WFRF:(Gashi G.)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05183naa a2201009 4500 | |
| 001 | oai:gup.ub.gu.se/328122 | |
| 003 | SwePub | |
| 008 | 240528s2023 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3281222 URI |
| 024 | 7 | a https://doi.org/10.1038/s41586-023-05863-62 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Gruhl, T.4 aut |
| 245 | 1 0 | a Ultrafast structural changes direct the first molecular events of vision |
| 264 | c 2023-03-22 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2023 |
| 520 | a Vision is initiated by the rhodopsin family of light-sensitive G protein-coupled receptors (GPCRs)(1). A photon is absorbed by the 11-cis retinal chromophore of rhodopsin, which isomerizes within 200 femtoseconds to the all-trans conformation(2), thereby initiating the cellular signal transduction processes that ultimately lead to vision. However, the intramolecular mechanism by which the photoactivated retinal induces the activation events inside rhodopsin remains experimentally unclear. Here we use ultrafast time-resolved crystallography at room temperature(3) to determine how an isomerized twisted all-trans retinal stores the photon energy that is required to initiate the protein conformational changes associated with the formation of the G protein-binding signalling state. The distorted retinal at a 1-ps time delay after photoactivation has pulled away from half of its numerous interactions with its binding pocket, and the excess of the photon energy is released through an anisotropic protein breathing motion in the direction of the extracellular space. Notably, the very early structural motions in the protein side chains of rhodopsin appear in regions that are involved in later stages of the conserved class A GPCR activation mechanism. Our study sheds light on the earliest stages of vision in vertebrates and points to fundamental aspects of the molecular mechanisms of agonist-mediated GPCR activation. | |
| 650 | 7 | a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng |
| 653 | a energy-storage | |
| 653 | a excited-state | |
| 653 | a counterion displacement | |
| 653 | a retinal | |
| 653 | a chromophore | |
| 653 | a basis-sets | |
| 653 | a rhodopsin | |
| 653 | a crystallography | |
| 653 | a dynamics | |
| 653 | a isomerization | |
| 653 | a software | |
| 653 | a Science & Technology - Other Topics | |
| 700 | 1 | a Weinert, T.4 aut |
| 700 | 1 | a Rodrigues, M. J.4 aut |
| 700 | 1 | a Milne, C. J.4 aut |
| 700 | 1 | a Ortolani, Giorgia,d 1985u Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology4 aut0 (Swepub:gu)xortgi |
| 700 | 1 | a Nass, K.4 aut |
| 700 | 1 | a Nango, E.4 aut |
| 700 | 1 | a Sen, S.4 aut |
| 700 | 1 | a Johnson, P. J. M.4 aut |
| 700 | 1 | a Cirelli, C.4 aut |
| 700 | 1 | a Furrer, A.4 aut |
| 700 | 1 | a Mous, S.4 aut |
| 700 | 1 | a Skopintsev, P.4 aut |
| 700 | 1 | a James, D.4 aut |
| 700 | 1 | a Dworkowski, F.4 aut |
| 700 | 1 | a Båth, Petra,d 1988u Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology4 aut0 (Swepub:gu)xbatpe |
| 700 | 1 | a Kekilli, D.4 aut |
| 700 | 1 | a Ozerov, D.4 aut |
| 700 | 1 | a Tanaka, R.4 aut |
| 700 | 1 | a Glover, H.4 aut |
| 700 | 1 | a Bacellar, C.4 aut |
| 700 | 1 | a Brunle, S.4 aut |
| 700 | 1 | a Casadei, C. M.4 aut |
| 700 | 1 | a Diethelm, A. D.4 aut |
| 700 | 1 | a Gashi, D.4 aut |
| 700 | 1 | a Gotthard, G.4 aut |
| 700 | 1 | a Guixa-Gonzalez, R.4 aut |
| 700 | 1 | a Joti, Y.4 aut |
| 700 | 1 | a Kabanova, V.4 aut |
| 700 | 1 | a Knopp, G.4 aut |
| 700 | 1 | a Lesca, E.4 aut |
| 700 | 1 | a Ma, P. K. Y.4 aut |
| 700 | 1 | a Martiel, I.4 aut |
| 700 | 1 | a Mnhle, J.4 aut |
| 700 | 1 | a Owada, S.4 aut |
| 700 | 1 | a Pamula, F.4 aut |
| 700 | 1 | a Sarabi, Daniel,d 1987u Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology4 aut0 (Swepub:gu)xsarad |
| 700 | 1 | a Tejero, O.4 aut |
| 700 | 1 | a Tsai, C. J.4 aut |
| 700 | 1 | a Varma, N.4 aut |
| 700 | 1 | a Wach, A.4 aut |
| 700 | 1 | a Boutet, S.4 aut |
| 700 | 1 | a Tono, K.4 aut |
| 700 | 1 | a Nogly, P.4 aut |
| 700 | 1 | a Deupi, X.4 aut |
| 700 | 1 | a Iwata, S.4 aut |
| 700 | 1 | a Neutze, Richard,d 1969u Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology4 aut0 (Swepub:gu)xneuri |
| 700 | 1 | a Standfuss, J.4 aut |
| 700 | 1 | a Schertler, G.4 aut |
| 700 | 1 | a Panneels, V.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för kemi och molekylärbiologi4 org |
| 773 | 0 | t Natured : Springer Science and Business Media LLCg 615, s. 939-944q 615<939-944x 0028-0836x 1476-4687 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/328122 |
| 856 | 4 8 | u https://doi.org/10.1038/s41586-023-05863-6 |
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- Gruhl, T.
- Weinert, T.
- Rodrigues, M. J.
- Milne, C. J.
- Ortolani, Giorgi ...
- Nass, K.
- visa fler...
- Nango, E.
- Sen, S.
- Johnson, P. J. M ...
- Cirelli, C.
- Furrer, A.
- Mous, S.
- Skopintsev, P.
- James, D.
- Dworkowski, F.
- Båth, Petra, 198 ...
- Kekilli, D.
- Ozerov, D.
- Tanaka, R.
- Glover, H.
- Bacellar, C.
- Brunle, S.
- Casadei, C. M.
- Diethelm, A. D.
- Gashi, D.
- Gotthard, G.
- Guixa-Gonzalez, ...
- Joti, Y.
- Kabanova, V.
- Knopp, G.
- Lesca, E.
- Ma, P. K. Y.
- Martiel, I.
- Mnhle, J.
- Owada, S.
- Pamula, F.
- Sarabi, Daniel, ...
- Tejero, O.
- Tsai, C. J.
- Varma, N.
- Wach, A.
- Boutet, S.
- Tono, K.
- Nogly, P.
- Deupi, X.
- Iwata, S.
- Neutze, Richard, ...
- Standfuss, J.
- Schertler, G.
- Panneels, V.
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