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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003725naa a2200397 4500
001oai:DiVA.org:oru-56454
003SwePub
008170316s2014 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-564542 URI
0247 a https://doi.org/10.1128/AAC.03090-142 DOI
040 a (SwePub)oru
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Jacobsson, Susanne,d 1974-u Region Örebro län,National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)sajn
2451 0a High In Vitro Activity of the Novel Spiropyrimidinetrione AZD0914, a DNA Gyrase Inhibitor, against Multidrug-Resistant Neisseria gonorrhoeae Isolates Suggests a New Effective Option for Oral Treatment of Gonorrhea
264 1b American Society for Microbiology,c 2014
338 a print2 rdacarrier
500 a Funding Agencies:Örebro County Council Research CommitteeFoundation for Medical Research at Örebro University Hospital, SwedenInfection iMed, AstraZeneca Pharmaceuticals LP, Waltham, MA
520 a We evaluated the activity of the novel spiropyrimidinetrione AZD0914 (DNA gyrase inhibitor) against clinical gonococcal isolates and international reference strains (n = 250), including strains with diverse multidrug resistance and extensive drug resistance. The AZD0914 MICs were substantially lower than those of most other currently or previously recommended antimicrobials. AZD0914 should be further evaluated, including in vitro selection, in vivo emergence and mechanisms of resistance, pharmacokinetics/pharmacodynamics in humans, optimal dosing, and performance, in appropriate randomized and controlled clinical trials.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng
7001 a Golparian, Daniel,d 1984-u National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)degn
7001 a Alm, Richard A.u Infection IMed, AstraZeneca RandD Boston, Waltham MA, United States4 aut
7001 a Huband, Michaelu Infection IMed, AstraZeneca RandD Boston, Waltham MA, United States4 aut
7001 a Mueller, Johnu Infection IMed, AstraZeneca RandD Boston, Waltham MA, United States4 aut
7001 a Jensen, Jorgen Skovu Statens Serum Institut, Copenhagen, Denmark4 aut
7001 a Ohnishi, Makotou National Institute of Infectious Diseases, Tokyo, Japan4 aut
7001 a Unemo, Magnus,d 1970-u Region Örebro län,National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)muo
7102 a Region Örebro länb National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden4 org
7730 t Antimicrobial Agents and Chemotherapyd : American Society for Microbiologyg 58:9, s. 5585-5588q 58:9<5585-5588x 0066-4804x 1098-6596
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-56454
8564 8u https://doi.org/10.1128/AAC.03090-14

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