WFRF:(Hetty Susanne)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03881naa a2200481 4500 | |
| 001 | oai:DiVA.org:uu-483752 | |
| 003 | SwePub | |
| 008 | 220905s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4837522 URI |
| 024 | 7 | a https://doi.org/10.1080/21623945.2022.21021162 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Ahmed, Foziau Uppsala universitet,Klinisk diabetologi och metabolism4 aut0 (Swepub:uu)fozah903 |
| 245 | 1 0 | a ESR2 expression in subcutaneous adipose tissue is related to body fat distribution in women, and knockdown impairs preadipocyte differentiation |
| 264 | c 2022-08-17 | |
| 264 | 1 | b Informa UK Limited,c 2022 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Oestrogen receptor 2 (ESR2) expression has been shown to be higher in subcutaneous adipose tissue (SAT) from postmenopausal compared to premenopausal women. The functional significance of altered ESR2 expression is not fully known. This study investigates the role of ESR2 for adipose tissue lipid and glucose metabolism. SAT biopsies were obtained from 44 female subjects with or without T2D. Gene expression of ESR2 and markers of adipose function and metabolism was assessed. ESR2 knockdown was performed using CRISPR/Cas9 in preadipocytes isolated from SAT of females, and differentiation rate, lipid storage, and glucose uptake were measured. ESR2 expression was inversely correlated with measures of central obesity and expression of some fatty acid oxidation markers, and positively correlated with lipid storage and glucose transport markers. Differentiation was reduced in ESR2 knockdown preadipocytes. This corresponded to reduced expression of markers of differentiation and lipogenesis. Glucose uptake was reduced in knockdown adipocytes. Our results indicate that ESR2 deficiency in women is associated with visceral adiposity and impaired subcutaneous adipocyte differentiation as well as glucose and lipid utilization. High ESR2 expression, as seen after menopause, could be a contributing factor to SAT expansion. This may support a possible target to promote a healthy obesity phenotype. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 653 | a Adipocytes | |
| 653 | a adipogenesis | |
| 653 | a CRISPR | |
| 653 | a cas9 | |
| 653 | a lipid metabolism | |
| 653 | a obesity | |
| 653 | a insulin resistance | |
| 653 | a type 2 diabetes | |
| 700 | 1 | a Hetty, Susanne,c PhD,d 1979-u Uppsala universitet,Klinisk diabetologi och metabolism4 aut0 (Swepub:uu)sustr921 |
| 700 | 1 | a Vranic, Milicau Uppsala universitet,Klinisk diabetologi och metabolism4 aut0 (Swepub:uu)milvr380 |
| 700 | 1 | a Fanni, Giovanniu Uppsala universitet,Klinisk diabetologi och metabolism4 aut0 (Swepub:uu)giofa361 |
| 700 | 1 | a Kullberg, Joel,d 1979-u Uppsala universitet,Radiologi4 aut0 (Swepub:uu)jokul377 |
| 700 | 1 | a Pereira, Maria J.,d 1981-u Uppsala universitet,Klinisk diabetologi och metabolism4 aut0 (Swepub:uu)marpe927 |
| 700 | 1 | a Eriksson, Janu Uppsala universitet,Klinisk diabetologi och metabolism4 aut0 (Swepub:uu)janer909 |
| 710 | 2 | a Uppsala universitetb Klinisk diabetologi och metabolism4 org |
| 773 | 0 | t Adipocyted : Informa UK Limitedg 11:1, s. 434-447q 11:1<434-447x 2162-3945x 2162-397X |
| 856 | 4 | u https://doi.org/10.1080/21623945.2022.2102116y Fulltext |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1693032/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-483752 |
| 856 | 4 8 | u https://doi.org/10.1080/21623945.2022.2102116 |
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