WFRF:(Holmäng Agneta)
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Effects of gender and GH secretory pattern on sterol regulatory element-binding protein-1c and its target genes in rat liver.
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- Améen, Caroline, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Wallenberglaboratoriet,Institute of Physiology and Pharmacology, Dept of Physiology,Wallenberg Laboratory
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- Lindén, Daniel, 1971 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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- Larsson, Britt-Mari, 1960 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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- (creator_code:org_t)
- American Physiological Society, 2004
- 2004
- English.
- In: American journal of physiology. Endocrinology and metabolism. - : American Physiological Society. - 0193-1849 .- 1522-1555. ; 287:6
- Journal article (peer-reviewed)
Abstract
Subject headings
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- We investigated whether the sexually dimorphic secretory pattern of growth hormone (GH) in the rat regulates hepatic gene expression of sterol regulatory element-binding protein-1c (SREBP-1c) and its target genes. SREBP-1c, fatty acid synthase (FAS), and glycerol-3-phosphate acyltransferase (GPAT) mRNA were more abundant in female than in male livers, whereas acetyl-CoA carboxylase-1 (ACC1) and stearoyl-CoA desaturase-1 (SCD-1) were similarly expressed in both sexes. Hypophysectomized female rats were given GH as a continuous infusion or as two daily injections for 7 days to mimic the female- and male-specific GH secretory patterns, respectively. The female pattern of GH administration increased the expression of SREBP-1c, ACC1, FAS, SCD-1, and GPAT mRNA, whereas the male pattern of GH administration increased only SCD-1 mRNA. FAS and SCD-1 protein levels were regulated in a similar manner by GH. Incubation of primary rat hepatocytes with GH increased SCD-1 mRNA levels and decreased FAS and GPAT mRNA levels but had no effect on SREBP-1c mRNA. GH decreased hepatic liver X receptor-alpha (LXRalpha) mRNA levels both in vivo and in vitro. Feminization of the GH plasma pattern in male rats by administration of GH as a continuous infusion decreased insulin sensitivity and increased expression of FAS and GPAT mRNA but had no effect on SREBP-1c, ACC1, SCD-1, or LXRalpha mRNA. In conclusion, FAS and GPAT are specifically upregulated by the female secretory pattern of GH. This regulation is not a direct effect of GH on hepatocytes and does not involve changed expression of SREBP-1c or LXRalpha mRNA but is associated with decreased insulin sensitivity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- Acetyl-CoA Carboxylase
- genetics
- Animals
- Antigens
- CD95
- genetics
- CCAAT-Enhancer-Binding Proteins
- genetics
- metabolism
- Cells
- Cultured
- DNA-Binding Proteins
- genetics
- metabolism
- Female
- Glycerol-3-Phosphate O-Acyltransferase
- genetics
- Growth Hormone
- blood
- pharmacology
- secretion
- Hepatocytes
- metabolism
- Insulin Resistance
- genetics
- Lipids
- biosynthesis
- Liver
- metabolism
- Male
- RNA
- Messenger
- metabolism
- Rats
- Rats
- Sprague-Dawley
- Receptors
- Cytoplasmic and Nuclear
- genetics
- Sex Characteristics
- Stearoyl-CoA Desaturase
- genetics
- Sterol Regulatory Element Binding Protein 1
- Transcription Factors
- genetics
- metabolism
Publication and Content Type
- ref (subject category)
- art (subject category)
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- University of Gothenburg
- Karolinska Institutet
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