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A Combination of N ...
A Combination of N and S Antigens With IgA and IgG Measurement Strengthens the Accuracy of SARS-CoV-2 Serodiagnostics
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- Jalkanen, Pinja (författare)
- Univ Turku, Inst Biomed, Infect & Immunol Unit, Turku, Finland.
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- Pasternack, Arja (författare)
- Univ Helsinki, Dept Physiol, Biomed, Helsinki, Finland.
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- Maljanen, Sari (författare)
- Univ Turku, Inst Biomed, Infect & Immunol Unit, Turku, Finland.
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- Melen, Krister (författare)
- Univ Turku, Inst Biomed, Infect & Immunol Unit, Turku, Finland.;Finnish Inst Hlth & Welf, Helsinki, Finland.
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- Kolehmainen, Pekka (författare)
- Univ Turku, Inst Biomed, Infect & Immunol Unit, Turku, Finland.
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- Huttunen, Moona (författare)
- Univ Turku, Inst Biomed, Infect & Immunol Unit, Turku, Finland.
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- Lundberg, Rickard (författare)
- Univ Turku, Inst Biomed, Infect & Immunol Unit, Turku, Finland.
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- Tripathi, Lav (författare)
- Univ Turku, Inst Biomed, Infect & Immunol Unit, Turku, Finland.
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- Khan, Hira (författare)
- Univ Turku, Inst Biomed, Infect & Immunol Unit, Turku, Finland.
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- Ritvos, Mikael A. (författare)
- KTH,Skolan för kemi, bioteknologi och hälsa (CBH),Univ Helsinki, Dept Physiol, Biomed, Helsinki, Finland. Nordic SARS Response AB, Stockholm, Sweden.
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- Naves, Rauno (författare)
- Univ Helsinki, Dept Physiol, Biomed, Helsinki, Finland.
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- Haveri, Anu (författare)
- Finnish Inst Hlth & Welf, Helsinki, Finland.
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- Osterlund, Pamela (författare)
- Finnish Inst Hlth & Welf, Helsinki, Finland.
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- Kuivanen, Suvi (författare)
- Univ Helsinki, Dept Virol, Helsinki, Finland.
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- Jaaskelainen, Anne J. (författare)
- Univ Helsinki, HUS Diagnost Ctr, HUSLAB, Clin Microbiol, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.
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- Kurkela, Satu (författare)
- Univ Helsinki, HUS Diagnost Ctr, HUSLAB, Clin Microbiol, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.
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- Lappalainen, Maija (författare)
- Univ Helsinki, HUS Diagnost Ctr, HUSLAB, Clin Microbiol, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.
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- Rantasarkka, Kaisa (författare)
- Turku Univ Hosp, Clin Microbiol, Turku, Finland.
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- Vuorinen, Tytti (författare)
- Univ Turku, Inst Biomed, Infect & Immunol Unit, Turku, Finland.;Turku Univ Hosp, Clin Microbiol, Turku, Finland.
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- Hytonen, Jukka (författare)
- Univ Turku, Inst Biomed, Infect & Immunol Unit, Turku, Finland.;Turku Univ Hosp, Clin Microbiol, Turku, Finland.
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- Waris, Matti (författare)
- Univ Turku, Inst Biomed, Infect & Immunol Unit, Turku, Finland.;Turku Univ Hosp, Clin Microbiol, Turku, Finland.
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- Tauriainen, Sisko (författare)
- Univ Turku, Inst Biomed, Infect & Immunol Unit, Turku, Finland.
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- Ritvos, Olli (författare)
- Univ Helsinki, Dept Physiol, Biomed, Helsinki, Finland.
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- Kakkola, Laura (författare)
- Univ Turku, Inst Biomed, Infect & Immunol Unit, Turku, Finland.
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- Julkunen, Ilkka (författare)
- Univ Turku, Inst Biomed, Infect & Immunol Unit, Turku, Finland.;Turku Univ Hosp, Clin Microbiol, Turku, Finland.
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Univ Turku, Inst Biomed, Infect & Immunol Unit, Turku, Finland Univ Helsinki, Dept Physiol, Biomed, Helsinki, Finland. (creator_code:org_t)
- 2021-04-27
- 2021
- Engelska.
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Ingår i: Journal of Infectious Diseases. - : Oxford University Press. - 0022-1899 .- 1537-6613. ; 224:2, s. 218-228
- Relaterad länk:
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https://doi.org/10.1...
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background. Primary diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is based on detection of virus RNA in nasopharyngeal swab samples. In addition, analysis of humoral immunity against SARS-CoV-2 has an important role in viral diagnostics and seroprevalence estimates. Methods. We developed and optimized an enzyme immunoassays (EIA) using SARS-CoV-2 nucleoprotein (N), Si and receptor binding domain (RBD) of the viral spike protein, and N proteins from SARS, Middle East respiratory syndrome (MERS), and 4 low-pathogenic human CoVs. Neutralizing antibody activity was compared with SARS-CoV-2 IgG, IgA, and IgM EIA results. Results. The sensitivity of EIA for detecting immune response in COVID-19 patients (n = 101) was 77% in the acute phase and 100% in the convalescent phase of SARS-CoV-2 infection when N and RBD were used as antigens in IgG and IgA specific EIAs. SARS-CoV-2 infection significantly increased humoral immune responses against the 229E and NL63 N proteins. Si and RBD-based EIA results had a strong correlation with microneutralization test results. Conclusions. The data indicate a combination of SARS-CoV-2 Si or RBD and N proteins and analysis of IgG and IgA immunoglobulin classes in sera provide an excellent basis for specific and sensitive serological diagnostics of COVID-19.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- COVID-19
- SARS-CoV-2
- enzyme immunoassay
- serology
- respiratory infection
- antibodies
- coronavirus proteins
- neutralizing antibodies
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- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Jalkanen, Pinja
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Pasternack, Arja
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Maljanen, Sari
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Melen, Krister
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Kolehmainen, Pek ...
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Huttunen, Moona
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visa fler...
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Lundberg, Rickar ...
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Tripathi, Lav
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Khan, Hira
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Ritvos, Mikael A ...
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Naves, Rauno
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Haveri, Anu
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Osterlund, Pamel ...
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Kuivanen, Suvi
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Jaaskelainen, An ...
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Kurkela, Satu
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Lappalainen, Mai ...
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Rantasarkka, Kai ...
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Vuorinen, Tytti
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Hytonen, Jukka
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Waris, Matti
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Tauriainen, Sisk ...
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Ritvos, Olli
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Kakkola, Laura
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Julkunen, Ilkka
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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Journal of Infec ...
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