Sökning: WFRF:(Jerusalem Guy) > Barberis Massimo > Genomic aberrations...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04357naa a2200649 4500 | |
001 | oai:gup.ub.gu.se/297407 | |
003 | SwePub | |
008 | 240910s2021 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/2974072 URI |
024 | 7 | a https://doi.org/10.1158/1078-0432.CCR-20-01262 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Guerini-Rocco, Elena4 aut |
245 | 1 0 | a Genomic aberrations and late recurrence in postmenopausal women with hormone receptor-positive early breast cancer: Results from the SOLE Trial. |
264 | 1 | c 2021 |
520 | a Women with hormone-receptor-positive early breast cancers have a persistent risk of relapse and biomarkers for late recurrence are needed. We sought to identify tumor genomic aberrations associated with increased late recurrence risk.In a secondary analysis of Study of Letrozole Extension (SOLE) trial, a case-cohort-like sampling selected 598 primary breast cancer for targeted next-generation sequencing (NGS) analysis of gene mutations and copy number gains (CNG). Correlations of genomic aberrations with clinicopathologic factors and breast and distant recurrence free-intervals (BCFI and DRFI) were analyzed using weighted Cox models.Analysis of mutations and CNG was successfully performed for 403 and 350 samples, including 148 and 134 patients with breast cancer recurrences (median follow-up time: 5.2 years), respectively. The most frequent alterations were PIK3CA mutations (42%) and CNGs of CCND1 (15%), ERBB2 (10%), FGFR1 (8%) and MYC (8%). PIK3CA mutations and MYC CNG were associated with lower (p=0.03) and higher (p=0.004) tumor grade respectively; a higher Ki67 was seen in tumor with CCND1, ERBB2 and MYC CNGs (p=0.01, <0.001 and 0.03 respectively). FGFR1 CNG was associated with an increased risk of late events in univariate analyses (17/29 patients; BCFI: HR=3.2, 95%CI: 1.48-6.92, p =0.003; DRFI: HR=3.5, 95%CI: 1.61-7.75, p=0.002) and in multivariable models adjusted for clinicopathologic factors.Postmenopausal women with hormone receptor-positive early breast cancer harboring FGFR1 CNG had an increased risk of late recurrence despite extended therapy. FGFR1 CNG may represent a useful prognostic biomarker for late recurrence and a therapeutic target. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a Gray, Kathryn P4 aut |
700 | 1 | a Fumagalli, Caterina4 aut |
700 | 1 | a Reforgiato, Marta Rita4 aut |
700 | 1 | a Leone, Isabella4 aut |
700 | 1 | a Rafaniello Raviele, Paola4 aut |
700 | 1 | a Munzone, Elisabetta4 aut |
700 | 1 | a Kammler, Roswitha4 aut |
700 | 1 | a Neven, Patrick4 aut |
700 | 1 | a Hitre, Erika4 aut |
700 | 1 | a Jerusalem, Guy4 aut |
700 | 1 | a Simoncini, Edda L4 aut |
700 | 1 | a Gombos, Andrea4 aut |
700 | 1 | a Deleu, Ines4 aut |
700 | 1 | a Karlsson, Per,d 1963u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology4 aut0 (Swepub:gu)xkperd |
700 | 1 | a Aebi, Stefan4 aut |
700 | 1 | a Chirgwin, Jacquie4 aut |
700 | 1 | a Di Lauro, Vincenzo4 aut |
700 | 1 | a Thompson, Alastair M4 aut |
700 | 1 | a Graas, Marie-Pascale4 aut |
700 | 1 | a Barber, Matthew4 aut |
700 | 1 | a Fontaine, Christel4 aut |
700 | 1 | a Loibl, Sibylle4 aut |
700 | 1 | a Gavilá, Joaquín4 aut |
700 | 1 | a Kuroi, Katsumasa4 aut |
700 | 1 | a Müller, Bettina4 aut |
700 | 1 | a O'Reilly, Seamus4 aut |
700 | 1 | a Di Leo, Angelo4 aut |
700 | 1 | a Goldhirsch, Aron4 aut |
700 | 1 | a Viale, Giuseppe4 aut |
700 | 1 | a Barberis, Massimo4 aut |
700 | 1 | a Regan, Meredith M4 aut |
700 | 1 | a Colleoni, Marco4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för onkologi4 org |
773 | 0 | t Clinical cancer research : an official journal of the American Association for Cancer Researchg 27:2, s. 504-512q 27:2<504-512x 1078-0432 |
856 | 4 8 | u https://gup.ub.gu.se/publication/297407 |
856 | 4 8 | u https://doi.org/10.1158/1078-0432.CCR-20-0126 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy