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FältnamnIndikatorerMetadata
00007686naa a2200673 4500
001oai:DiVA.org:oru-69218
003SwePub
008181004s2018 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:139231780
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-692182 URI
0247 a https://doi.org/10.1194/jlr.S0871632 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1392317802 URI
040 a (SwePub)orud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Burla, Bou Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore4 aut
2451 0a MS-based lipidomics of human blood plasma :b a community-initiated position paper to develop accepted guidelines
264 1b American Society for Biochemistry and Molecular Biology,c 2018
338 a print2 rdacarrier
500 a Funding Agencies:National University of Singapore via the Life Sciences Institute  National Research Foundation Singapore Grant  NRFI2015-05 Deutsche Forschungsgemeinschaft  TRR83 LiSyM Consortium - Bundesministerium fur Bildung und Forschung, Germany  Foundation for the National Institutes of Health  U54 GM069338  RO1 GM20501-41 Japan Agency for Medical Research and Development Grant  JP18gm5910001 National Health and Medical Research Council of Australia  Japan Society for the Promotion of Science  15H05897  15H05898  17H03621 Japan Agency for Medical Research and Development Grants  17gm0910005h0403  17gm1010006h0001 National Bioscience Database Center Togo Project, Japan  Biotechnology and Biological Sciences Research Council Grant  BB/P013384/1 Medical Research Council Grant  MR/M004821/1 Academy of Finland Grant  292568 European Commission Project LITMUS Grant  777377 National Institute of General Medical Sciences Grant  R01 GM105724 
520 a Human blood is a self-regenerating lipid-rich biological fluid that is routinely collected in hospital settings. The inventory of lipid molecules found in blood plasma (plasma lipidome) offers insights into individual metabolism and physiology in health and disease. Disturbances in the plasma lipidome also occur in conditions that are not directly linked to lipid metabolism; therefore, plasma lipidomics based on MS is an emerging tool in an array of clinical diagnostics and disease management. However, challenges exist in the translation of such lipidomic data to clinical applications. These relate to the reproducibility, accuracy, and precision of lipid quantitation, study design, sample handling, and data sharing. This position paper emerged from a workshop that initiated a community-led process to elaborate and define a set of generally accepted guidelines for quantitative MS-based lipidomics of blood plasma or serum, with harmonization of data acquired on different instrumentation platforms across independent laboratories as an ultimate goal. We hope that other fields may benefit from and follow such a precedent.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Biomedicinsk laboratorievetenskap/teknologi0 (SwePub)304022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Biomedical Laboratory Science/Technology0 (SwePub)304022 hsv//eng
653 a National Institute of Standards and Technology Standard Reference Material 1950
653 a absolute concentrations
653 a clinical research
653 a clinical trials
653 a data sharing
653 a diagnostic tools
653 a lipids
653 a mass spectrometry
653 a quality control
7001 a Arita, Makotou Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Cellular and Molecular Epigenetics Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan; Division of Physiological Chemistry and Metabolism, Keio University Faculty of Pharmacy, Tokyo, Japan4 aut
7001 a Arita, Masanoriu National Institute of Genetics, Shizuoka, Japan and RIKEN Center for Sustainable Resource Science, Yokohama, Japan4 aut
7001 a Bendt, Anne K.u Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore4 aut
7001 a Cazenave-Gassiot, Amauryu Department of Biochemistry, YLL School of Medicine, National University of Singapore, Singapore4 aut
7001 a Dennis, Edward A.u Departments of Pharmacology and Chemistry and Biochemistry, School of Medicine, University of California at San Diego, La Jolla, CA, USA4 aut
7001 a Ekroos, Kimu Lipidomics Consulting Ltd., Esbo, Finland4 aut
7001 a Han, Xianlinu Barshop Institute for Longevity and Aging Studies and Department of Medicine-Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA4 aut
7001 a Ikeda, Kazutakau Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Cellular and Molecular Epigenetics Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan4 aut
7001 a Liebisch, Gerhardu Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany4 aut
7001 a Lin, Michelle K.u Department of Biochemistry, YLL School of Medicine, National University of Singapore, Singapore4 aut
7001 a Loh, Tze Pingu Department of Laboratory Medicine, National University Hospital, Singapore4 aut
7001 a Meikle, Peter J.u Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia4 aut
7001 a Orešič, Matej,d 1967-u Örebro universitet,Institutionen för medicinska vetenskaper,Turku Centre for Biotechnology, University of Turku, Turku, Finland; Åbo Akademi University, Turku, Finland4 aut0 (Swepub:oru)moc
7001 a Quehenberger, Oswaldu Departments of Pharmacology and Medicine, School of Medicine, University of California at San Diego, La Jolla, CA, USA4 aut
7001 a Shevchenko, Andreju Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany4 aut
7001 a Torta, Federicou Department of Biochemistry, YLL School of Medicine, National University of Singapore, Singapore4 aut
7001 a Wakelam, Michael J. O.u Babraham Institute, Cambridge, United Kingdom4 aut
7001 a Wheelock, Craig E.u Karolinska Institutet4 aut
7001 a Wenk, Markus R.u Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore; Department of Biochemistry, YLL School of Medicine, National University of Singapore, Singapore4 aut
7102 a Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singaporeb Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Cellular and Molecular Epigenetics Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan; Division of Physiological Chemistry and Metabolism, Keio University Faculty of Pharmacy, Tokyo, Japan4 org
7730 t Journal of Lipid Researchd : American Society for Biochemistry and Molecular Biologyg 59:10, s. 2001-2017q 59:10<2001-2017x 0022-2275x 1539-7262
8564 u https://doi.org/10.1194/jlr.S087163y Fulltext
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-69218
8564 8u https://doi.org/10.1194/jlr.S087163
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:139231780

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