WFRF:(Hultenby K.)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03006naa a2200349 4500 | |
| 001 | oai:DiVA.org:su-129544 | |
| 003 | SwePub | |
| 008 | 160425s1992 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1295442 URI |
| 040 | a (SwePub)su | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Olsson, U4 aut |
| 245 | 1 0 | a The involvement of selenium in peroxisome proliferation caused by dietary administration of clofibrate to rats. |
| 264 | 1 | c 1992 |
| 338 | a print2 rdacarrier | |
| 520 | a The effects of dietary treatment with clofibrate (0.5% w/w for 10 days) on the livers of selenium-deficient male rats were examined. The peroxisome proliferation (as determined by electron microscopy) in the livers of selenium-deficient animals was much less pronounced than in the case of selenium-adequate rats and no increase in peroxisomal fatty acid beta-oxidation (assayed both as antimycin-insensitive palmitoyl-CoA oxidation and lauroyl-CoA oxidase activity) was observed in the deficient animals. On the other hand, in selenium-deficient rats clofibrate caused increases in the specific activity of microsomal lauric acid omega- and omega-1-hydroxylation and an apparent change in mitochondrial size, seen as a redistribution of mitochondria from the 600 x g(av) pellet to the 10,000 x g(av) pellet, which were approximately 50% as great as the corresponding effects on control animals. Obviously, then, these three different effects of clofibrate are not strictly coupled and may involve at least partially distinct underlying mechanisms. Initial experiments demonstrated that peroxisome proliferation could be obtained by exposing primary hepatocyte cultures derived from selenium-deficient rats to clofibric acid (an in vivo hydrolysis product of clofibrate which is the proximate peroxisome proliferator), nafenopin or mono(2-ethylhexyl)phthalate. This finding suggests that selenium deficiency does not have a direct influence on the basic process(es) underlying peroxisome proliferation, but rather has indirect effects, influencing, for example, the pharmacokinetics of clofibrate and/or hormonal factors. | |
| 650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
| 700 | 1 | a Garberg, P4 aut |
| 700 | 1 | a Lundgren, Bou Stockholms universitet,Institutionen för biokemi och biofysik4 aut |
| 700 | 1 | a Andersson, K4 aut |
| 700 | 1 | a Hultenby, K4 aut |
| 700 | 1 | a Bergstrand, A4 aut |
| 700 | 1 | a Eriksson, A M4 aut |
| 700 | 1 | a Högberg, J4 aut |
| 700 | 1 | a DePierre, J W4 aut |
| 710 | 2 | a Stockholms universitetb Institutionen för biokemi och biofysik4 org |
| 773 | 0 | t Chemico-Biological Interactionsg 85:1q 85:1x 0009-2797x 1872-7786 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-129544 |
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