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Metabolic engineering strategies for microbial synthesis of oleochemicals
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- Pfleger, B. F. (author)
- University of Wisconsin Madison
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- Gossing, Michael, 1982 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Nielsen, Jens B, 1962 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
- (creator_code:org_t)
- Elsevier BV, 2015
- 2015
- English.
- In: Metabolic Engineering. - : Elsevier BV. - 1096-7176 .- 1096-7184. ; 29, s. 1-11
- Journal article (other academic/artistic)
Abstract
Subject headings
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- Microbial synthesis of oleochemicals has advanced significantly in the last decade. Microbes have been engineered to convert renewable substrates to a wide range of molecules that are ordinarily made from plant oils. This approach is attractive because it can reduce a motivation for converting tropical rainforest into farmland while simultaneously enabling access to molecules that are currently expensive to produce from oil crops. In the last decade, enzymes responsible for producing oleochemicals in nature have been identified, strategies to circumvent native regulation have been developed, and high yielding strains have been designed, built, and successfully demonstrated. This review will describe the metabolic pathways that lead to the diverse molecular features found in natural oleochemicals, highlight successful metabolic engineering strategies, and comment on areas where future work could further advance the field.
Subject headings
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
Keyword
- Synthetic biology
- Oleochemical
- Fatty acid
- Biodisesel
- Metabolic engineering
Publication and Content Type
- art (subject category)
- vet (subject category)
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