Radiation Dose of the P-Glycoprotein Tracer 11C-Laniquidar.

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Fältnamn	Indikatorer	Metadata
000		02900naa a2200409 4500
001		oai:DiVA.org:uu-210505
003		SwePub
008		131108s2013 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2105052 URI
024	7	a https://doi.org/10.2967/jnumed.113.1208572 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Postnov, Andrey4 aut
245	1 0	a Radiation Dose of the P-Glycoprotein Tracer 11C-Laniquidar.
264		c 2013-10-03
264	1	b Society of Nuclear Medicine,c 2013
338		a print2 rdacarrier
520		a Resistance to current drug therapy is an important issue in the treatment of epilepsy. Inadequate access of central nervous system drugs to their targets in the brain may be caused by overexpression or overactivity of multidrug transporters, such as P-glycoprotein (P-gp), at the blood-brain barrier. Laniquidar, an inhibitor of P-gp, has been labeled with (11)C for use in PET studies of P-gp expression in humans. Given potential interspecies differences in biodistribution, the purpose of this study was to ensure safe use of (11)C-laniquidar by determining the dosimetry of (11)C-laniquidar using whole-body PET studies.METHODS: Six healthy volunteers were subjected to a series of 10 whole-body PET scans within approximately 70 min. Five blood samples were taken during the series.RESULTS: High uptake of (11)C-laniquidar was seen in liver, spleen, kidneys, and lung, whereas brain uptake was low. The effective dose for (11)C-laniquidar was 4.76 ± 0.13 and 3.69 ± 0.01 μSv·MBq(-1) for women and men, respectively.CONCLUSION: Biodistribution and measured effective dose indicate that (11)C-laniquidar is a safe tracer for PET imaging, with a total dose of about 2 mSv for a brain PET/CT protocol.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
700	1	a Froklage, Femke E4 aut
700	1	a van Lingen, Arthur4 aut
700	1	a Reijneveld, Jaap C4 aut
700	1	a Hendrikse, N Harry4 aut
700	1	a Windhorst, Albert D4 aut
700	1	a Schuit, Robert C4 aut
700	1	a Eriksson, Jonasu VU university medical center Amsterdam4 aut0 (Swepub:uu)joeri542
700	1	a Lammertsma, Adriaan A4 aut
700	1	a Huisman, Marc C4 aut
710	2	a VU university medical center Amsterdam4 org
773	0	t Journal of Nuclear Medicined : Society of Nuclear Medicineg 54:12, s. 2101-2103q 54:12<2101-2103x 0161-5505x 1535-5667x 2159-662X
856	4	u http://jnm.snmjournals.org/content/54/12/2101.full.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-210505
856	4 8	u https://doi.org/10.2967/jnumed.113.120857

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