Sökning: WFRF:(Gong Sungsam) > Fetal inheritance o...
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000 | 05104naa a2200505 4500 | |
001 | oai:DiVA.org:uu-411288 | |
003 | SwePub | |
008 | 200529s2020 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4112882 URI |
024 | 7 | a https://doi.org/10.1038/s41564-020-0711-32 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Gaccioli, Francescau Univ Cambridge, Dept Obstet & Gynaecol, Cambridge, England; Univ Cambridge, Ctr Trophoblast Res, Cambridge, England4 aut |
245 | 1 0 | a Fetal inheritance of chromosomally integrated human herpesvirus 6 predisposes the mother to pre-eclampsia |
264 | c 2020-05-04 | |
264 | 1 | b Springer Nature,c 2020 |
338 | a print2 rdacarrier | |
500 | a Susanne Lager is shared first author with Francesca Gaccioli and Marcus de Goffau. | |
520 | a Pre-eclampsia (typically characterized by new-onset hypertension and proteinuria in the second half of pregnancy) represents a major determinant of the global burden of disease1,2. Its pathophysiology involves placental dysfunction, but the mechanism is unclear. Viral infection can cause organ dysfunction, but its role in placentally related disorders of human pregnancy is unknown3. We addressed this using RNA sequencing metagenomics4-6 of placental samples from normal and complicated pregnancies. Here, we show that human herpesvirus 6 (HHV-6, A or B) RNA was detected in 6.1% of cases of pre-eclampsia and 2.2% of other pregnancies. Fetal genotyping demonstrated that 70% of samples with HHV-6 RNA in the placenta exhibited inherited, chromosomally integrated HHV-6 (iciHHV-6). We genotyped 467 pre-eclampsia cases and 3,854 controls and found an excess of iciHHV-6 in the cases (odds ratio of 2.8, 95% confidence intervals of 1.4-5.6, P = 0.008). We validated this finding by comparing iciHHV-6 in a further 740 cases with controls from large-scale population studies (odds ratio of 2.5, 95% confidence intervals of 1.4-4.4, P = 0.0013). We conclude that iciHHV-6 results in the transcription of viral RNA in the human placenta and predisposes the mother to pre-eclampsia. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng |
700 | 1 | a Lager, Susanneu Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning,Univ Cambridge, Dept Obstet & Gynaecol, Cambridge, England; Univ Cambridge, Ctr Trophoblast Res, Cambridge, England4 aut0 (Swepub:uu)susla462 |
700 | 1 | a de Goffau, Marcus Cu Univ Cambridge, Dept Vet Med, Cambridge, England4 aut |
700 | 1 | a Sovio, Ullau Univ Cambridge, Dept Obstet & Gynaecol, Cambridge, England; Univ Cambridge, Ctr Trophoblast Res, Cambridge, England4 aut |
700 | 1 | a Dopierala, Justynau Univ Cambridge, Dept Obstet & Gynaecol, Cambridge, England; Univ Cambridge, Ctr Trophoblast Res, Cambridge, England; GlaxoSmithKline Ltd, Funct Genom, Stevenage, Herts, England4 aut |
700 | 1 | a Gong, Sungsamu Univ Cambridge, Dept Obstet & Gynaecol, Cambridge, England4 aut |
700 | 1 | a Cook, Emmau Univ Cambridge, Dept Obstet & Gynaecol, Cambridge, England4 aut |
700 | 1 | a Sharkey, Andrewu Univ Cambridge, Ctr Trophoblast Res, Cambridge, England; Univ Cambridge, Dept Pathol, Cambridge, England4 aut |
700 | 1 | a Moffett, Ashleyu Univ Cambridge, Ctr Trophoblast Res, Cambridge, England; Univ Cambridge, Dept Pathol, Cambridge, England4 aut |
700 | 1 | a Lee, Wai Kwongu Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland4 aut |
700 | 1 | a Delles, Christianu Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland4 aut |
700 | 1 | a Venturini, Cristinau UCL, Div Infect & Immun, London, England4 aut |
700 | 1 | a Breuer, Judithu UCL, Div Infect & Immun, London, England; Great Ormond St Hosp Children NHS Fdn Trust, London, England4 aut |
700 | 1 | a Parkhill, Julianu Univ Cambridge, Dept Vet Med, Cambridge, England4 aut |
700 | 1 | a Peacock, Sharon Ju Univ Cambridge, Dept Med, Cambridge, England; London Sch Hyg & Trop Med, London, England4 aut |
700 | 1 | a Charnock-Jones, D. Stephenu Univ Cambridge, Dept Obstet & Gynaecol, Cambridge, England; Univ Cambridge, Ctr Trophoblast Res, Cambridge, England4 aut |
700 | 1 | a Smith, Gordon C Su Univ Cambridge, Dept Obstet & Gynaecol, Cambridge, England; Univ Cambridge, Ctr Trophoblast Res, Cambridge, England4 aut |
710 | 2 | a Univ Cambridge, Dept Obstet & Gynaecol, Cambridge, England; Univ Cambridge, Ctr Trophoblast Res, Cambridge, Englandb Obstetrisk och reproduktiv hälsoforskning4 org |
773 | 0 | t Nature Microbiologyd : Springer Natureg 5:7, s. 901-908q 5:7<901-908x 2058-5276 |
856 | 4 | u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610361 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-411288 |
856 | 4 8 | u https://doi.org/10.1038/s41564-020-0711-3 |
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