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Genomics of adaptiv...
Genomics of adaptive evolution in the woolly mammoth
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- Díez-del-Molino, David, 1984- (author)
- Stockholms universitet,Arkeologi,Avdelningen för populationsgenetik,Centre for Palaeogenetics, Sweden; Swedish Museum of Natural History, Sweden
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- Dehasque, Marianne (author)
- Stockholms universitet,Zoologiska institutionen,Centre for Palaeogenetics, Sweden; Swedish Museum of Natural History, Sweden
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- Chacón-Duque, J. Camilo, 1988- (author)
- Stockholms universitet,Institutionen för arkeologi och antikens kultur,Centre for Palaeogenetics, Sweden
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Pecnerova, Patricia (author)
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Tikhonov, Alexei (author)
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Protopopov, Albert (author)
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Plotnikov, Valeri (author)
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Kanellidou, Foteini (author)
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Nikolskiy, Pavel (author)
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- Mortensen, Peter (author)
- Naturhistoriska riksmuseet,Enheten för zoologi
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Danilov, Gleb K. (author)
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Vartanyan, Sergey (author)
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Gilbert, M. Thomas P. (author)
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Lister, Adrian M. (author)
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- Heintzman, Peter, Dr. 1986- (author)
- Stockholms universitet,Institutionen för geologiska vetenskaper,Centre for Palaeogenetics, Sweden
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- van der Valk, Tom (author)
- Naturhistoriska riksmuseet,Enheten för bioinformatik och genetik
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- Dalén, Love, 1980- (author)
- Stockholms universitet,Institutionen för ekologi, miljö och botanik,Avdelningen för zoologisk ekologi,Centre for Palaeogenetics, Sweden; Swedish Museum of Natural History, Sweden
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Current Biology. - 0960-9822 .- 1879-0445. ; 33:9, s. 1753-1764
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Abstract
Subject headings
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- Ancient genomes provide a tool to investigate the genetic basis of adaptations in extinct organisms. However, the identification of species-specific fixed genetic variants requires the analysis of genomes from multiple individuals. Moreover, the long-term scale of adaptive evolution coupled with the short-term nature of tradi-tional time series data has made it difficult to assess when different adaptations evolved. Here, we analyze 23 woolly mammoth genomes, including one of the oldest known specimens at 700,000 years old, to identify fixed derived non-synonymous mutations unique to the species and to obtain estimates of when these mutations evolved. We find that at the time of its origin, the woolly mammoth had already acquired a broad spectrum of positively selected genes, including ones associated with hair and skin development, fat storage and metabolism, and immune system function. Our results also suggest that these phenotypes continued to evolve during the last 700,000 years, but through positive selection on different sets of genes. Finally, we also identify additional genes that underwent comparatively recent positive selection, including multiple genes related to skeletal morphology and body size, as well as one gene that may have contributed to the small ear size in Late Quaternary woolly mammoths.
Subject headings
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Díez-del-Molino, ...
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Dehasque, Marian ...
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Chacón-Duque, J. ...
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Pecnerova, Patri ...
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Tikhonov, Alexei
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Protopopov, Albe ...
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show more...
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Plotnikov, Valer ...
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Kanellidou, Fote ...
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Nikolskiy, Pavel
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Mortensen, Peter
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Danilov, Gleb K.
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Vartanyan, Serge ...
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Gilbert, M. Thom ...
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Lister, Adrian M ...
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Heintzman, Peter ...
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van der Valk, To ...
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Dalén, Love, 198 ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Evolutionary Bio ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
- Articles in the publication
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Current Biology
- By the university
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Stockholm University
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Karolinska Institutet
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Swedish Museum of Natural History