Sökning: WFRF:(Isaac L) > (2008-2009) > Genome-wide associa...
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000 | 10575naa a2202317 4500 | |
001 | oai:lup.lub.lu.se:9c29cb8d-579b-41f9-9ca3-4b39d24519a7 | |
003 | SwePub | |
008 | 160401s2009 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:118831963 | |
009 | oai:DiVA.org:uu-129032 | |
024 | 7 | a https://lup.lub.lu.se/record/14248192 URI |
024 | 7 | a https://doi.org/10.1038/ng.3612 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1188319632 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1290322 URI |
040 | a (SwePub)lud (SwePub)kid (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Newton-Cheh, Christopher4 aut |
245 | 1 0 | a Genome-wide association study identifies eight loci associated with blood pressure |
264 | c 2009-05-10 | |
264 | 1 | b Springer Science and Business Media LLC,c 2009 |
520 | a Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N <= 71,225 European ancestry, N <= 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 x 10(-24)), CYP1A2 (P = 1 x 10(-23)), FGF5 (P = 1 x 10(-21)), SH2B3 (P = 3 x 10(-18)), MTHFR (P = 2 x 10(-13)), c10orf107 (P = 1 x 10(-9)), ZNF652 (P = 5 x 10(-9)) and PLCD3 (P = 1 x 10(-8)) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Annan klinisk medicin0 (SwePub)302992 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Other Clinical Medicine0 (SwePub)302992 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
653 | a MEDICINE | |
700 | 1 | a Johnson, Toby4 aut |
700 | 1 | a Gateva, Vesela4 aut |
700 | 1 | a Tobin, Martin D.4 aut |
700 | 1 | a Bochud, Murielle4 aut |
700 | 1 | a Coin, Lachlan4 aut |
700 | 1 | a Najjar, Samer S.4 aut |
700 | 1 | a Zhao, Jing Hua4 aut |
700 | 1 | a Heath, Simon C.4 aut |
700 | 1 | a Eyheramendy, Susana4 aut |
700 | 1 | a Papadakis, Konstantinos4 aut |
700 | 1 | a Voight, Benjamin F.4 aut |
700 | 1 | a Scott, Laura J.4 aut |
700 | 1 | a Zhang, Feng4 aut |
700 | 1 | a Farrall, Martin4 aut |
700 | 1 | a Tanaka, Toshiko4 aut |
700 | 1 | a Wallace, Chris4 aut |
700 | 1 | a Chambers, John C.4 aut |
700 | 1 | a Khaw, Kay-Tee4 aut |
700 | 1 | a Nilsson, Peteru Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-pni |
700 | 1 | a van der Harst, Pim4 aut |
700 | 1 | a Polidoro, Silvia4 aut |
700 | 1 | a Grobbee, Diederick E.4 aut |
700 | 1 | a Onland-Moret, N. Charlotte4 aut |
700 | 1 | a Bots, Michiel L.4 aut |
700 | 1 | a Wain, Louise V.4 aut |
700 | 1 | a Elliott, Katherine S.4 aut |
700 | 1 | a Teumer, Alexander4 aut |
700 | 1 | a Luan, Jian'an4 aut |
700 | 1 | a Lucas, Gavin4 aut |
700 | 1 | a Kuusisto, Johanna4 aut |
700 | 1 | a Burton, Paul R.4 aut |
700 | 1 | a Hadley, David4 aut |
700 | 1 | a McArdle, Wendy L.4 aut |
700 | 1 | a Brown, Morris4 aut |
700 | 1 | a Dominiczak, Anna4 aut |
700 | 1 | a Newhouse, Stephen J.4 aut |
700 | 1 | a Samani, Nilesh J.4 aut |
700 | 1 | a Webster, John4 aut |
700 | 1 | a Zeggini, Eleftheria4 aut |
700 | 1 | a Beckmann, Jacques S.4 aut |
700 | 1 | a Bergmann, Sven4 aut |
700 | 1 | a Lim, Noha4 aut |
700 | 1 | a Song, Kijoung4 aut |
700 | 1 | a Vollenweider, Peter4 aut |
700 | 1 | a Waeber, Gerard4 aut |
700 | 1 | a Waterworth, Dawn M.4 aut |
700 | 1 | a Yuan, Xin4 aut |
700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr |
700 | 1 | a Orho-Melander, Marjuu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-mor |
700 | 1 | a Allione, Alessandrau Karolinska Institutet4 aut |
700 | 1 | a Di Gregorio, Alessandra4 aut |
700 | 1 | a Guarrera, Simonetta4 aut |
700 | 1 | a Panico, Salvatore4 aut |
700 | 1 | a Ricceri, Fulvio4 aut |
700 | 1 | a Romanazzi, Valeria4 aut |
700 | 1 | a Sacerdote, Carlotta4 aut |
700 | 1 | a Vineis, Paolo4 aut |
700 | 1 | a Barroso, Ines4 aut |
700 | 1 | a Sandhu, Manjinder S.4 aut |
700 | 1 | a Luben, Robert N.4 aut |
700 | 1 | a Crawford, Gabriel J.4 aut |
700 | 1 | a Jousilahti, Pekka4 aut |
700 | 1 | a Perola, Markus4 aut |
700 | 1 | a Boehnke, Michael4 aut |
700 | 1 | a Bonnycastle, Lori L.4 aut |
700 | 1 | a Collins, Francis S.4 aut |
700 | 1 | a Jackson, Anne U.4 aut |
700 | 1 | a Mohlke, Karen L.4 aut |
700 | 1 | a Stringham, Heather M.4 aut |
700 | 1 | a Valle, Timo T.4 aut |
700 | 1 | a Willer, Cristen J.4 aut |
700 | 1 | a Bergman, Richard N.4 aut |
700 | 1 | a Morken, Mario A.4 aut |
700 | 1 | a Doering, Angela4 aut |
700 | 1 | a Gieger, Christian4 aut |
700 | 1 | a Illig, Thomas4 aut |
700 | 1 | a Meitinger, Thomas4 aut |
700 | 1 | a Org, Elin4 aut |
700 | 1 | a Pfeufer, Arne4 aut |
700 | 1 | a Wichmann, H. Erich4 aut |
700 | 1 | a Kathiresan, Sekar4 aut |
700 | 1 | a Marrugat, Jaume4 aut |
700 | 1 | a O'Donnell, Christopher J.4 aut |
700 | 1 | a Schwartz, Stephen M.4 aut |
700 | 1 | a Siscovick, David S.4 aut |
700 | 1 | a Subirana, Isaac4 aut |
700 | 1 | a Freimer, Nelson B.4 aut |
700 | 1 | a Hartikainen, Anna-Liisa4 aut |
700 | 1 | a McCarthy, Mark I.4 aut |
700 | 1 | a O'Reilly, Paul F.4 aut |
700 | 1 | a Peltonen, Leena4 aut |
700 | 1 | a Pouta, Anneli4 aut |
700 | 1 | a de Jong, Paul E.4 aut |
700 | 1 | a Snieder, Harold4 aut |
700 | 1 | a van Gilst, Wiek H.4 aut |
700 | 1 | a Clarke, Robert4 aut |
700 | 1 | a Goel, Anuj4 aut |
700 | 1 | a Hamsten, Anders4 aut |
700 | 1 | a Peden, John F.4 aut |
700 | 1 | a Seedorf, Udo4 aut |
700 | 1 | a Syvänen, Ann-Christineu Uppsala universitet,Molekylär medicin4 aut0 (Swepub:uu)anncsyva |
700 | 1 | a Tognoni, Giovanni4 aut |
700 | 1 | a Lakatta, Edward G.4 aut |
700 | 1 | a Sanna, Serena4 aut |
700 | 1 | a Scheet, Paul4 aut |
700 | 1 | a Schlessinger, David4 aut |
700 | 1 | a Scuteri, Angelo4 aut |
700 | 1 | a Doerr, Marcus4 aut |
700 | 1 | a Ernst, Florian4 aut |
700 | 1 | a Felix, Stephan B.4 aut |
700 | 1 | a Homuth, Georg4 aut |
700 | 1 | a Lorbeer, Roberto4 aut |
700 | 1 | a Reffelmann, Thorsten4 aut |
700 | 1 | a Rettig, Rainer4 aut |
700 | 1 | a Voelker, Uwe4 aut |
700 | 1 | a Galan, Pilar4 aut |
700 | 1 | a Gut, Ivo G.4 aut |
700 | 1 | a Hercberg, Serge4 aut |
700 | 1 | a Lathrop, G. Mark4 aut |
700 | 1 | a Zelenika, Diana4 aut |
700 | 1 | a Deloukas, Panos4 aut |
700 | 1 | a Soranzo, Nicole4 aut |
700 | 1 | a Williams, Frances M.4 aut |
700 | 1 | a Zhai, Guangju4 aut |
700 | 1 | a Salomaa, Veikko4 aut |
700 | 1 | a Laakso, Markku4 aut |
700 | 1 | a Elosua, Roberto4 aut |
700 | 1 | a Forouhi, Nita G.4 aut |
700 | 1 | a Volzke, Henry4 aut |
700 | 1 | a Uiterwaal, Cuno S.4 aut |
700 | 1 | a van der Schouw, Yvonne T.4 aut |
700 | 1 | a Numans, Mattijs E.4 aut |
700 | 1 | a Matullo, Giuseppe4 aut |
700 | 1 | a Navis, Gerjan4 aut |
700 | 1 | a Berglund, Göranu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-gbe |
700 | 1 | a Bingham, Sheila A.4 aut |
700 | 1 | a Kooner, Jaspal S.4 aut |
700 | 1 | a Connell, John M.4 aut |
700 | 1 | a Bandinelli, Stefania4 aut |
700 | 1 | a Ferrucci, Luigi4 aut |
700 | 1 | a Watkins, Hugh4 aut |
700 | 1 | a Spector, Tim D.4 aut |
700 | 1 | a Tuomilehto, Jaakko4 aut |
700 | 1 | a Altshuler, David4 aut |
700 | 1 | a Strachan, David P.4 aut |
700 | 1 | a Laan, Maris4 aut |
700 | 1 | a Meneton, Pierre4 aut |
700 | 1 | a Wareham, Nicholas J.4 aut |
700 | 1 | a Uda, Manuela4 aut |
700 | 1 | a Jarvelin, Marjo-Riitta4 aut |
700 | 1 | a Mooser, Vincent4 aut |
700 | 1 | a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome |
700 | 1 | a Loos, Ruth J. F.4 aut |
700 | 1 | a Elliott, Paul4 aut |
700 | 1 | a Abecasis, Goncalo R.4 aut |
700 | 1 | a Caulfield, Mark4 aut |
700 | 1 | a Munroe, Patricia B.4 aut |
710 | 2 | a Internmedicin - epidemiologib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Nature Geneticsd : Springer Science and Business Media LLCg 41:6, s. 666-676q 41:6<666-676x 1546-1718x 1061-4036 |
856 | 4 | u http://dx.doi.org/10.1038/ng.361y FULLTEXT |
856 | 4 | u https://www.pure.ed.ac.uk/ws/files/8320684/Genome_wide_association_study_identifies_eight_loci_associated_with_blood_pressure.pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/1424819 |
856 | 4 8 | u https://doi.org/10.1038/ng.361 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:118831963 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-129032 |
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