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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 12877naa a2201213 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:139128695 | |
| 003 | SwePub | |
| 008 | 240924s2018 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:uu-419405 | |
| 009 | oai:lup.lub.lu.se:8600f211-2e5e-4877-a5bc-4923593e3a18 | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1391286952 URI |
| 024 | 7 | a https://doi.org/10.1038/s41467-018-04989-w2 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4194052 URI |
| 024 | 7 | a https://lup.lub.lu.se/record/8600f211-2e5e-4877-a5bc-4923593e3a182 URI |
| 040 | a (SwePub)kid (SwePub)uud (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Went, Mu Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.,Institute of Cancer Research London4 aut |
| 245 | 1 0 | a Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma |
| 264 | c 2018-09-13 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2018 |
| 520 | a Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained. We report a new GWAS, a meta-analysis with previous GWAS and a replication series, totalling 9974 MM cases and 247,556 controls of European ancestry. Collectively, these data provide evidence for six new MM risk loci, bringing the total number to 23. Integration of information from gene expression, epigenetic profiling and in situ Hi-C data for the 23 risk loci implicate disruption of developmental transcriptional regulators as a basis of MM susceptibility, compatible with altered B-cell differentiation as a key mechanism. Dysregulation of autophagy/apoptosis and cell cycle signalling feature as recurrently perturbed pathways. Our findings provide further insight into the biological basis of MM. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 700 | 1 | a Sud, Au Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.4 aut |
| 700 | 1 | a Försti, Astau Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,German Cancer Research Centre4 aut0 (Swepub:lu)med-asf |
| 700 | 1 | a Halvarsson, Britt-Marieu Lund University,Lunds universitet,Hematogenomics,Forskargrupper vid Lunds universitet,Lund University Research Groups4 aut0 (Swepub:lu)med-bhv |
| 700 | 1 | a Weinhold, Nu Univ Arkansas Med Sci, Myeloma Inst Res & Therapy, Little Rock, AR 72205 USA.;Heidelberg Univ, Dept Internal Med 5, D-69117 Heidelberg, Germany.4 aut |
| 700 | 1 | a Kimber, Su Inst Canc Res, Div Mol Pathol, London SW7 3RP, England.4 aut |
| 700 | 1 | a van Duin, Mu Erasmus MC, Dept Hematol, Canc Inst, NL-3075 EA Rotterdam, Netherlands.4 aut |
| 700 | 1 | a Thorleifsson, Gu deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland.4 aut |
| 700 | 1 | a Holroydl, Au Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.4 aut |
| 700 | 1 | a Johnson, DCu Inst Canc Res, Div Mol Pathol, London SW7 3RP, England.,German Canc Res Ctr, D-69120 Heidelberg, Germany.4 aut |
| 700 | 1 | a Li, Nu Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.4 aut |
| 700 | 1 | a Orlando, Gu Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.4 aut |
| 700 | 1 | a Law, PJu Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.,Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge CB1 8RN, England.;Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge CB1 8RN, England.,London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London WC1E 7HT, England.4 aut |
| 700 | 1 | a Ali, Minau Lund University,Lunds universitet,Hematogenomics,Forskargrupper vid Lunds universitet,Lund University Research Groups4 aut0 (Swepub:lu)med-ma16 |
| 700 | 1 | a Chen, BWu German Canc Res Ctr, D-69120 Heidelberg, Germany.4 aut |
| 700 | 1 | a Mitchell, JSu Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.4 aut |
| 700 | 1 | a Gudbjartsson, DFu deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland.;Univ Iceland, Sch Engn & Nat Sci, IS-101 Reykjavik, Iceland.4 aut |
| 700 | 1 | a Kuiper, Ru Erasmus MC, Dept Hematol, Canc Inst, NL-3075 EA Rotterdam, Netherlands.4 aut |
| 700 | 1 | a Stephens, OWu Univ Arkansas Med Sci, Myeloma Inst Res & Therapy, Little Rock, AR 72205 USA.4 aut |
| 700 | 1 | a Bertsch, Uu German Canc Res Ctr, D-69120 Heidelberg, Germany.;Natl Ctr Tumor Dis, D-69120 Heidelberg, Germany.4 aut |
| 700 | 1 | a Broderick, Pu Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.4 aut |
| 700 | 1 | a Campo, C4 aut |
| 700 | 1 | a Bandapalli, ORu German Canc Res Ctr, D-69120 Heidelberg, Germany.4 aut |
| 700 | 1 | a Einsele, Hu Univ Clin Wurzburg, D-97080 Wurzburg, Germany.4 aut |
| 700 | 1 | a Gregory, WAu Univ Leeds, Clin Trials Res Unit, Leeds LS2 9PH, W Yorkshire, England.,Norwegian Univ Sci & Technol, Dept Canc Res & Mol Med, Box 8905, N-7491 Trondheim, Norway.4 aut |
| 700 | 1 | a Gullberg, Urbanu Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Undersökning av molekylära sjukdomsmekanismer vid blodcancer,Forskargrupper vid Lunds universitet,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Transcriptional mechanisms for the Wilms’ tumor gene 1 (WT1) oncoprotein,Lund University Research Groups4 aut0 (Swepub:lu)efor-ugu |
| 700 | 1 | a Hillengass, Ju Heidelberg Univ, Dept Internal Med 5, D-69117 Heidelberg, Germany.,Royal Victoria Infirm, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England.4 aut |
| 700 | 1 | a Hoffmann, Pu Univ Bonn, Inst Human Genet, D-53127 Bonn, Germany.;Univ Basel, Dept Biomed, Divis Med Genet, CH-4003 Basel, Switzerland.4 aut |
| 700 | 1 | a Jackson, GHu Heidelberg Univ, Dept Internal Med 5, D-69117 Heidelberg, Germany.;Natl Ctr Tumor Dis, D-69120 Heidelberg, Germany.4 aut |
| 700 | 1 | a Hemminki, Kariu Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,German Cancer Research Centre4 aut0 (Swepub:lu)med-khk |
| 700 | 1 | a Johnsson, Ellinoru Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Hematogenomics,Forskargrupper vid Lunds universitet,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups4 aut0 (Swepub:lu)efor-ejo |
| 700 | 1 | a Kristinsson, SYu Natl Univ Hosp Iceland, Dept Hematol, Landspitali, IS-101 Reykjavik, Iceland.4 aut |
| 700 | 1 | a Mellqvist, UHu Sahlgrens Univ Hosp, Sect Hematol, S-41345 Gothenburg, Sweden.4 aut |
| 700 | 1 | a Nahi, Hu Karolinska Institutet,Ctr Hematol & Regenerat Med, SE-17177 Stockholm, Sweden.4 aut |
| 700 | 1 | a Easton, Du Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge CB1 8RN, England.;Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge CB1 8RN, England.,Univ Arkansas Med Sci, Myeloma Inst Res & Therapy, Little Rock, AR 72205 USA.4 aut |
| 700 | 1 | a Pharoah, P4 aut |
| 700 | 1 | a Dunning, Au Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge CB1 8RN, England.4 aut |
| 700 | 1 | a Peto, J4 aut |
| 700 | 1 | a Canzian, Fu German Canc Res Ctr, Gen Epidemiol Grp, D-69120 Heidelberg, Germany.4 aut |
| 700 | 1 | a Swerdlow, Au Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.;Inst Canc Res, Div Breast Canc Res, London SW7 3RP, England.4 aut |
| 700 | 1 | a Eeles, RAu Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.;Royal Marsden NHS Fdn Trust, Fulham Rd, London SW3 6JJ, England.4 aut |
| 700 | 1 | a Kote-Jarai, Zu Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.4 aut |
| 700 | 1 | a Muir, Ku Univ Manchester, Inst Populat Hlth, Manchester M13 9PL, Lancs, England.;Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, W Midlands, England.4 aut |
| 700 | 1 | a Pashayan, Nu Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge CB1 8RN, England.;UCL, Dept Appl Hlth Res, London WC1E 7HB, England.4 aut |
| 700 | 1 | a Nickel, Ju Heidelberg Univ, Dept Internal Med 5, D-69117 Heidelberg, Germany.4 aut |
| 700 | 1 | a Nothen, MMu Univ Bonn, Inst Human Genet, D-53127 Bonn, Germany.;Univ Bonn, Dept Genom, Life & Brain Ctr, D-53127 Bonn, Germany.4 aut |
| 700 | 1 | a Rafnar, Tu deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland.4 aut |
| 700 | 1 | a Ross, FMu Univ Southampton, Wessex Reg Genet Lab, Salisbury SP2 8BJ, Wilts, England.4 aut |
| 700 | 1 | a Filho, MIDu German Canc Res Ctr, D-69120 Heidelberg, Germany.4 aut |
| 700 | 1 | a Thomsen, Hu German Canc Res Ctr, D-69120 Heidelberg, Germany.4 aut |
| 700 | 1 | a Turesson, Iu Skane Univ Hosp, Hematol Clin, SE-22185 Lund, Sweden.4 aut |
| 700 | 1 | a Vangsted, Au Univ Copenhagen Hosp, Rigshosp, Dept Haematol, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.4 aut |
| 700 | 1 | a Andersen, NFu Aarhus Univ Hosp, Dept Haematol, Tage Hansens Gade 2, DK-8000 Aarhus C, Denmark.4 aut |
| 700 | 1 | a Waage, A4 aut |
| 700 | 1 | a Walker, BAu Univ Arkansas Med Sci, Myeloma Inst Res & Therapy, Little Rock, AR 72205 USA.,Erasmus MC, Dept Hematol, Canc Inst, NL-3075 EA Rotterdam, Netherlands.4 aut |
| 700 | 1 | a Wihlborg, Anna-Karinu Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Hematogenomics,Forskargrupper vid Lunds universitet,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups4 aut0 (Swepub:lu)kard-awi |
| 700 | 1 | a Broyl, A4 aut |
| 700 | 1 | a Davies, FE4 aut |
| 700 | 1 | a Thorsteinsdottir, Uu deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland.;Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland.4 aut |
| 700 | 1 | a Langer, Cu Univ Ulm, Dept Internal Med 3, D-89081 Ulm, Germany.4 aut |
| 700 | 1 | a Hansson, Markusu Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Myelomgruppen,Forskargrupper vid Lunds universitet,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Myeloma research group,Lund University Research Groups4 aut0 (Swepub:lu)hema-mha |
| 700 | 1 | a Goldschmidt, H4 aut |
| 700 | 1 | a Kaiser, Mu Inst Canc Res, Div Mol Pathol, London SW7 3RP, England.4 aut |
| 700 | 1 | a Sonneveld, Pu Erasmus MC, Dept Hematol, Canc Inst, NL-3075 EA Rotterdam, Netherlands.4 aut |
| 700 | 1 | a Stefansson, Ku deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland.4 aut |
| 700 | 1 | a Morgans, GJu Univ Arkansas Med Sci, Myeloma Inst Res & Therapy, Little Rock, AR 72205 USA.4 aut |
| 700 | 1 | a Hemminki, K4 aut |
| 700 | 1 | a Nilsson, Björnu Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Hematogenomics,Forskargrupper vid Lunds universitet,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups4 aut0 (Swepub:lu)klin-bni |
| 700 | 1 | a Houlston, RSu Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.;Inst Canc Res, Div Mol Pathol, London SW7 3RP, England.,Institute of Cancer Research London4 aut |
| 710 | 2 | a Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.b Institute of Cancer Research London4 org |
| 773 | 0 | t Nature communicationsd : Springer Science and Business Media LLCg 9:1, s. 3707-q 9:1<3707-x 2041-1723 |
| 856 | 4 | u https://www.nature.com/articles/s41467-018-04989-w.pdf |
| 856 | 4 | u http://dx.doi.org/10.1038/s41467-018-04989-wx freey FULLTEXT |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:139128695 |
| 856 | 4 8 | u https://doi.org/10.1038/s41467-018-04989-w |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419405 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/8600f211-2e5e-4877-a5bc-4923593e3a18 |
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