Sökning: WFRF:(Hagg E) > Refereegranskat > Medicin och hälsovetenskap > Chirlaque Maria Dolores > Genome-wide Associa...
Fältnamn | Indikatorer | Metadata |
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000 | 08150naa a2201633 4500 | |
001 | oai:DiVA.org:umu-169391 | |
003 | SwePub | |
008 | 200401s2020 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:11710ffd-da84-4326-be0b-382b4af208ad | |
009 | oai:prod.swepub.kib.ki.se:143190360 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1693912 URI |
024 | 7 | a https://doi.org/10.1016/j.ajhg.2020.02.0062 DOI |
024 | 7 | a https://lup.lub.lu.se/record/11710ffd-da84-4326-be0b-382b4af208ad2 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1431903602 URI |
040 | a (SwePub)umud (SwePub)lud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Li, Chenu Glenfield Hospital,University of Cambridge4 aut |
245 | 1 0 | a Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length |
264 | 1 | b CELL PRESS,c 2020 |
338 | a electronic2 rdacarrier | |
520 | a Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed association results across large-scale European-descent studies including up to 78,592 individuals. We identify 49 genomic regions at a false dicovery rate (FDR) < 0.05 threshold and prioritize genes at 31, with five highlighting nucleotide metabolism as an important regulator of LTL. We report six genome-wide significant loci in or near SENP7, MOB1B, CARMIL1 , PRRC2A, TERF2, and RFWD3, and our results support recently identified PARP1, POT1, ATM, and MPHOSPH6 loci. Phenome-wide analyses in >350,000 UK Biobank participants suggest that genetically shorter telomere length increases the risk of hypothyroidism and decreases the risk of thyroid cancer, lymphoma, and a range of proliferative conditions. Our results replicate previously reported associations with increased risk of coronary artery disease and lower risk for multiple cancer types. Our findings substantially expand current knowledge on genes that regulate LTL and their impact on human health and disease. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
653 | a telomere length | |
653 | a biological aging | |
653 | a Mendelian randomisation | |
653 | a age-related disease | |
653 | a age-related disease | |
653 | a biological aging | |
653 | a Mendelian randomisation | |
653 | a telomere length | |
700 | 1 | a Stoma, Svetlanau Karolinska Institutet4 aut |
700 | 1 | a Lotta, Luca A.4 aut |
700 | 1 | a Warner, Sophie4 aut |
700 | 1 | a Albrecht, Eva4 aut |
700 | 1 | a Allione, Alessandra4 aut |
700 | 1 | a Arp, Pascal P.4 aut |
700 | 1 | a Broer, Linda4 aut |
700 | 1 | a Buxton, Jessica L.4 aut |
700 | 1 | a Da Silva Couto Alves, Alexessander4 aut |
700 | 1 | a Deelen, Joris4 aut |
700 | 1 | a Fedko, Iryna O.4 aut |
700 | 1 | a Gordon, Scott D.4 aut |
700 | 1 | a Jiang, Tao4 aut |
700 | 1 | a Karlsson, Robertu Karolinska Institutet4 aut |
700 | 1 | a Kerrison, Nicola4 aut |
700 | 1 | a Loe, Taylor K.4 aut |
700 | 1 | a Mangino, Massimo4 aut |
700 | 1 | a Milaneschi, Yuri4 aut |
700 | 1 | a Miraglio, Benjamin4 aut |
700 | 1 | a Pervjakova, Natalia4 aut |
700 | 1 | a Russo, Alessia4 aut |
700 | 1 | a Surakka, Ida4 aut |
700 | 1 | a van der Spek, Ashley4 aut |
700 | 1 | a Verhoeven, Josine E.4 aut |
700 | 1 | a Amin, Najaf4 aut |
700 | 1 | a Beekman, Marian4 aut |
700 | 1 | a Blakemore, Alexandra I.4 aut |
700 | 1 | a Canzian, Federico4 aut |
700 | 1 | a Hamby, Stephen E.4 aut |
700 | 1 | a Hottenga, Jouke-Jan4 aut |
700 | 1 | a Jones, Peter D.4 aut |
700 | 1 | a Jousilahti, Pekka4 aut |
700 | 1 | a Mägi, Reedik4 aut |
700 | 1 | a Medland, Sarah E.4 aut |
700 | 1 | a Montgomery, Grant W.4 aut |
700 | 1 | a Nyholt, Dale R.4 aut |
700 | 1 | a Perola, Markusu Finnish National Institute for Health and Welfare,University of Helsinki4 aut0 (Swepub:lu)med-mkp |
700 | 1 | a Pietiläinen, Kirsi H.4 aut |
700 | 1 | a Salomaa, Veikko4 aut |
700 | 1 | a Sillanpää, Elina4 aut |
700 | 1 | a Suchiman, H. Eka4 aut |
700 | 1 | a van Heemst, Diana4 aut |
700 | 1 | a Willemsen, Gonneke4 aut |
700 | 1 | a Agudo, Antonio4 aut |
700 | 1 | a Boeing, Heiner4 aut |
700 | 1 | a Boomsma, Dorret I.4 aut |
700 | 1 | a Chirlaque, Maria-Dolores4 aut |
700 | 1 | a Fagherazzi, Guy4 aut |
700 | 1 | a Ferrari, Pietro4 aut |
700 | 1 | a Franks, Paul W.u Umeå University,Lund University,Lunds universitet,Umeå universitet,Näringsforskning,Department of Clinical Sciences, Clinical Research Center, Skåne University Hospital, Lund University, 20502 Malmö Sweden,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-plf |
700 | 1 | a Gieger, Christian4 aut |
700 | 1 | a Eriksson, Johan Gunnaru National University of Singapore,Helsinki University Central Hospital,University of Helsinki4 aut0 (Swepub:lu)med-jeo |
700 | 1 | a Gunter, Marc4 aut |
700 | 1 | a Hagg, Sara4 aut |
700 | 1 | a Hovatta, Iiris4 aut |
700 | 1 | a Imaz, Liher4 aut |
700 | 1 | a Kaprio, Jaakko4 aut |
700 | 1 | a Kaaks, Rudolf4 aut |
700 | 1 | a Key, Timothy4 aut |
700 | 1 | a Krogh, Vittorio4 aut |
700 | 1 | a Martin, Nicholas G.4 aut |
700 | 1 | a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome |
700 | 1 | a Metspalu, Andres4 aut |
700 | 1 | a Moreno, Concha4 aut |
700 | 1 | a Onland-Moret, N. Charlotte4 aut |
700 | 1 | a Nilsson, Peteru Skåne University Hospital4 aut0 (Swepub:lu)medf-pni |
700 | 1 | a Ong, Ken K.4 aut |
700 | 1 | a Overvad, Kim4 aut |
700 | 1 | a Palli, Domenico4 aut |
700 | 1 | a Panico, Salvatore4 aut |
700 | 1 | a Pedersen, Nancy L.u Karolinska Institutet4 aut |
700 | 1 | a Penninx, Brenda W. J. H.4 aut |
700 | 1 | a Quirós, J. Ramón4 aut |
700 | 1 | a Riitta Jarvelin, Marjo4 aut |
700 | 1 | a Rodríguez-Barranco, Miguel4 aut |
700 | 1 | a Scott, Robert A.4 aut |
700 | 1 | a Severi, Gianluca4 aut |
700 | 1 | a Slagboom, P. Eline4 aut |
700 | 1 | a Spector, Tim D.4 aut |
700 | 1 | a Tjonneland, Anne4 aut |
700 | 1 | a Trichopoulou, Antonia4 aut |
700 | 1 | a Tumino, Rosario4 aut |
700 | 1 | a Uitterlinden, André G.4 aut |
700 | 1 | a van der Schouw, Yvonne T.4 aut |
700 | 1 | a van Duijn, Cornelia M.4 aut |
700 | 1 | a Weiderpass, Elisabete4 aut |
700 | 1 | a Denchi, Eros Lazzerini4 aut |
700 | 1 | a Matullo, Giuseppe4 aut |
700 | 1 | a Butterworth, Adam S.4 aut |
700 | 1 | a Danesh, John4 aut |
700 | 1 | a Samani, Nilesh J.4 aut |
700 | 1 | a Wareham, Nicholas J.4 aut |
700 | 1 | a Nelson, Christopher P.4 aut |
700 | 1 | a Langenberg, Claudia4 aut |
700 | 1 | a Codd, Veryanu University of Leicester,Glenfield Hospital4 aut |
710 | 2 | a Glenfield Hospitalb University of Cambridge4 org |
773 | 0 | t American Journal of Human Geneticsd : CELL PRESSg 106:3, s. 389-404q 106:3<389-404x 0002-9297x 1537-6605 |
856 | 4 | u https://doi.org/10.1016/j.ajhg.2020.02.006y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1420894/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u http://www.cell.com/article/S0002929720300483/pdf |
856 | 4 | u http://dx.doi.org/10.1016/j.ajhg.2020.02.006x freey FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-169391 |
856 | 4 8 | u https://doi.org/10.1016/j.ajhg.2020.02.006 |
856 | 4 8 | u https://lup.lub.lu.se/record/11710ffd-da84-4326-be0b-382b4af208ad |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:143190360 |
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