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FältnamnIndikatorerMetadata
00008454naa a2201081 4500
001oai:DiVA.org:oru-3665
003SwePub
008081217s2008 | |||||||||||000 ||eng|
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0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-36652 URI
0247 a https://doi.org/10.1093/jnci/djn2552 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-880732 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1175453802 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-456112 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-361132 URI
040 a (SwePub)orud (SwePub)uud (SwePub)kid (SwePub)liud (SwePub)su
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Bill-Axelson, Annau Uppsala universitet,Urologkirurgi,Department of Urology, University Hospital, Uppsala, Sweden4 aut0 (Swepub:uu)anbil030
2451 0a Radical prostatectomy versus watchful waiting in localized prostate cancer :b the Scandinavian prostate cancer group-4 randomized trial
264 c 2008-08-11
264 1b Oxford University Press,c 2008
338 a print2 rdacarrier
520 a BACKGROUND: The benefit of radical prostatectomy in patients with early prostate cancer has been assessed in only one randomized trial. In 2005, we reported that radical prostatectomy improved prostate cancer survival compared with watchful waiting after a median of 8.2 years of follow-up. We now report results after 3 more years of follow-up.METHODS: From October 1, 1989, through February 28, 1999, 695 men with clinically localized prostate cancer were randomly assigned to radical prostatectomy (n = 347) or watchful waiting (n = 348). Follow-up was complete through December 31, 2006, with histopathologic review and blinded evaluation of causes of death. Relative risks (RRs) were estimated using the Cox proportional hazards model. Statistical tests were two-sided.RESULTS: During a median of 10.8 years of follow-up (range = 3 weeks to 17.2 years), 137 men in the surgery group and 156 in the watchful waiting group died (P = .09). For 47 of the 347 men (13.5%) who were randomly assigned to surgery and 68 of the 348 men (19.5%) who were not, death was due to prostate cancer. The difference in cumulative incidence of death due to prostate cancer remained stable after about 10 years of follow-up. At 12 years, 12.5% of the surgery group and 17.9% of the watchful waiting group had died of prostate cancer (difference = 5.4%, 95% confidence interval [CI] = 0.2 to 11.1%), for a relative risk of 0.65 (95% CI = 0.45 to 0.94; P = .03). The difference in cumulative incidence of distant metastases did not increase beyond 10 years of follow-up. At 12 years, 19.3% of men in the surgery group and 26% of men in the watchful waiting group had been diagnosed with distant metastases (difference = 6.7%, 95% CI = 0.2 to 13.2%), for a relative risk of 0.65 (95% CI = 0.47 to 0.88; P = .006). Among men who underwent radical prostatectomy, those with extracapsular tumor growth had 14 times the risk of prostate cancer death as those without it (RR = 14.2, 95% CI = 3.3 to 61.8; P < .001).CONCLUSION: Radical prostatectomy reduces prostate cancer mortality and risk of metastases with little or no further increase in benefit 10 or more years after surgery. 
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Aged
653 a Follow-Up Studies
653 a Humans
653 a Male
653 a Middle Aged
653 a Neoplasm Staging
653 a Odds Ratio
653 a Proportional Hazards Models
653 a Prostate-Specific Antigen/blood
653 a Prostatectomy/methods
653 a Prostatic Neoplasms/immunology/*mortality/pathology/*surgery
653 a Research Design
653 a Risk Assessment
653 a Scandinavia/epidemiology
653 a Time Factors
653 a MEDICINE
653 a MEDICIN
653 a Surgery
653 a Kirurgi
653 a Oncology
653 a Onkologi
653 a Onkologi
653 a Oncology
7001 a Holmberg, Larsu Uppsala universitet,Endokrinkirurgi,Regional Oncologic Center, University Hospital, Uppsala, Sweden, King's College London, School of Medicine, Division of Cancer Studies, London, United Kingdom, Medical School, Division of Cancer Studies, Guy's Hospital, London SE1 9RT, United Kingdom4 aut0 (Swepub:uu)larsholmb
7001 a Filén, Freju Uppsala universitet,Urologkirurgi,Filén, F., Department of Urology, University Hospital, Uppsala, Sweden4 aut0 (Swepub:uu)frefi234
7001 a Ruutu, Mirjau Department of Urology, Helsinki University Central Hospital, Helsinki, Finland4 aut
7001 a Garmo, Hansu Regional Oncologic Center, University Hospital, Uppsala, Sweden4 aut
7001 a Busch, Christeru Uppsala universitet,Institutionen för genetik och patologi,Department of Pathology, University Hospital, Uppsala, Sweden4 aut
7001 a Nordling, Stigu Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland4 aut
7001 a Häggman, Michaelu Uppsala universitet,Urologkirurgi,Häggman, M., Department of Urology, University Hospital, Uppsala, Sweden4 aut0 (Swepub:uu)michhagg
7001 a Andersson, Swen-Olofu Örebro universitet,Hälsoakademin,Department of Urology, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)sfan
7001 a Bratell, Stefanu Department of Urology, Borås Hospital, Borås, Sweden4 aut
7001 a Spångberg, Andersu Östergötlands Läns Landsting,Linköpings universitet,Urologi,Hälsouniversitetet,Urologiska kliniken i Östergötland4 aut0 (Swepub:liu)andsp66
7001 a Palmgren, Juniu Stockholms universitet,Karolinska Institutet,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden,Matematiska institutionen,Palmgren4 aut
7001 a Adami, Hans-Olovu Karolinska Institutet,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden, Department of Epidemiology, Harvard School of Public Health, Boston, MA, United States4 aut
7001 a Johansson, Jan-Eriku Örebro universitet,Hälsoakademin,Department of Urology, Örebro University Hospital, Örebro, Sweden, Center for Assessment of Medical Technology, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)jkjn
7001 a Lindeborg, T.4 aut
7001 a Einarsson, G.4 aut
7001 a Ekman, P.4 aut
7001 a Wijkström, H.4 aut
7001 a Karlberg, L.4 aut
7001 a Hagberg, G.4 aut
7001 a de la Torre, Manuelu Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)manutorr
7001 a Hamberg, Hansu Uppsala universitet,Institutionen för genetik och patologi4 aut
7001 a Lindgren, Andersu Uppsala universitet,Institutionen för genetik och patologi4 aut
7001 a Mavadati, E.4 aut
7001 a Gobén, B.4 aut
7001 a Pettersson, I.4 aut
7001 a Varenhorst, E.4 aut
7001 a Norlén, B.J.4 aut
7102 a Uppsala universitetb Urologkirurgi4 org
7730 t Journal of the National Cancer Instituted : Oxford University Pressg 100:16, s. 1144-1154q 100:16<1144-1154x 0027-8874x 1460-2105
8564 u https://doi.org/10.1093/jnci/djn255y Fulltext
8564 u https://academic.oup.com/jnci/article-pdf/100/16/1144/7682618/djn255.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-3665
8564 8u https://doi.org/10.1093/jnci/djn255
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-88073
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:117545380
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-45611
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-36113

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