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Plasma metabolomic profiles associated with mortality and longevity in a prospective analysis of 13,512 individuals

Wang, Fenglei (author)
Harvard School of Public Health, United States
Tessier, Anne Julie (author)
Harvard School of Public Health, United States
Liang, Liming (author)
Harvard School of Public Health, United States,Harvard School of Public Health, United States
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Wittenbecher, Clemens, 1981 (author)
Harvard School of Public Health, United States,Chalmers tekniska högskola,Chalmers University of Technology
Haslam, Danielle E. (author)
Harvard School of Public Health, United States,Brigham and Women's Hospital
Fernández-Duval, Gonzalo (author)
Universidad de Navarra,University of Navarra
Heather Eliassen, A. (author)
Harvard School of Public Health, United States,Brigham and Women's Hospital
Rexrode, Kathryn (author)
Brigham and Women's Hospital,Harvard Medical School
Tobias, Deirdre K. (author)
Harvard School of Public Health, United States,Brigham and Women's Hospital
Li, Jun (author)
Harvard School of Public Health, United States,Brigham and Women's Hospital
Zeleznik, Oana (author)
Brigham and Women's Hospital
Grodstein, Francine (author)
Rush University Medical Center
Martínez-González, Miguel A. (author)
Harvard School of Public Health, United States,Universidad de Navarra,University of Navarra
Salas-Salvadó, Jordi (author)
Universitat Rovira i Virgili,Rovira i Virgili University
Clish, Clary B. (author)
Broad Institute
Lee, Kyu Ha (author)
Harvard School of Public Health, United States,Harvard School of Public Health, United States,Harvard School of Public Health, United States
Sun, Qi (author)
Harvard School of Public Health, United States,Brigham and Women's Hospital
Stampfer, Meir J. (author)
Harvard School of Public Health, United States,Brigham and Women's Hospital
Hu, Frank B. (author)
Harvard School of Public Health, United States,Brigham and Women's Hospital
Guasch-Ferré, Marta (author)
Harvard School of Public Health, United States,Novo Nordisk Fonden,Novo Nordisk Foundation,Köpenhamns universitet,University of Copenhagen
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 (creator_code:org_t)
2023
2023
English.
In: Nature Communications. - 2041-1723 .- 2041-1723. ; 14:1
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https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Experimental studies reported biochemical actions underpinning aging processes and mortality, but the relevant metabolic alterations in humans are not well understood. Here we examine the associations of 243 plasma metabolites with mortality and longevity (attaining age 85 years) in 11,634 US (median follow-up of 22.6 years, with 4288 deaths) and 1878 Spanish participants (median follow-up of 14.5 years, with 525 deaths). We find that, higher levels of N2,N2-dimethylguanosine, pseudouridine, N4-acetylcytidine, 4-acetamidobutanoic acid, N1-acetylspermidine, and lipids with fewer double bonds are associated with increased risk of all-cause mortality and reduced odds of longevity; whereas L-serine and lipids with more double bonds are associated with lower mortality risk and a higher likelihood of longevity. We further develop a multi-metabolite profile score that is associated with higher mortality risk. Our findings suggest that differences in levels of nucleosides, amino acids, and several lipid subclasses can predict mortality. The underlying mechanisms remain to be determined.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

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