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Sökning: WFRF:(He Dongshuang) > (2017) > Intra-bone marrow i...

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FältnamnIndikatorerMetadata
00005700naa a2200517 4500
001oai:DiVA.org:uu-321173
003SwePub
008170512s2017 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3211732 URI
0247 a https://doi.org/10.1002/jbm.a.360272 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Yang, Xianyanu Zhejiang Univ, Zhejiang Calif Int Nanosyst Inst, Bionanomat & Regenerat Med Res Div, Yuhangtang Rd 866, Hangzhou 310058, Zhejiang, Peoples R China.4 aut
2451 0a Intra-bone marrow injection of trace elements co-doped calcium phosphate microparticles for the treatment of osteoporotic rat
264 c 2017-02-24
264 1b Wiley,c 2017
338 a print2 rdacarrier
520 a Osteoporotic femur fractures are the most common fragility fracture and account for approximately one million injuries per year. Local intervention by intra-marrow injection is potentially a good choice for preventing osteoporotic bone loss when the osteoporotic femoral fracture was treated. Previously, it was shown that trace element co-doped calcium phosphate (teCaP) implants could stimulate osteoporotic bone marrow mesenchymal stem cell activity in vitro and bone regeneration in femoral bone defects in osteoporotic animal models. They hypothesized that local intra-marrow injection of teCaP particles could improve bone function because the teCaP can sustain release of biologically essential inorganic minerals and improve bone remodeling in osteoporosis. The teCaP and CaP particles were synthesized in simulated body fluid with and without adding silicon, zinc and strontium ions. Female rats (8 months) were ovariectomized (OVX) or sham-operated, and then intervened in the femoral marrow space at 12 months old. Groups include: (1) saline water; (2) CaP particles; and (3) teCaP particles. After 2-3 months of intervention, the sham groups showed higher bone mineral density (MBD) in the femur, and teCaP group increased the BMD in the OVX groups. The compressive strength of the OVX-teCaP group was significantly higher than that in the OVX-CaP group. Significant differences between OVX-teCaP and OVX-CaP groups were found for bone mineral microarchitecture, bone mineral density, and trace mineral content, but not for feces composition. These results confirm the teCaP particles could suppress osteoporotic bone loss by local intramarrow injection. Therefore, this biomaterial could be used as a next-generation combination treatment for osteoporotic trauma and osteoporosis itself.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Biomaterialvetenskap0 (SwePub)304032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Biomaterials Science0 (SwePub)304032 hsv//eng
650 7a TEKNIK OCH TEKNOLOGIERx Materialteknik0 (SwePub)2052 hsv//swe
650 7a ENGINEERING AND TECHNOLOGYx Materials Engineering0 (SwePub)2052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Biomedicinsk laboratorievetenskap/teknologi0 (SwePub)304022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Biomedical Laboratory Science/Technology0 (SwePub)304022 hsv//eng
653 a antiosteoporosis
653 a trace element
653 a calcium phosphate
653 a local intramarrow injection
653 a osteoporotic fracture
7001 a Xu, Sanzhongu Zhejiang Univ, Affiliated Hosp 1, Dept Orthopaed Surg, Sch Med, Hangzhou 310003, Zhejiang, Peoples R China.4 aut
7001 a Chen, Xiaoyiu Zhejiang Univ, Zhejiang Calif Int Nanosyst Inst, Bionanomat & Regenerat Med Res Div, Yuhangtang Rd 866, Hangzhou 310058, Zhejiang, Peoples R China.;Zhejiang Prov Peoples Hosp, Clin Res Inst, Hangzhou 310014, Zhejiang, Peoples R China.4 aut
7001 a He, Dongshuangu Zhejiang Univ, Zhejiang Calif Int Nanosyst Inst, Bionanomat & Regenerat Med Res Div, Yuhangtang Rd 866, Hangzhou 310058, Zhejiang, Peoples R China.4 aut
7001 a Ke, Xiurongu Wenzhou Med Univ, Ruian Peoples Hosp, Ruian 325200, Peoples R China.;Wenzhou Med Univ, Hosp Affiliated 3, Ruian 325200, Peoples R China.4 aut
7001 a Zhang, Leiu Wenzhou Med Univ, Ruian Peoples Hosp, Ruian 325200, Peoples R China.;Wenzhou Med Univ, Hosp Affiliated 3, Ruian 325200, Peoples R China.4 aut
7001 a Yang, Guojingu Wenzhou Med Univ, Ruian Peoples Hosp, Ruian 325200, Peoples R China.;Wenzhou Med Univ, Hosp Affiliated 3, Ruian 325200, Peoples R China.4 aut
7001 a Liu, Anu Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Orthopaed Surg, Hangzhou 310009, Zhejiang, Peoples R China.4 aut
7001 a Mou, Xiaozhouu Zhejiang Prov Peoples Hosp, Clin Res Inst, Hangzhou 310014, Zhejiang, Peoples R China.4 aut
7001 a Xia, Weiu Uppsala universitet,Tillämpad materialvetenskap4 aut0 (Swepub:uu)weixi400
7001 a Gou, Zhongruu Zhejiang Univ, Zhejiang Calif Int Nanosyst Inst, Bionanomat & Regenerat Med Res Div, Yuhangtang Rd 866, Hangzhou 310058, Zhejiang, Peoples R China.4 aut
7102 a Zhejiang Univ, Zhejiang Calif Int Nanosyst Inst, Bionanomat & Regenerat Med Res Div, Yuhangtang Rd 866, Hangzhou 310058, Zhejiang, Peoples R China.b Zhejiang Univ, Affiliated Hosp 1, Dept Orthopaed Surg, Sch Med, Hangzhou 310003, Zhejiang, Peoples R China.4 org
7730 t Journal of Biomedical Materials Research. Part Ad : Wileyg 105:5, s. 1422-1432q 105:5<1422-1432x 1549-3296x 1552-4965
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-321173
8564 8u https://doi.org/10.1002/jbm.a.36027

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