Integrated Network Analysis Reveals an Association between Plasma Mannose Levels and Insulin Resistance

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Integrated Network Analysis Reveals an Association between Plasma Mannose Levels and Insulin Resistance

Lee, Sunjae (author): KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab

Zhang, C. (author): KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab

Kilicarslan, M. (author): Universiteit Van Amsterdam,University of Amsterdam

Piening, B. D. (author): Stanford University

Björnson, Elias, 1988 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology

Hallström, Björn M. (author): KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab

Groen, A. K. (author): Rijksuniversiteit Groningen,University of Groningen

Ferrannini, E. (author): Istituto di Fisiologia Clinica del CNR

Laakso, M. (author): Itä-Suomen Yliopisto,University of Eastern Finland

Snyder, M. (author): Stanford University

Bluher, M. (author)

Uhlèn, Mathias (author): KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab

Nielsen, Jens B, 1962 (author): KTH,Genteknologi,Chalmers, Sweden

Smith, Ulf, 1943 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg

Serlie, M. J. (author): Universiteit Van Amsterdam,University of Amsterdam

Borén, Jan, 1963 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg

Mardinoglu, Adil, 1982 (author): Chalmers tekniska högskola,Chalmers University of Technology

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Elsevier BV, 2016
2016
English.
In: Cell Metabolism. - : Elsevier BV. - 1550-4131 .- 1932-7420. ; 24:1, s. 172-184

Related links:: http://www.cell.com/...; show more...; http://dx.doi.org/10...; https://gup.ub.gu.se...; https://doi.org/10.1...; https://research.cha...; https://urn.kb.se/re...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

To investigate the biological processes that are altered in obese subjects, we generated cell-specific integrated networks (INs) by merging genome-scale metabolic, transcriptional regulatory and protein-protein interaction networks. We performed genome-wide transcriptomics analysis to determine the global gene expression changes in the liver and three adipose tissues from obese subjects undergoing bariatric surgery and integrated these data into the cell-specific INs. We found dysregulations in mannose metabolism in obese subjects and validated our predictions by detecting mannose levels in the plasma of the lean and obese subjects. We observed significant correlations between plasma mannose levels, BMI, and insulin resistance (IR). We also measured plasma mannose levels of the subjects in two additional different cohorts and observed that an increased plasma mannose level was associated with IR and insulin secretion. We finally identified mannose as one of the best plasma metabolites in explaining the variance in obesity-independent IR.

Subject headings

NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Keyword

protein interaction networks
genome-scale
glucose-tolerance
metabolic
network
n-glycosylation
adipose-tissue
amino-acid
sensitivity
models
liver
Cell Biology
Endocrinology & Metabolism
protein interaction networks

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ref (subject category)
art (subject category)

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By the author/editor: Lee, Sunjae; Zhang, C.; Kilicarslan, M.; Piening, B. D.; Björnson, Elias, ...; Hallström, Björn ...; show more...; Groen, A. K.; Ferrannini, E.; Laakso, M.; Snyder, M.; Bluher, M.; Uhlèn, Mathias; Nielsen, Jens B, ...; Smith, Ulf, 1943; Serlie, M. J.; Borén, Jan, 1963; Mardinoglu, Adil ...; show less...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Cell Biology

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

Articles in the publication: Cell Metabolism

By the university: University of Gothenburg; Chalmers University of Technology; Royal Institute of Technology

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