WFRF:(Gutenkunst Ryan N.)
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Characterizing selective pressures on the pathway for de novo biosynthesis of pyrimidines in yeast.
- Hermansen, Russell A (author)
- Mannakee, Brian K (author)
-
- Knecht, Wolfgang (author)
- Lund University,Lunds universitet,Molekylär cellbiologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Molecular Cell Biology,Department of Biology,Faculty of Science
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- Liberles, David A (author)
- Gutenkunst, Ryan N (author)
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- (creator_code:org_t)
- 2015-10-28
- 2015
- English.
- In: BMC Evolutionary Biology. - : Springer Science and Business Media LLC. - 1471-2148. ; 15
- Journal article (peer-reviewed)
Abstract
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- Selection on proteins is typically measured with the assumption that each protein acts independently. However, selection more likely acts at higher levels of biological organization, requiring an integrative view of protein function. Here, we built a kinetic model for de novo pyrimidine biosynthesis in the yeast Saccharomyces cerevisiae to relate pathway function to selective pressures on individual protein-encoding genes.
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
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