SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Idland Ane Victoria)
 

Sökning: WFRF:(Idland Ane Victoria) > Morenas Rodríguez Estrella > GBA and APOE ε4 ass...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006626naa a2200829 4500
001oai:lup.lub.lu.se:63872b5d-9c7d-491a-bbb6-c147d9a4de44
003SwePub
008190522s2019 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:140866819
0247 a https://lup.lub.lu.se/record/63872b5d-9c7d-491a-bbb6-c147d9a4de442 URI
0247 a https://doi.org/10.1038/s41598-019-43458-22 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1408668192 URI
040 a (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Rongve, Arvidu Haugesund Hospital,University of Bergen4 aut
2451 0a GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study
264 c 2019-05-07
264 1b Springer Science and Business Media LLC,c 2019
520 a Dementia with Lewy Bodies (DLB) is a common neurodegenerative disorder with poor prognosis and mainly unknown pathophysiology. Heritability estimates exceed 30% but few genetic risk variants have been identified. Here we investigated common genetic variants associated with DLB in a large European multisite sample. We performed a genome wide association study in Norwegian and European cohorts of 720 DLB cases and 6490 controls and included 19 top-associated single-nucleotide polymorphisms in an additional cohort of 108 DLB cases and 75545 controls from Iceland. Overall the study included 828 DLB cases and 82035 controls. Variants in the ASH1L/GBA (Chr1q22) and APOE ε4 (Chr19) loci were associated with DLB surpassing the genome-wide significance threshold (p < 5 × 10 −8 ). One additional genetic locus previously linked to psychosis in Alzheimer’s disease, ZFPM1 (Chr16q24.2), showed suggestive association with DLB at p-value < 1 × 10 −6 . We report two susceptibility loci for DLB at genome-wide significance, providing insight into etiological factors. These findings highlight the complex relationship between the genetic architecture of DLB and other neurodegenerative disorders.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
7001 a Witoelar, Areeu Oslo university hospital,University of Oslo4 aut
7001 a Ruiz, Agustínu International University of Catalonia4 aut
7001 a Athanasiu, Laviniau Oslo university hospital,University of Oslo4 aut
7001 a Abdelnour, Carlau International University of Catalonia4 aut
7001 a Clarimon, Jordiu CIBER Enfermedades Neurodegenerativas (CIBERNED),Autonomous University of Barcelona4 aut
7001 a Heilmann-Heimbach, Stefanieu University of Bonn4 aut
7001 a Hernández, Isabelu International University of Catalonia4 aut
7001 a Moreno-Grau, Soniau International University of Catalonia4 aut
7001 a de Rojas, Itziaru International University of Catalonia4 aut
7001 a Morenas-Rodríguez, Estrellau Autonomous University of Barcelona,CIBER Enfermedades Neurodegenerativas (CIBERNED)4 aut
7001 a Fladby, Tormodu Akershus University Hospital,University of Oslo4 aut
7001 a Sando, Sigrid B.u Norwegian University of Science and Technology4 aut
7001 a Bråthen, Geiru St. Olav’s University Hospital4 aut
7001 a Blanc, Frédéricu University Hospital Of Strasbourg,University of Strasbourg4 aut
7001 a Bousiges, Olivieru University Hospital Of Strasbourg4 aut
7001 a Lemstra, Afina W.u University of Strasbourg,Amsterdam UMC - Vrije Universiteit Amsterdam4 aut
7001 a van Steenoven, Ingeru University of Strasbourg,Amsterdam UMC - Vrije Universiteit Amsterdam4 aut
7001 a Londos, Elisabetu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)pski-elo
7001 a Almdahl, Ina S.u University of Oslo,Oslo university hospital4 aut
7001 a Pålhaugen, Leneu Akershus University Hospital,University of Oslo4 aut
7001 a Eriksen, Jon A.u University of Oslo,Oslo university hospital4 aut
7001 a Djurovic, Srdjanu University of Bergen,Oslo university hospital4 aut
7001 a Stordal, Eysteinu Namsos Hospital,Norwegian University of Science and Technology4 aut
7001 a Saltvedt, Ingvildu St. Olav’s University Hospital,Norwegian University of Science and Technology4 aut
7001 a Ulstein, Ingun D.u Oslo university hospital,University of Oslo4 aut
7001 a Bettella, Francescou Oslo university hospital4 aut
7001 a Desikan, Rahul S.u University of California, San Francisco4 aut
7001 a Idland, Ane Victoriau University of Oslo4 aut
7001 a Toft, Mathiasu University of Oslo,Oslo university hospital4 aut
7001 a Pihlstrøm, Lasseu Oslo university hospital4 aut
7001 a Snaedal, Jonu National University Hospital of Iceland4 aut
7001 a Tárraga, Lluísu International University of Catalonia4 aut
7001 a Boada, Mercèu International University of Catalonia4 aut
7001 a Lleó, Albertou CIBER Enfermedades Neurodegenerativas (CIBERNED),Autonomous University of Barcelona4 aut
7001 a Stefánsson, Hreinnu deCODE Genetics4 aut
7001 a Stefánsson, Káriu deCODE Genetics4 aut
7001 a Ramírez, Alfredou University of Cologne,University of Bonn4 aut
7001 a Aarsland, Dagu Karolinska Institutet,King's College London,Stavanger University Hospital4 aut
7001 a Andreassen, Ole A.u University of Oslo,Oslo university hospital4 aut
7102 a Haugesund Hospitalb University of Bergen4 org
7730 t Scientific Reportsd : Springer Science and Business Media LLCg 9:1q 9:1x 2045-2322
8564 u http://dx.doi.org/10.1038/s41598-019-43458-2x freey FULLTEXT
8564 u https://www.nature.com/articles/s41598-019-43458-2.pdf
8564 8u https://lup.lub.lu.se/record/63872b5d-9c7d-491a-bbb6-c147d9a4de44
8564 8u https://doi.org/10.1038/s41598-019-43458-2
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:140866819

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy