Sökning: WFRF:(Garlick Peter J.)
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Glucose flux is nor...
Glucose flux is normalized by compensatory hyperinsulinaemia in growth hormone-induced insulin resistance in healthy subjects, while skeletal muscle protein synthesis remains unchanged.
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- Nygren, Jonas (författare)
- Centre for Gastrointestinal Disease, Ersta Hospital, Karolinska Institute, Stockholm
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- Thorell, Anders (författare)
- Centre for Gastrointestinal Disease, Ersta Hospital, Karolinska Institute, Stockholm
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- Brismar, Kerstin (författare)
- Department of Endocrinology, Karolinska Hospital, Karolinska Institute, Stocholm
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- Essén, Pia (författare)
- Department of Anaesthesia, Huddinge University Hospital, Karolinska Institute, Stockholm
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- Wernerman, Jan (författare)
- Department of Anaesthesia, Huddinge University Hospital, Karolinska Institute, Stockholm
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- McNurlan, Margaret A (författare)
- Department of Anaesthesia, Huddinge University Hospital, Karolinska Institute, Stockholm
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- Garlick, Peter J (författare)
- Centre for Gastrointestinal Disease, Ersta Hospital, Karolinska Institute, Stockholm
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- Ljungqvist, Olle, 1954- (författare)
- Centre for Gastrointestinal Disease, Ersta Hospital, Karolinska Institute, Stockholm
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(creator_code:org_t)
- London, United Kingdom : Portland Press, 2002
- 2002
- Engelska.
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Ingår i: Clinical Science. - London, United Kingdom : Portland Press. - 0143-5221 .- 1470-8736. ; 102:4, s. 457-64
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The aim of this present investigation was to study the relationship between the reduction in insulin sensitivity accompanying 5 days of treatment with growth hormone (GH; 0.05 mg.24 h(-1).kg(-1)) and intracellular substrate oxidation rates in six healthy subjects, while maintaining glucose flux by a constant glucose infusion and adjusting insulin infusion rates to achieve normoglycaemia (feedback clamp). Protein synthesis rates in skeletal muscle (flooding dose of L-[(2)H(5)]phenylalanine) were determined under these conditions. We also compared changes in insulin sensitivity after GH treatment with simultaneous changes in energy requirements, protein synthesis rates, nitrogen balance, 3-methylhistidine excretion in urine, body composition and the hormonal milieu. After GH treatment, 70% more insulin was required to maintain normoglycaemia (P<0.01). The ratio between glucose infusion rate and serum insulin levels decreased by 34% at the two levels of glucose infusion tested (P<0.05). Basal levels of C-peptide, insulin-like growth factor (IGF)-I and IGF-binding protein-3 increased almost 2-fold, while levels of glucose, insulin, glucagon, GH and IGF-binding protein-1 remained unchanged. Non-esterified fatty acid levels decreased (P<0.05). In addition, 24 h urinary nitrogen excretion decreased by 26% (P<0.01) after GH treatment, while skeletal muscle protein synthesis and 3-methylhistidine excretion in urine remained unchanged. Energy expenditure increased by 5% (P<0.05) after treatment, whereas fat and carbohydrate oxidation were unaltered. In conclusion, when glucose flux was normalized by compensatory hyperinsulinaemia under conditions of GH-induced insulin resistance, intracellular rates of oxidation of glucose and fat remained unchanged. The nitrogen retention accompanying GH treatment seems to be due largely to improved nitrogen balance in non-muscle tissue.
Nyckelord
- Glucose clamp technique
- glucose metabolism
- growth hormone
- insulin resistance
- protein metabolism
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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