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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005104naa a2200505 4500
001oai:DiVA.org:uu-411288
003SwePub
008200529s2020 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4112882 URI
0247 a https://doi.org/10.1038/s41564-020-0711-32 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Gaccioli, Francescau Univ Cambridge, Dept Obstet & Gynaecol, Cambridge, England; Univ Cambridge, Ctr Trophoblast Res, Cambridge, England4 aut
2451 0a Fetal inheritance of chromosomally integrated human herpesvirus 6 predisposes the mother to pre-eclampsia
264 c 2020-05-04
264 1b Springer Nature,c 2020
338 a print2 rdacarrier
500 a Susanne Lager is shared first author with Francesca Gaccioli and Marcus de Goffau.
520 a Pre-eclampsia (typically characterized by new-onset hypertension and proteinuria in the second half of pregnancy) represents a major determinant of the global burden of disease1,2. Its pathophysiology involves placental dysfunction, but the mechanism is unclear. Viral infection can cause organ dysfunction, but its role in placentally related disorders of human pregnancy is unknown3. We addressed this using RNA sequencing metagenomics4-6 of placental samples from normal and complicated pregnancies. Here, we show that human herpesvirus 6 (HHV-6, A or B) RNA was detected in 6.1% of cases of pre-eclampsia and 2.2% of other pregnancies. Fetal genotyping demonstrated that 70% of samples with HHV-6 RNA in the placenta exhibited inherited, chromosomally integrated HHV-6 (iciHHV-6). We genotyped 467 pre-eclampsia cases and 3,854 controls and found an excess of iciHHV-6 in the cases (odds ratio of 2.8, 95% confidence intervals of 1.4-5.6, P = 0.008). We validated this finding by comparing iciHHV-6 in a further 740 cases with controls from large-scale population studies (odds ratio of 2.5, 95% confidence intervals of 1.4-4.4, P = 0.0013). We conclude that iciHHV-6 results in the transcription of viral RNA in the human placenta and predisposes the mother to pre-eclampsia.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
7001 a Lager, Susanneu Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning,Univ Cambridge, Dept Obstet & Gynaecol, Cambridge, England; Univ Cambridge, Ctr Trophoblast Res, Cambridge, England4 aut0 (Swepub:uu)susla462
7001 a de Goffau, Marcus Cu Univ Cambridge, Dept Vet Med, Cambridge, England4 aut
7001 a Sovio, Ullau Univ Cambridge, Dept Obstet & Gynaecol, Cambridge, England; Univ Cambridge, Ctr Trophoblast Res, Cambridge, England4 aut
7001 a Dopierala, Justynau Univ Cambridge, Dept Obstet & Gynaecol, Cambridge, England; Univ Cambridge, Ctr Trophoblast Res, Cambridge, England; GlaxoSmithKline Ltd, Funct Genom, Stevenage, Herts, England4 aut
7001 a Gong, Sungsamu Univ Cambridge, Dept Obstet & Gynaecol, Cambridge, England4 aut
7001 a Cook, Emmau Univ Cambridge, Dept Obstet & Gynaecol, Cambridge, England4 aut
7001 a Sharkey, Andrewu Univ Cambridge, Ctr Trophoblast Res, Cambridge, England; Univ Cambridge, Dept Pathol, Cambridge, England4 aut
7001 a Moffett, Ashleyu Univ Cambridge, Ctr Trophoblast Res, Cambridge, England; Univ Cambridge, Dept Pathol, Cambridge, England4 aut
7001 a Lee, Wai Kwongu ‎ Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland4 aut
7001 a Delles, Christianu ‎ Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland4 aut
7001 a Venturini, Cristinau UCL, Div Infect & Immun, London, England4 aut
7001 a Breuer, Judithu UCL, Div Infect & Immun, London, England; Great Ormond St Hosp Children NHS Fdn Trust, London, England4 aut
7001 a Parkhill, Julianu Univ Cambridge, Dept Vet Med, Cambridge, England4 aut
7001 a Peacock, Sharon Ju Univ Cambridge, Dept Med, Cambridge, England; London Sch Hyg & Trop Med, London, England4 aut
7001 a Charnock-Jones, D. Stephenu Univ Cambridge, Dept Obstet & Gynaecol, Cambridge, England; Univ Cambridge, Ctr Trophoblast Res, Cambridge, England4 aut
7001 a Smith, Gordon C Su Univ Cambridge, Dept Obstet & Gynaecol, Cambridge, England; Univ Cambridge, Ctr Trophoblast Res, Cambridge, England4 aut
7102 a Univ Cambridge, Dept Obstet & Gynaecol, Cambridge, England; Univ Cambridge, Ctr Trophoblast Res, Cambridge, Englandb Obstetrisk och reproduktiv hälsoforskning4 org
7730 t Nature Microbiologyd : Springer Natureg 5:7, s. 901-908q 5:7<901-908x 2058-5276
8564 u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610361
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-411288
8564 8u https://doi.org/10.1038/s41564-020-0711-3

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