Comparison of vilanterol, a novel long-acting beta2 agonist, with placebo and a salmeterol reference arm in asthma uncontrolled by inhaled corticosteroids.

Lötvall, Jan, 1956 (author): Gothenburg University,Göteborgs universitet,Krefting Research Centre

Bateman, Eric D (author)

Busse, William W (author)

O'Byrne, Paul M (author)

Woodcock, Ashley (author)

Toler, William T (author)

Jacques, Loretta (author)

Goldfrad, Caroline (author)

Bleecker, Eugene R (author)

(creator_code:org_t)

2014-06-13
2014
English.
In: Journal of negative results in biomedicine. - : Springer Science and Business Media LLC. - 1477-5751. ; 13:1

Related links:: https://jnrbm.biomed...; show more...; https://gup.ub.gu.se...; https://doi.org/10.1...; show less...

Abstract Subject headings

Current maintenance therapies for asthma require twice-daily dosing. Vilanterol (VI) is a novel long-acting beta2 agonist, under development in combination with fluticasone furoate, a new inhaled corticosteroid (ICS). Findings from a previous 4-week study suggested that VI has inherent 24-hour activity and is therefore suitable for once-daily dosing. The study described here was a double-blind, double-dummy, randomised, placebo-controlled trial, the aim of which was to assess the efficacy of once-daily VI compared with placebo in patients with persistent asthma. The primary endpoint was change from baseline in 24-hour weighted mean forced expiratory volume in 1second after 12weeks of treatment vs. placebo. An active control arm received salmeterol (SAL) twice daily. All patients were maintained on a stable background dose of ICS.

By the author/editor: Lötvall, Jan, 19 ...; Bateman, Eric D; Busse, William W; O'Byrne, Paul M; Woodcock, Ashley; Toler, William T; show more...; Jacques, Loretta; Goldfrad, Caroli ...; Bleecker, Eugene ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Respiratory Medi ...

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