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Sökning: WFRF:(Huhtakangas Juha) > Gordin Daniel > Searching for Expla...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007334naa a2200973 4500
001oai:lup.lub.lu.se:fce74cee-9719-46fa-9df6-ccf15e744f68
003SwePub
008190211s2017 | |||||||||||000 ||eng|
009oai:gup.ub.gu.se/266256
0247 a https://lup.lub.lu.se/record/fce74cee-9719-46fa-9df6-ccf15e744f682 URI
0247 a https://doi.org/10.1177/23969873177032102 DOI
0247 a https://gup.ub.gu.se/publication/2662562 URI
040 a (SwePub)lud (SwePub)gu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Putaala, Jukkau Helsinki University Central Hospital4 aut
2451 0a Searching for Explanations for Cryptogenic Stroke in the Young : Revealing the Triggers, Causes, and Outcome (SECRETO): Rationale and design
264 c 2017-04-04
264 1b SAGE Publications,c 2017
300 a 10 s.
520 a Background: Worldwide, about 1.3 million annual ischaemic strokes (IS) occur in adults aged <50 years. Of these early-onset strokes, up to 50% can be regarded as cryptogenic or associated with conditions with poorly documented causality like patent foramen ovale and coagulopathies. Key hypotheses/aims: (1) Investigate transient triggers and clinical/sub-clinical chronic risk factors associated with cryptogenic IS in the young; (2) use cardiac imaging methods exceeding state-of-the-art to reveal novel sources for embolism; (3) search for covert thrombosis and haemostasis abnormalities; (4) discover new disease pathways using next-generation sequencing and RNA gene expression studies; (5) determine patient prognosis by use of phenotypic and genetic data; and (6) adapt systems medicine approach to investigate complex risk-factor interactions. Design: Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Etiology, Triggers, and Outcome (SECRETO; NCT01934725) is a prospective multi-centre case–control study enrolling patients aged 18–49 years hospitalised due to first-ever imaging-proven IS of undetermined etiology. Patients are examined according to a standardised protocol and followed up for 10 years. Patients are 1:1 age- and sex-matched to stroke-free controls. Key study elements include centralised reading of echocardiography, electrocardiography, and neurovascular imaging, as well as blood samples for genetic, gene-expression, thrombosis and haemostasis and biomarker analysis. We aim to have 600 patient–control pairs enrolled by the end of 2018. Summary: SECRETO is aiming to establish novel mechanisms and prognosis of cryptogenic IS in the young and will provide new directions for therapy development for these patients. First results are anticipated in 2019.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
653 a Brain infarction
653 a echocardiography
653 a electrocardiography
653 a embolism
653 a middle aged
653 a paradoxical embolism
653 a patent foramen ovale
653 a prognosis
653 a risk factors
653 a stroke
653 a thrombosis
653 a young adult
7001 a Martinez-Majander, Nicolasu Helsinki University Central Hospital4 aut
7001 a Saeed, Sahraiu University of Bergen4 aut
7001 a Yesilot, Niluferu Istanbul University4 aut
7001 a Jäkälä, Pekkau Kuopio University Hospital4 aut
7001 a Nerg, Ossiu Kuopio University Hospital4 aut
7001 a Tsivgoulis, Georgiosu National and Kapodistrian University of Athens,Attikon University Hospital4 aut
7001 a Numminen, Heikkiu Tampere University Hospital4 aut
7001 a Gordin, Danielu Folkhälsan Research Center,University of Helsinki4 aut
7001 a von Sarnowski, Bettinau University of Greifswald4 aut
7001 a Waje-Andreassen, Ulrikeu Haukeland University Hospital4 aut
7001 a Ylikotila, Pauliu Turku University Hospital,University of Turku4 aut
7001 a Roine, Risto O.u Turku University Hospital,University of Turku4 aut
7001 a Zedde, Marialuisau Arcispedale Santa Maria Nuova4 aut
7001 a Huhtakangas, Juhau Oulu University Hospital4 aut
7001 a Fonseca, Catarinau Santa Maria Hospital, Lisbon,University of Lisbon4 aut
7001 a Redfors, Petrau University of Gothenburg,Sahlgrenska University Hospital4 aut
7001 a de Leeuw, Frank Eriku Radboud University Medical Center4 aut
7001 a Pezzini, Alessandrou University of Brescia4 aut
7001 a Kõrv, Janikau University of Tartu4 aut
7001 a Schneider, Siimu North Estonia Medical Centre4 aut
7001 a Tanislav, Christianu Justus Liebig University Giessen4 aut
7001 a Enzinger, Christianu Medical University of Graz4 aut
7001 a Jatuzis, Daliusu Vilnius University4 aut
7001 a Siegerink, Bobu Charité - University Medicine Berlin4 aut
7001 a Martínez-Sánchez, Patriciau Autonomous University of Madrid,University Hospital La Paz4 aut
7001 a Grau, Armin J.u Klinikum Ludwigshafen4 aut
7001 a Palm, Fredericku Klinikum Ludwigshafen4 aut
7001 a Groop, Per Henriku University of Helsinki,Folkhälsan Research Center4 aut
7001 a Lanthier, Sylvainu University Of Montreal Health Center (CRCHUM)4 aut
7001 a Ten Cate, Hugou Maastricht University4 aut
7001 a Pussinen, Pirkkou Helsinki University Central Hospital,University of Helsinki4 aut
7001 a Paju, Susannau Helsinki University Central Hospital,University of Helsinki4 aut
7001 a Sinisalo, Juhau Helsinki University Central Hospital4 aut
7001 a Lehto, Mikau Helsinki University Central Hospital4 aut
7001 a Lindgren, Arneu Lund University,Lunds universitet,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Clinical Stroke Research Group,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)neur-ali
7001 a Ferro, Joséu University of Lisbon,Santa Maria Hospital, Lisbon4 aut
7001 a Kittner, Stevenu Baltimore Veterans Administration Medical Center,University of Maryland4 aut
7001 a Fazekas, Franzu Medical University of Graz4 aut
7001 a Gerdts, Evau University of Bergen4 aut
7001 a Tatlisumak, Turgutu Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Helsinki University Central Hospital,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience4 aut0 (Swepub:gu)xtatlt
7102 a Helsinki University Central Hospitalb University of Bergen4 org
7730 t European Stroke Journald : SAGE Publicationsg 2:2, s. 116-125q 2:2<116-125x 2396-9873x 2396-9881
8564 u http://dx.doi.org/10.1177/2396987317703210y FULLTEXT
8564 u https://journals.sagepub.com/doi/pdf/10.1177/2396987317703210
8564 8u https://lup.lub.lu.se/record/fce74cee-9719-46fa-9df6-ccf15e744f68
8564 8u https://doi.org/10.1177/2396987317703210
8564 8u https://gup.ub.gu.se/publication/266256

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