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WFRF:(Itoh Hiroshi)
 

Sökning: WFRF:(Itoh Hiroshi) > (2006-2009) > CD47 promotes neuro...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003459naa a2200541 4500
001oai:DiVA.org:umu-12289
003SwePub
008080111s2006 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-122892 URI
0247 a https://doi.org/10.1523/JNEUROSCI.3981-06.20062 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Murata, Takaaki4 aut
2451 0a CD47 promotes neuronal development through Src- and FRG/Vav2-mediated activation of Rac and Cdc42.
264 1c 2006
338 a print2 rdacarrier
520 a The development of axons and dendrites is controlled by small GTP-binding proteins of the Rho family, but the upstream signaling mechanisms responsible for such regulation remain unclear. We have now investigated the role of the transmembrane protein cluster of differentiation 47 (CD47) in this process with hippocampal neurons. CD47-deficient neurons manifested markedly impaired development of dendrites and axons, whereas overexpression of CD47 promoted such development. Interaction of SH2 domain-containing protein tyrosine phosphatase substrate-1 (SHPS-1) with CD47 also induced the formation of dendritic filopodia and spines. These effects of CD47 were prevented by inhibition of either cell division cycle 42 (Cdc42) or Rac. In CD47-deficient neurons, autophosphorylation of Src was markedly reduced. In addition, overexpression of CD47 promoted the autophosphorylation of Src. Inhibition of Src family kinases indeed prevented CD47-promoted dendritic development. Inhibition of either FGD1-related Cdc42-guanine nucleotide exchange factor (GEF) (FRG) or Vav2, which is a GEF for Cdc42 and Rac and is activated by Src, also prevented the effects of CD47 on dendritic development. These results indicate that CD47 promotes development of dendrites and axons in hippocampal neurons in a manner dependent, at least in part, on activation of Cdc42 and Rac mediated by Src as well as by FRG and Vav2.
653 a Animals
653 a Antigens; CD47/*metabolism
653 a Cells; Cultured
653 a Hippocampus/growth & development/metabolism
653 a Humans
653 a Mice
653 a Mice; Knockout
653 a Neurons/*cytology/*metabolism/physiology
653 a Proteins/*physiology
653 a Proto-Oncogene Proteins c-vav/*physiology
653 a cdc42 GTP-Binding Protein/*metabolism
653 a rac GTP-Binding Proteins/*metabolism
653 a src-Family Kinases/*physiology
7001 a Ohnishi, Hiroshi4 aut
7001 a Okazawa, Hideki4 aut
7001 a Murata, Yoji4 aut
7001 a Kusakari, Shinya4 aut
7001 a Hayashi, Yuriko4 aut
7001 a Miyashita, Motoaki4 aut
7001 a Itoh, Hiroshi4 aut
7001 a Oldenborg, Per-Arneu Umeå universitet,Histologi med cellbiologi4 aut0 (Swepub:umu)peol0001
7001 a Furuya, Nobuhiko4 aut
7001 a Matozaki, Takashi4 aut
7102 a Umeå universitetb Histologi med cellbiologi4 org
7730 t Journal of Neuroscienceg 26:48, s. 12397-407q 26:48<12397-407x 1529-2401
8564 u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17135401&dopt=Citation
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-12289
8564 8u https://doi.org/10.1523/JNEUROSCI.3981-06.2006

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