WFRF:(Honkura Naoki)
Sökning: WFRF:(Honkura Naoki) > Intravital imaging-...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03600naa a2200397 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:138739335 | |
| 003 | SwePub | |
| 008 | 240701s2018 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:uu-361698 | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1387393352 URI |
| 024 | 7 | a https://doi.org/10.1038/s41467-018-04929-82 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3616982 URI |
| 040 | a (SwePub)kid (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Honkura, Naokiu Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)naoho135 |
| 245 | 1 0 | a Intravital imaging-based analysis tools for vessel identification and assessment of concurrent dynamic vascular events |
| 264 | c 2018-07-16 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2018 |
| 520 | a The vasculature undergoes changes in diameter, permeability and blood flow in response to specific stimuli. The dynamics and interdependence of these responses in different vessels are largely unknown. Here we report a non-invasive technique to study dynamic events in different vessel categories by multi-photon microscopy and an image analysis tool, RVDM (relative velocity, direction, and morphology) allowing the identification of vessel categories by their red blood cell (RBC) parameters. Moreover, Claudin5 promoter-driven green fluorescent protein (GFP) expression is used to distinguish capillary subtypes. Intradermal injection of vascular endothelial growth factor A (VEGFA) is shown to induce leakage of circulating dextran, with vessel-type-dependent kinetics, from capillaries and venules devoid of GFP expression. VEGFA-induced leakage in capillaries coincides with vessel dilation and reduced flow velocity. Thus, intravital imaging of non-invasive stimulation combined with RVDM analysis allows for recording and quantification of very rapid events in the vasculature. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
| 700 | 1 | a Richards, Marku Uppsala universitet,Science for Life Laboratory, SciLifeLab,Vaskulärbiologi4 aut0 (Swepub:uu)marri386 |
| 700 | 1 | a Laviña, Bàrbarau Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)barsi852 |
| 700 | 1 | a Sainz-Jaspeado, Miguelu Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)migsa268 |
| 700 | 1 | a Betsholtz, Christeru Uppsala universitet,Karolinska Institutet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)chbet517 |
| 700 | 1 | a Claesson-Welsh, Lenau Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)lcl04207 |
| 710 | 2 | a Uppsala universitetb Vaskulärbiologi4 org |
| 773 | 0 | t Nature communicationsd : Springer Science and Business Media LLCg 9:1, s. 2746-q 9:1<2746-x 2041-1723 |
| 856 | 4 | u https://www.nature.com/articles/s41467-018-04929-8.pdf |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1251274/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:138739335 |
| 856 | 4 8 | u https://doi.org/10.1038/s41467-018-04929-8 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-361698 |
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