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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005103naa a2200505 4500
001oai:DiVA.org:uu-182021
003SwePub
008121002s2012 | |||||||||||000 ||eng|
009oai:slubar.slu.se:42537
009oai:prod.swepub.kib.ki.se:125151984
024a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1820212 URI
024a https://doi.org/10.1111/j.1467-2995.2012.00740.x2 DOI
024a https://res.slu.se/id/publ/425372 URI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1251519842 URI
040 a (SwePub)uud (SwePub)slud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Nyman, Görelu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjurens miljö och hälsa (HMH),Department of Animal Environment and Health4 aut0 (Swepub:slu)48285
2451 0a Pulsed delivery of inhaled nitric oxide counteracts hypoxaemia during 2.5 hours of inhalation anaesthesia in dorsally recumbent horses
264 1b Elsevier BV,c 2012
338 a print2 rdacarrier
520 a Objective The study aimed to investigate the effect of varying pulse lengths of inhaled nitric oxide (iNO), and 2.5 hours of continuous pulse-delivered iNO on pulmonary gas exchange in anaesthetized horses.Study Design Experimental study. Animals Six Standardbred horses.Methods Horses received acepromazine, detomidine, guaifenesin, thiopentone and isoflurane in oxygen, were positioned in dorsal recumbency and were breathing spontaneously. iNO was on average pulsed during the first 20, 30, 43 or 73% of the inspiration in 15 minute steps. The pulse length that corresponded to the highest (peak) partial pressure of arterial oxygen (PaO2) in the individual horses was determined and delivered for a further 1.5 hours. Data measured or calculated included arterial and mixed venous partial pressures of O2 and CO2, heart rate, respiratory rate, expired minute ventilation, pulmonary and systemic arterial mean pressures, cardiac output and venous admixture. Data (mean +/- SD) was analysed using anova with p < 0.05 considered significant.Results Although the pulse length of iNO that corresponded to peak PaO2 varied between horses, administration of all pulse lengths of iNO increased PaO2 compared to baseline. The shortest pulse lengths that resulted in the peak PaO2 were 30 and 43% of the inspiration. Administration of iNO increased PaO2 (12.6 +/- 4.1 kPa [95 +/- 31 mmHg] at baseline to a range of 23.0 +/- 8.4 to 25.3 +/- 9.0 kPa [173 to 190 mmHg]) and PaCO2 (8.5 +/- 1.2 kPa [64 +/- 9 mmHg] to 9.8 +/- 1.5 kPa [73 +/- 11 mmHg]) and decreased venous admixture from 32 +/- 6% to 25 +/- 6%. The increase in PaO2 and decrease in venous admixture was sustained for the entire 2.5 hours of iNO delivery.Conclusions The improvement in arterial oxygenation during pulsed delivery of iNO was significant and sustained throughout 2.5 hours of anaesthesia.Clinical relevance Pulsed iNO potentially could be used clinically to counteract hypoxemia in anaesthetized horses.
650 7a LANTBRUKSVETENSKAPERx Lantbruksvetenskap, skogsbruk och fiskex Jordbruksvetenskap0 (SwePub)401012 hsv//swe
650 7a AGRICULTURAL SCIENCESx Agriculture, Forestry and Fisheriesx Agricultural Science0 (SwePub)401012 hsv//eng
653 a horse
653 a nitric oxide
653 a gas exchange
653 a hypoxia
653 a anaesthesia
700a Grubb, Tamara L.u Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjurens miljö och hälsa (HMH),Department of Animal Environment and Health4 aut
700a Heinonen, Erkki4 aut
700a Frendin, Janu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences4 aut0 (Swepub:slu)51466
700a Edner, Annau Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences4 aut0 (Swepub:slu)50396
700a De Matos Malavasi, Laisu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences4 aut0 (Swepub:slu)52204
700a Frostell, Claesu Karolinska Institutet4 aut
700a Högman, Marieannu Uppsala universitet,Centrum för klinisk forskning, Gävleborg4 aut0 (Swepub:uu)marihogm
710a Sveriges lantbruksuniversitetb Institutionen för husdjurens miljö och hälsa (HMH)4 org
710a Sveriges lantbruksuniversitet
773t Veterinary Anaesthesia and Analgesiad : Elsevier BVg 39:5, s. 480-487q 39:5<480-487x 1467-2987x 1467-2995
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-182021
8564 8u https://doi.org/10.1111/j.1467-2995.2012.00740.x
8564 8u https://res.slu.se/id/publ/42537
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:125151984

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