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Kidney injury molec...
Kidney injury molecule (KIM)-1 is associated with insulin resistance : results from two community-based studies of elderly individuals
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- Carlsson, Axel C (author)
- Karolinska Institutet,Uppsala universitet,Molekylär epidemiologi,Centre for Family Medicine, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden ; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
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- Calamia, Michael (author)
- Landstinget Dalarna, Falun, Sweden
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- Risérus, Ulf (author)
- Uppsala universitet,Klinisk nutrition och metabolism,Department of Public Health and Caring Sciences/Section of Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden
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- Larsson, Anders (author)
- Uppsala universitet,Biokemisk struktur och funktion,Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
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- Helmersson-Karlqvist, Johanna (author)
- Uppsala universitet,Biokemisk struktur och funktion,Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
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- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi,Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
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- Ärnlöv, Johan, 1970- (author)
- Uppsala universitet,Högskolan Dalarna,Medicinsk vetenskap,Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden,Molekylär epidemiologi
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(creator_code:org_t)
- Elsevier, 2014
- 2014
- English.
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In: Diabetes Research and Clinical Practice. - : Elsevier. - 0168-8227 .- 1872-8227. ; 103:3, s. 516-21
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Abstract
Subject headings
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- BACKGROUND AND OBJECTIVES: Insulin resistance has been shown to be closely associated with glomerular filtration rate and urinary albumin/creatinine ratio, even prior to the development of diabetes. Urinary kidney injury molecule 1 (KIM-1) is a novel, highly specific marker of kidney tubular damage. The role of insulin resistance in the development of kidney tubular damage is not previously reported. Thus, we aimed to investigate the associations between insulin sensitivity (assessed by HOMA) and urinary KIM-1.DESIGN, SETTING, PARTICIPANTS AND MEASUREMENTS: Two community-based cohorts of elderly individuals were investigated: Prospective Investigation of the vasculature in Uppsala seniors (PIVUS, n=701; mean age 75 years, 52% women); and Uppsala Longitudinal Study of adult men (ULSAM, n=533; mean age 78 years).RESULTS: Lower insulin sensitivity was associated with higher urinary KIM-1 in both cohorts after adjustments for age, BMI, blood pressure, antihypertensive treatment, glomerular filtration rate, and urinary albumin-creatinine ratio (PIVUS: regression coefficient for 1-SD higher HOMA-IR 0.11, 95% CI 0.03-0.20, p=0.009, and ULSAM: 0.13, 95% CI 0.04-0.22, p=0.007). Results were similar in individuals without diabetes, with normal kidney function and normo-albuminuria.CONCLUSIONS: Our findings in elderly individuals support the notion that the interplay between an impaired glucose metabolism and renal tubular damage is evident even prior to the development of diabetes and overt kidney disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Diabetes; Blood glucose; Microalbuminuria; Glomerular filtration; Kidney injury
- Hälsa och välfärd
- Health and Welfare
Publication and Content Type
- ref (subject category)
- art (subject category)
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