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Age-dependent impac...
Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality
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- Nakanishi, Tomoko (author)
- Univ Helsinki, Inst Mol Med Finland, Helsinki, Finland.;McGill Univ, Dept Human Genet, Montreal, PQ, Canada.;McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;Kyoto Univ, Grad Sch Med, Kyoto McGill Int Collaborat Sch Genom Med, Kyoto, Japan.;Japan Soc Promot Sci, Tokyo, Japan.
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- Pigazzini, Sara (author)
- Univ Helsinki, Inst Mol Med Finland, Helsinki, Finland.;Univ Milano Bicocca, Milan, Italy.
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- Degenhardt, Frauke (author)
- Univ Kiel, Inst Clin Mol Biol, Kiel, Germany.
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- Cordioli, Mattia (author)
- Univ Helsinki, Inst Mol Med Finland, Helsinki, Finland.
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- Butler-Laporte, Guillaume (author)
- McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.
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- Maya-Miles, Douglas (author)
- Univ Seville, Virgen del Rocio Univ Hosp, Inst Biomed Seville, Digest Dis Unit, Seville, Spain.;Inst Salud Carlos Iii ISCIII, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain.
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- Bujanda, Luis (author)
- Univ Basque Country UPV EHU, Biodonostia Hlth Res Inst, Dept Liver & Gastrointestinal Dis, Donostia Univ Hosp,CIBERehd,Ikerbasque, San Sebastian, Spain.
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- Bouysran, Youssef (author)
- Univ Libre Bruxelles ULB, Ctr Genet Humaine, Hop Erasme, Brussels, Belgium.
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- Niemi, Mari E. K. (author)
- Univ Helsinki, Inst Mol Med Finland, Helsinki, Finland.
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- Palom, Adriana (author)
- Hosp Univ Vall dHebron, Dept Internal Med, Liver Unit, Vall dHebron Barcelona Hosp Campus, Barcelona, Spain.;Univ Autonoma Barcelona, Dept Med Bellatera, Barcelona, Spain.;Vall dHebron Inst Recerca VHIR, Liver Dis, Barcelona, Spain.
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- Ellinghaus, David (author)
- Univ Kiel, Inst Clin Mol Biol, Kiel, Germany.;Univ Copenhagen, Novo Nordisk Fdn Ctr Prot Res, Fac Hlth & Med Sci, Dis Syst Biol, Copenhagen, Denmark.
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- Khan, Atlas (author)
- Columbia Univ, Vagelos Coll Phys & Surg, Dept Med, Div Nephrol, New York, NY USA.
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- Martinez-Bueno, Manuel (author)
- Univ Granada, GENYO, Ctr Genom & Oncol Res Pfizer, Andalusian Reg Govt, Granada, Spain.
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- Rolker, Selina (author)
- Univ Bonn, Med Fac, Inst Human Genet, Univ Hosp Bonn, Bonn, Germany.
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- Amitrano, Sara (author)
- Azienda Osped Univ Senese, Genet Med, Siena, Italy.
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- Roade Tato, Luisa (author)
- Inst Salud Carlos Iii ISCIII, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain.;Hosp Univ Vall dHebron, Dept Internal Med, Liver Unit, Vall dHebron Barcelona Hosp Campus, Barcelona, Spain.;Univ Autonoma Barcelona, Dept Med Bellatera, Barcelona, Spain.
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- Fava, Francesca (author)
- Azienda Osped Univ Senese, Genet Med, Siena, Italy.;Univ Siena, Med Genet, Siena, Italy.;Univ Siena, Med Biotech Hub, Dept Med Biotechnol, Siena, Italy.;Univ Siena, Competence Ctr, Dept Med Biotechnol, Siena, Italy.
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- Spinner, Christoph D. (author)
- Tech Univ Munich, Univ Hosp Rechts Isar, Sch Med, Dept Internal Med 2, Munich, Germany.
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- Prati, Daniele (author)
- Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Transfus Med & Hematol, Milan, Italy.
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- Bernardo, David (author)
- Inst Salud Carlos Iii ISCIII, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain.;Univ Valladolid, Inst Biomed & Mol Genet IBGM, Mucosal Immunol Lab, CSIC, Valladolid, Spain.
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- Garcia, Federico (author)
- Hosp Univ Clin San Cecilio, Granada, Spain.;Inst Invest Ibs Granada, Granada, Spain.
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- Darcis, Gilles (author)
- Univ Liege, GIGA Insitute, Liege, Belgium.;Liege Univ Hosp CHU Liege, Liege, Belgium.
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- Fernandez-Cadenas, Israel (author)
- Biomed Res Inst St Pau IIB St Pau, Stroke Pharmacogen & Genet Grp, Barcelona, Spain.
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- Holter, Jan Cato (author)
- Oslo Univ Hosp, Dept Microbiol, Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway.
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- Banales, Jesus M. (author)
- Univ Basque Country UPV EHU, Biodonostia Hlth Res Inst, Dept Liver & Gastrointestinal Dis, Donostia Univ Hosp,CIBERehd,Ikerbasque, San Sebastian, Spain.;Univ Navarra, Sch Sci, Dept Biochem & Genet, Pamplona, Spain.
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- Frithiof, Robert (author)
- Uppsala universitet,Anestesiologi och intensivvård
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- Kiryluk, Krzysztof (author)
- Columbia Univ, Vagelos Coll Phys & Surg, Dept Med, Div Nephrol, New York, NY USA.
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- Duga, Stefano (author)
- Humanitas Univ, Dept Biomed Sci, Milan, Italy.;IRCCS Humanitas Res Hosp, Milan, Italy.
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- Asselta, Rosanna (author)
- Humanitas Univ, Dept Biomed Sci, Milan, Italy.;IRCCS Humanitas Res Hosp, Milan, Italy.
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- Pereira, Alexandre C. (author)
- Univ Sao Paulo, Med Sch, Heart Inst InCor, Sao Paulo, Brazil.
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- Romero-Gomez, Manuel (author)
- Univ Seville, Virgen del Rocio Univ Hosp, Inst Biomed Seville, Digest Dis Unit, Seville, Spain.;Inst Salud Carlos Iii ISCIII, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain.
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- Nafria-Jimenez, Beatriz (author)
- Osakidetza Basque Hlth Serv, Donostialdea Integrated Hlth Org, Clin Biochem Dept, Sebastian, Spain.
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- Hov, Johannes R. (author)
- Oslo Univ Hosp, Dept Microbiol, Oslo, Norway.;Oslo Univ Hosp, Norwegian PSC Res Ctr, Oslo, Norway.;Oslo Univ Hosp, Sect Gastroenterol, Dept Transplantat Med, Oslo, Norway.;Oslo Univ Hosp, Res Inst Internal Med, Oslo, Norway.
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- Migeotte, Isabelle (author)
- Univ Libre Bruxelles ULB, Ctr Genet Humaine, Hop Erasme, Brussels, Belgium.;Fonds Rech Sci FNRS, Brussels, Belgium.
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- Renieri, Alessandra (author)
- Azienda Osped Univ Senese, Genet Med, Siena, Italy.;Univ Siena, Med Genet, Siena, Italy.;Univ Siena, Med Biotech Hub, Dept Med Biotechnol, Siena, Italy.;Univ Siena, Competence Ctr, Dept Med Biotechnol, Siena, Italy.
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- Planas, Anna M. (author)
- Natl Spanish Res Council CSIC, Inst Biomed Researhc Barcelona IIBB, Barcelona, Spain.;Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.
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- Ludwig, Kerstin U. (author)
- Univ Bonn, Med Fac, Inst Human Genet, Univ Hosp Bonn, Bonn, Germany.
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- Buti, Maria (author)
- Inst Salud Carlos Iii ISCIII, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain.;Hosp Univ Vall dHebron, Dept Internal Med, Liver Unit, Vall dHebron Barcelona Hosp Campus, Barcelona, Spain.;Univ Autonoma Barcelona, Dept Med Bellatera, Barcelona, Spain.
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- Rahmouni, Souad (author)
- Inst Invest Ibs Granada, Granada, Spain.
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- Alarcon-Riquelme, Marta E. (author)
- Karolinska Institutet
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- Schulte, Eva C. (author)
- Tech Univ Munich, Inst Virol, Helmholtz Zentrum Munchen, Munich, Germany.;LMU Munich Univ, Univ Hosp, Inst Psychiat Phen & Genom, Munich, Germany.;LMU Munich Univ, Univ Hosp, Dept Psychiat, Munich, Germany.
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- Franke, Andre (author)
- Univ Kiel, Inst Clin Mol Biol, Kiel, Germany.;Univ Hosp Schleswig Holstein, Campus Kiel, Kiel, Germany.
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- Karlsen, Tom H. (author)
- Univ Oslo, Inst Clin Med, Oslo, Norway.;Oslo Univ Hosp, Norwegian PSC Res Ctr, Oslo, Norway.;Oslo Univ Hosp, Sect Gastroenterol, Dept Transplantat Med, Oslo, Norway.;Oslo Univ Hosp, Res Inst Internal Med, Oslo, Norway.
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- Valenti, Luca (author)
- Univ Milan, Dept Pathophysiol & Transplantat, Milan, Italy.;Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Transfus Med & Hematol, Precis Med, Milan, Italy.
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- Zeberg, Hugo (author)
- Karolinska Institutet
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- Richards, J. Brent (author)
- McGill Univ, Dept Human Genet, Montreal, PQ, Canada.;McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;Univ Seville, Virgen del Rocio Univ Hosp, Inst Biomed Seville, Digest Dis Unit, Seville, Spain.;Kings Coll London, Dept Twin Res, London, England.
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- Ganna, Andrea (author)
- Univ Helsinki, Inst Mol Med Finland, Helsinki, Finland.;Harvard Med Sch, Massachusetts Gen Hosp, Boston, MA 02115 USA.
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- Karlsson, Philip (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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Univ Helsinki, Inst Mol Med Finland, Helsinki, Finland;McGill Univ, Dept Human Genet, Montreal, PQ, Canada.;McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;Kyoto Univ, Grad Sch Med, Kyoto McGill Int Collaborat Sch Genom Med, Kyoto, Japan.;Japan Soc Promot Sci, Tokyo, Japan. Univ Helsinki, Inst Mol Med Finland, Helsinki, Finland.;Univ Milano Bicocca, Milan, Italy. (creator_code:org_t)
- American Society For Clinical Investigation, 2021
- 2021
- English.
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In: Journal of Clinical Investigation. - : American Society For Clinical Investigation. - 0021-9738 .- 1558-8238. ; 131:23
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND. There is considerable variability in COVID-19 outcomes among younger adults, and some of this variation may be due to genetic predisposition. METHODS. We combined individual level data from 13,888 COVID-19 patients (n = 7185 hospitalized) from 17 cohorts in 9 countries to assess the association of the major common COVID-19 genetic risk factor (chromosome 3 locus tagged by rs10490770) with mortality, COVID-19-related complications, and laboratory values. We next performed metaanalyses using FinnGen and the Columbia University COVID-19 Biobank. RESULTS. We found that rs10490770 risk allele carriers experienced an increased risk of all-cause mortality (HR, 1.4; 95% CI, 1.2-1.7). Risk allele carriers had increased odds of several COVID-19 complications: severe respiratory failure (OR, 2.1; 95% CI, 1.6-2.6), venous thromboembolism (OR, 1.7; 95% CI, 1.2-2.4), and hepatic injury (OR, 1.5; 95% CI, 1.2-2.0). Risk allele carriers age 60 years and younger had higher odds of death or severe respiratory failure (OR, 2.7; 95% CI, 1.8-3.9) compared with those of more than 60 years (OR, 1.5; 95% CI, 1.2-1.8; interaction, P = 0.038). Among individuals 60 years and younger who died or experienced severe respiratory failure, 32.3% were risk-variant carriers compared with 13.9% of those not experiencing these outcomes. This risk variant improved the prediction of death or severe respiratory failure similarly to, or better than, most established clinical risk factors. CONCLUSIONS. The major common COVID-19 genetic risk factor is associated with increased risks of morbidity and mortality, which are more pronounced among individuals 60 years or younger. The effect was similar in magnitude and more common than most established clinical risk factors, suggesting potential implications for future clinical risk management.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
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Nakanishi, Tomok ...
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Pigazzini, Sara
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Degenhardt, Frau ...
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Cordioli, Mattia
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Butler-Laporte, ...
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Maya-Miles, Doug ...
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show more...
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Bujanda, Luis
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Bouysran, Yousse ...
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Niemi, Mari E. K ...
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Palom, Adriana
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Ellinghaus, Davi ...
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Khan, Atlas
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Martinez-Bueno, ...
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Rolker, Selina
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Amitrano, Sara
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Roade Tato, Luis ...
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Fava, Francesca
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Spinner, Christo ...
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Prati, Daniele
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Bernardo, David
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Garcia, Federico
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Darcis, Gilles
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Fernandez-Cadena ...
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Holter, Jan Cato
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Banales, Jesus M ...
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Frithiof, Robert
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Kiryluk, Krzyszt ...
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Duga, Stefano
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Asselta, Rosanna
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Pereira, Alexand ...
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Romero-Gomez, Ma ...
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Nafria-Jimenez, ...
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Hov, Johannes R.
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Migeotte, Isabel ...
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Renieri, Alessan ...
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Planas, Anna M.
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Ludwig, Kerstin ...
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Buti, Maria
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Rahmouni, Souad
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Alarcon-Riquelme ...
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Schulte, Eva C.
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Franke, Andre
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Karlsen, Tom H.
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Valenti, Luca
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Zeberg, Hugo
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Richards, J. Bre ...
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Ganna, Andrea
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Karlsson, Philip
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MEDICAL AND HEAL ...
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Uppsala University
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Karolinska Institutet