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FältnamnIndikatorerMetadata
00006904naa a2200793 4500
001oai:gup.ub.gu.se/331453
003SwePub
008240528s2023 | |||||||||||000 ||eng|
009oai:DiVA.org:oru-108380
009oai:lup.lub.lu.se:36af9e36-7412-4919-b094-fb37aa6caaa1
009oai:prod.swepub.kib.ki.se:237725590
0247 a https://gup.ub.gu.se/publication/3314532 URI
0247 a https://doi.org/10.1089/thy.2023.01622 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-1083802 URI
0247 a https://lup.lub.lu.se/record/36af9e36-7412-4919-b094-fb37aa6caaa12 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:2377255902 URI
040 a (SwePub)gud (SwePub)orud (SwePub)lud (SwePub)ki
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Khamisi, Selwanu Uppsala University,Uppsala University Hospital4 aut
2451 0a Fracture Incidence in Graves' Disease: A Population-Based Study.
264 1b Mary Ann Liebert,c 2023
520 a Background: Population-based studies have indicated an increase in bone turnover in hyperthyroidism with a subsequent decrease in bone mineral density and an increased risk of fractures, especially in postmenopausal women. However, heterogeneity between studies prevents a definitive conclusion. Graves' disease (GD) is an autoimmune disease, and it is the most common cause of hyperthyroidism. The aim of this study was to investigate fracture risk in patients with GD. Methods: A total of 2134 patients with incident GD and 21,261 age, sex- and county-matched controls were included 16-18 years after diagnosis in a retrospective cohort study. Drug and patient national registries in Sweden were used to assess the risk of developing skeletal complications. Up to 10 years of age, sex- and county-matched controls per patient were selected from databases from the National Board of Health and Welfare and Statistics Sweden. Cox proportional hazards models were fitted to estimate hazard ratios (HR) and confidence intervals [CI]. Results: There were no significant differences in fracture rates between GD and controls but after adjustment for comorbidities, the data showed higher vertebral fracture rates in male GD patients aged >52 years compared to male controls, HR=2.83 [CI 1.05-7.64]. The rates of osteoporosis treatments as well as treatment with corticosteroids were higher in patients with GD. However, HR for the association between GD and fractures remained largely unchanged after adjustment for osteoporosis treatments and treatments with corticosteroids. Conclusions: There were no significant differences in total fracture rate between GD and the general population. However, men older than 52 years had a higher vertebral fracture rate. This study also shows that patients with treated GD receive more osteoporosis treatments compared to the general population.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Ortopedi0 (SwePub)302112 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Orthopaedics0 (SwePub)302112 hsv//eng
653 a Humans
653 a Male
653 a Female
653 a Spinal Fractures
653 a complications
653 a Incidence
653 a Retrospective Studies
653 a Fractures
653 a Bone
653 a epidemiology
653 a etiology
653 a Graves Disease
653 a complications
653 a drug therapy
653 a epidemiology
653 a Hyperthyroidism
653 a complications
653 a Osteoporosis
653 a complications
653 a epidemiology
653 a Adrenal Cortex Hormones
7001 a Udumyan, Ruzan,d 1971-u Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län4 aut0 (Swepub:oru)run
7001 a Sjölin, Gabriel,d 1979-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Surgery,Örebro University Hospital4 aut0 (Swepub:oru)glsn
7001 a Calissendorff, Janu Karolinska Institutet,Karolinska Institute4 aut
7001 a Nyström, Helena Filipsson,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Sahlgrenska Academy, 70712, Dept. of Endocrinology, Sahlgrenska University Hospital, Goteborg, Sweden4 aut0 (Swepub:gu)xfilih
7001 a Holmberg, Mikael,d 1950u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut
7001 a Hallengren, Bengtu Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)endo-bha
7001 a Lantz, Mikaelu Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)endo-mla
7001 a Planck, Terezau Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)endo-tvo
7001 a Wallin, Göran,d 1952-u Örebro University,Karolinska Institute,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Karolinska Institutet, 27106, Department of Molecular Medicine and Surgery, Stockholm, Sweden; Departgment of Surgery4 aut0 (Swepub:oru)gwn
7001 a Ljunggren, Östenu Uppsala University4 aut
7001 a Holmberg, Matsu Sahlgrenska Academy, 70712, Goteborg, Sweden4 aut
7102 a Uppsala Universityb Uppsala University Hospital4 org
7730 t Thyroid : official journal of the American Thyroid Associationd : Mary Ann Liebertg 33:11, s. 1349-1357q 33:11<1349-1357x 1557-9077x 1050-7256
8564 u http://dx.doi.org/10.1089/thy.2023.0162y FULLTEXT
8564 8u https://gup.ub.gu.se/publication/331453
8564 8u https://doi.org/10.1089/thy.2023.0162
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-108380
8564 8u https://lup.lub.lu.se/record/36af9e36-7412-4919-b094-fb37aa6caaa1
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:237725590

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