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Sökning: WFRF:(Gegg Matthew E.) > (2017) > DJ-1 is a redox sen...

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FältnamnIndikatorerMetadata
00004611naa a2200553 4500
001oai:DiVA.org:umu-140877
003SwePub
008171120s2017 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1408772 URI
0247 a https://doi.org/10.1093/hmg/ddx2942 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Piston, Dominik4 aut
2451 0a DJ-1 is a redox sensitive adapter protein for high molecular weight complexes involved in regulation of catecholamine homeostasis
264 c 2017-07-25
264 1b Oxford University Press,c 2017
338 a electronic2 rdacarrier
500 a Correction: Dominik Piston, Lydia Alvarez-Erviti, Vikas Bansal, Daniela Gargano, Zhi Yao, Gyorgy Szabadkai, Mark Odell, M Rhyan Puno, Benny Björkblom, Jodi Maple-Grødem, Peter Breuer, Oliver Kaut, Jan Petter Larsen, Stefan Bonn, Simon Geir Møller, Ullrich Wüllner, Anthony H V Schapira, Matthew E Gegg. DJ-1 is a redox sensitive adapter protein for high molecular weight complexes involved in regulation of catecholamine homeostasis. Human Molecular Genetics. Volume 27, Issue 3, 1 February 2018, Pages 576. DOI: 10.1093/hmg/ddx425
520 a DJ-1 is an oxidation sensitive protein encoded by the PARK7 gene. Mutations in PARK7 are a rare cause of familial recessive Parkinson's disease (PD), but growing evidence suggests involvement of DJ-1 in idiopathic PD. The key clinical features of PD, rigidity and bradykinesia, result from neurotransmitter imbalance, particularly the catecholamines dopamine (DA) and noradrenaline. We report in human brain and human SH-SY5Y neuroblastoma cell lines that DJ-1 predominantly forms high molecular weight (HMW) complexes that included RNA metabolism proteins hnRNPA1 and PABP1 and the glycolysis enzyme GAPDH. In cell culture models the oxidation status of DJ-1 determined the specific complex composition. RNA sequencing indicated that oxidative changes to DJ-1 were concomitant with changes in mRNA transcripts mainly involved in catecholamine metabolism. Importantly, loss of DJ-1 function upon knock down (KD) or expression of the PD associated form L166P resulted in the absence of HMW DJ-1 complexes. In the KD model, the absence of DJ-1 complexes was accompanied by impairment in catecholamine homeostasis, with significant increases in intracellular DA and noraderenaline levels. These changes in catecholamines could be rescued by re-expression of DJ-1. This catecholamine imbalance may contribute to the particular vulnerability of dopaminergic and noradrenergic neurons to neurodegeneration in PARK7-related PD. Notably, oxidised DJ-1 was significantly decreased in idiopathic PD brain, suggesting altered complex function may also play a role in the more common sporadic form of the disease.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng
7001 a Alvarez-Erviti, Lydia4 aut
7001 a Bansal, Vikas4 aut
7001 a Gargano, Daniela4 aut
7001 a Yao, Zhi4 aut
7001 a Szabadkai, Gyorgy4 aut
7001 a Odell, Mark4 aut
7001 a Puno, M. Rhyan4 aut
7001 a Björkblom, Bennyu Umeå universitet,Kemiska institutionen4 aut0 (Swepub:umu)bebj0009
7001 a Maple-Grodem, Jodi4 aut
7001 a Breuer, Peter4 aut
7001 a Kaut, Oliver4 aut
7001 a Larsen, Jan Petter4 aut
7001 a Bonn, Stefan4 aut
7001 a Moller, Simon Geir4 aut
7001 a Wuellner, Ullrich4 aut
7001 a Schapira, Anthony H. V.4 aut
7001 a Gegg, Matthew E.4 aut
7102 a Umeå universitetb Kemiska institutionen4 org
7730 t Human Molecular Geneticsd : Oxford University Pressg 26:20, s. 4028-4041q 26:20<4028-4041x 0964-6906x 1460-2083
8564 u https://umu.diva-portal.org/smash/get/diva2:1158427/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://academic.oup.com/hmg/article-pdf/26/20/4028/24339317/ddx294.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-140877
8564 8u https://doi.org/10.1093/hmg/ddx294

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