WFRF:(Hurme Saija)
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Liver blood dynamics after bariatric surgery : The effects of mixed-meal test and incretin infusions
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- Honka, Henri (author)
- University of Turku
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- Koffert, Jukka (author)
- University of Turku,Turku University Hospital
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- Kauhanen, Saila (author)
- Turku University Hospital
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- (creator_code:org_t)
- 2018
- 2018
- English 9 s.
- In: Endocrine Connections. - 2049-3614. ; 7:7, s. 888-896
- Journal article (peer-reviewed)
Abstract
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- Aims/hypothesis: The mechanisms for improved glycemic control after bariatric surgery in subjects with type 2 diabetes (T2D) are not fully known. We hypothesized that dynamic hepatic blood responses to a mixed-meal are changed after bariatric surgery in parallel with an improvement in glucose tolerance. Methods: A total of ten morbidly obese subjects with T2D were recruited to receive a mixed-meal and a glucose-dependent insulinotropic polypeptide (GIP) infusion before and early after (within a median of less than three months) bariatric surgery, and hepatic blood flow and volume (HBV) were measured repeatedly with combined positron emission tomography/MRI. Ten lean non-diabetic individuals served as controls. Results: Bariatric surgery leads to a significant decrease in weight, accompanied with an improved β-cell function and glucagon-like peptide 1 (GLP-1) secretion, and a reduction in liver volume. Blood flow in portal vein (PV) was increased by 1.65-fold (P = 0.026) in response to a mixed-meal in subjects after surgery, while HBV decreased in all groups (P < 0.001). When the effect of GIP infusion was tested separately, no change in hepatic arterial and PV flow was observed, but HBV decreased as seen during the mixed-meal test. Conclusions/interpretation: Early after bariatric surgery, PV flow response to a mixed-meal is augmented, improving digestion and nutrient absorption. GIP influences the post-prandial reduction in HBV thereby diverting blood to the extrahepatic sites.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Bariatric surgery
- Glucose-dependent insulinotropic polypeptide
- Hepatic blood volume
- Portal vein blood flow
- Positron emission tomography
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- art (subject category)
- ref (subject category)
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- Honka, Henri
- Koffert, Jukka
- Kauhanen, Saila
- Kudomi, Nobuyuki
- Hurme, Saija
- Mari, Andrea
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- Wierup, Nils
- Parkkola, Riitta
- Groop, Leif
- Nuutila, Pirjo
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- Lund University
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