Institute of Oncology4 aut
7102 a University of Trentob King's College London4 org
7730 t Nature Medicined : Springer Science and Business Media LLCg 27:2, s. 321-332q 27:2<321-332x 1078-8956x 1546-170X
8564 u http://dx.doi.org/10.1038/s41591-020-01183-8y FULLTEXT
8564 u https://nottingham-repository.worktribe.com/preview/5273747/Zoe_Microbiome_Paper%20%281%29%20%281%29.pdf
8564 8u https://lup.lub.lu.se/record/5409314a-6333-4b46-bd89-04c4958c9e95
8564 8u https://doi.org/10.1038/s41591-020-01183-8

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