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Search: WFRF:(Grotmol Tom) > (2005-2009) > The RsaI polymorphi...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004981naa a2200445 4500
001oai:lup.lub.lu.se:277f8102-9108-4492-a11d-f3ba0fb9df6c
003SwePub
008160401s2005 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/1423222 URI
0247 a https://doi.org/10.1210/jc.2005-02632 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Aschim, Elin L4 aut
2451 0a The RsaI polymorphism in the ER{beta} gene is associated with male infertility.
264 1b The Endocrine Society,c 2005
520 a Context: Hypospadias, cryptorchidism, testicular cancer, and low semen quality have been proposed as being parts of the testicular dysgenesis syndrome (TDS) hypothetically due to changes in the androgen- estrogen balance in utero. Estrogens and estrogen receptors (ERs) play a role in regulating testicular function. ER beta contains two silent polymorphisms, RsaI (G1082A) and AluI (G1730A). Objective: We investigated the significance of these polymorphisms in the etiology of disorders being part of TDS. Setting: The patients were recruited consecutively through university hospital clinics. Participants: Four groups of Caucasian patients were included: 106 men from infertile couples with a sperm concentration less than 5 x 106 spermatozoa/ ml, 86 testicular cancer patients, 51 boys with hypospadias, and 23 cases with cryptorchidism. Military conscripts (n = 186) with sperm concentration higher than 5 x 10(6) spermatozoa/ ml served as controls. Main Outcome Measures: ER beta polymorphisms RsaI and AluI were determined by allele-specific PCR. In addition, reproductive hormone analyses were performed in controls and infertile men. Results: Compared with the controls, the frequency of the heterozygous RsaI AG-genotype was three times higher in infertile men (13.2 vs. 4.3%; P = 0.01). The heterozygous RsaI AG-genotype was associated with an approximately 20% reduction in LH concentration, compared with the wild-type RsaI GG genotype in both controls and infertile men. Subjects with testicular cancer, hypospadias, or cryptorchidism did not differ from controls regarding the frequency of any of the polymorphisms. Conclusions: Polymorphisms in ER beta may have modulating effects on human spermatogenesis. The phenotype of TDS seems to be, at least partly, determined by the genotype.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
7001 a Giwercman, Aleksanderu Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)kir-agi
7001 a Ståhl, Olofu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine4 aut0 (Swepub:lu)kir-ost
7001 a Eberhard, Jakobu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Institutionen för kliniska vetenskaper, Malmö,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Clinical Sciences, Malmö4 aut0 (Swepub:lu)kir-jeb
7001 a Cwikiel, Magdalenau Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-mcw
7001 a Nordenskjöld, Agneta4 aut
7001 a Haugen, Trine B4 aut
7001 a Grotmol, Tom4 aut
7001 a Giwercman, Yvonne L4 aut
7102 a Reproduktionsmedicin, Malmöb Forskargrupper vid Lunds universitet4 org
7730 t Journal of Clinical Endocrinology and Metabolismd : The Endocrine Societyg 90:Jul 5, s. 5343-5348q 90:Jul 5<5343-5348x 1945-7197x 0021-972X
8564 u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15998774&dopt=Abstractx freey FULLTEXT
8564 u http://dx.doi.org/10.1210/jc.2005-0263x freey FULLTEXT
8564 u https://academic.oup.com/jcem/article-pdf/90/9/5343/10777452/jcem5343.pdf
8564 8u https://lup.lub.lu.se/record/142322
8564 8u https://doi.org/10.1210/jc.2005-0263

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Aschim, Elin L
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