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FältnamnIndikatorerMetadata
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0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-1076302 URI
0247 a https://doi.org/10.1289/EHP52512 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1422307902 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1623522 URI
040 a (SwePub)orud (SwePub)kid (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Li, Jiyunu Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China College of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan, China,China Agr Univ, Peoples R China; Hunan Agr Univ, Peoples R China4 aut
2451 0a Inter-host Transmission of Carbapenemase-Producing Escherichia coli among Humans and Backyard Animals
264 1b U.S. Department of Health and Human Services, National Institute of Environmental Health Sciences,c 2019
338 a print2 rdacarrier
500 a This study is funded by the National Natural Science Foundation of China (grants 81361138021, 81861138051, and 81661138002), National Key Research and Development Program of China (2018YFD0500300), the Swedish Research Council (Grant D0879801), and the Medical Research Council (MR/P007295/1). 
500 a Funding Agencies|National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81361138021, 81861138051, 81661138002]; National Key Research and Development Program of China [2018YFD0500300]; Swedish Research CouncilSwedish Research Council [D0879801]; Medical Research CouncilMedical Research Council UK (MRC) [MR/P007295/1]
520 a BACKGROUND: The rapidly increasing dissemination of carbapenem-resistant Enterobacteriaceae (CRE) in both humans and animals poses a global threat to public health. However, the transmission of CRE between humans and animals has not yet been well studied.OBJECTIVES: We investigated the prevalence, risk factors, and drivers of CRE transmission between humans and their backyard animals in rural China.METHODS: We conducted a comprehensive sampling strategy in 12 villages in Shandong, China. Using the household [residents and their backyard animals (farm and companion animals)] as a single surveillance unit, we assessed the prevalence of CRE at the household level and examined the factors associated with CRE carriage through a detailed questionnaire. Genetic relationships among human- and animal-derived CRE were assessed using whole-genome sequencing-based molecular methods.RESULTS: A total of 88 New Delhi metallo beta lactamasesmetallo-β-lactamases–type carbapenem-resistant Escherichia coli (NDM-EC), including 17 from humans, 44 from pigs, 12 from chickens, 1 from cattle, and 2 from dogs, were isolated from 65 of the 746 households examined. The remaining 12 NDM-EC were from flies in the immediate backyard environment. The NDM-EC colonization in households was significantly associated with a) the number of species of backyard animals raised/kept in the same household, and b) the use of human and/or animal feces as fertilizer. Discriminant analysis of principal components (DAPC) revealed that a large proportion of the core genomes of the NDM-EC belonged to strains from hosts other than their own, and several human isolates shared closely related core single-nucleotide polymorphisms and bla sub NDMblaNDM genetic contexts with isolates from backyard animals.CONCLUSIONS: To our knowledge, we are the first to report evidence of direct transmission of NDM-EC between humans and animals. Given the rise of NDM-EC in community and hospital infections, combating NDM-EC transmission in backyard farm systems is needed. https://doi.org/10.1289/EHP5251.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng
650 7a NATURVETENSKAPx Biologix Mikrobiologi0 (SwePub)106062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Microbiology0 (SwePub)106062 hsv//eng
650 7a NATURVETENSKAPx Biologix Annan biologi0 (SwePub)106992 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Other Biological Topics0 (SwePub)106992 hsv//eng
653 a Animals; Animals
653 a Domestic; Bacterial Proteins; beta-Lactamases; Carbapenem-Resistant Enterobacteriaceae; Cattle; China; Dogs; Drug Resistance
653 a Multiple
653 a Bacterial; Escherichia coli; Humans; Swine; Zoonoses
7001 a Bi, Zhenwangu Shandong Academy of Clinical Medicine, Shandong Provincial Hospital, Jinan, Shandong, China,Shandong Acad Clin Med, Peoples R China4 aut
7001 a Ma, Shizhenu Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China,China Agr Univ, Peoples R China4 aut
7001 a Chen, Baoliu Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Shandong Center for Disease Control and Prevention, Jinan, Shandong, China,Shandong Ctr Dis Control and Prevent, Peoples R China4 aut
7001 a Cai, Changu China Australia Joint Laboratory for Animal Health Big Data Analytics, College of Animal Science and Technology, Zhejiang Agricultural and Forestry University, Hangzhou, China Research and Innovation Office, Murdoch University, Murdoch, Australia,Zhejiang Agr and Forestry Univ, Peoples R China; Murdoch Univ, Australia4 aut
7001 a He, Junjiau Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China,China Agr Univ, Peoples R China4 aut
7001 a Schwarz, Stefanu Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China; Institute of Microbiology and Epizootics, Centre for Infection Medicine, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany,China Agr Univ, Peoples R China; Free Univ Berlin, Germany4 aut
7001 a Sun, Chengtaou Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China,China Agr Univ, Peoples R China4 aut
7001 a Zhou, Yuqingu Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China,China Agr Univ, Peoples R China4 aut
7001 a Yin, Jiau School of Health Care Management, Shandong University, Jinan, China; NHC Key Laboratory of Health Economics and Policy Research (Shandong University), Jinan, China,Shandong Univ, Peoples R China; Shandong Univ, Peoples R China4 aut
7001 a Hulth, Anetteu Karolinska Institutet,Karolinska Inst, Sweden; Publ Hlth Agcy Sweden, Sweden4 aut
7001 a Wang, Yongqiangu Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China,China Agr Univ, Peoples R China4 aut
7001 a Shen, Zhangqiu Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China,China Agr Univ, Peoples R China4 aut
7001 a Wang, Shaolinu Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China,China Agr Univ, Peoples R China4 aut
7001 a Wu, Congmingu Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China,China Agr Univ, Peoples R China4 aut
7001 a Nilsson, Lennart Eu Linköpings universitet,Avdelningen för mikrobiologi, infektion och inflammation,Medicinska fakulteten4 aut0 (Swepub:liu)lenni43
7001 a Walsh, Timothy Ru Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China; Department of Medical Microbiology and Infectious Disease, Division of Infection and Immunity, Cardiff University, Cardiff, UK,China Agr Univ, Peoples R China; Cardiff Univ, Wales4 aut
7001 a Börjesson, Stefan,d 1979-u Linköpings universitet,Avdelningen för mikrobiologi, infektion och inflammation,Medicinska fakulteten,Natl Vet Inst SVA, Sweden4 aut0 (Swepub:liu)stebo14
7001 a Shen, Jianzhongu Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China; Beijing Laboratory of Food Quality and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China,China Agr Univ, Peoples R China4 aut
7001 a Sun, Qiangu School of Health Care Management, Shandong University, Jinan, China; NHC Key Laboratory of Health Economics and Policy Research (Shandong University), Jinan, China,Shandong Univ, Peoples R China4 aut
7001 a Wang, Yangu Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing 100194, China,China Agr Univ, Peoples R China4 aut
7102 a Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China College of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan, Chinab China Agr Univ, Peoples R China; Hunan Agr Univ, Peoples R China4 org
7730 t Journal of Environmental Health Perspectivesd : U.S. Department of Health and Human Services, National Institute of Environmental Health Sciencesg 127:10q 127:10x 0091-6765x 1552-9924
8564 u https://doi.org/10.1289/EHP5251y Fulltext
8564 u https://liu.diva-portal.org/smash/get/diva2:1374026/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-107630
8564 8u https://doi.org/10.1289/EHP5251
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:142230790
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-162352

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