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- Cai, DeminNanjing Agr Univ, Key Lab Anim Physiol & Biochem, Nanjing 210095, Jiangsu, Peoples R China. (författare)
Gestational dietary betaine supplementation suppresses hepatic expression of lipogenic genes in neonatal piglets through epigenetic and glucocorticoid receptor-dependent mechanisms
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
- Elsevier BV,2016
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:uu-274270
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-274270URI
- https://doi.org/10.1016/j.bbalip.2015.10.002DOI
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- Språk:engelska
- Sammanfattning på:engelska
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- Methyl donors play critical roles in nutritional programming through epigenetic regulation of gene expression. Here we fed gestational sows with control or betaine-supplemented diets (3 g/kg) throughout the pregnancy to explore the effects of maternal methyl-donor nutrient on neonatal expression of hepatic lipogenic genes. Betaine-exposed piglets demonstrated significantly lower liver triglyceride content associated with down-regulated hepatic expression of lipogenic genes acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), stearoyl-CoA desaturase (SCD) and sterol regulatory element-binding protein-1c. Moreover, s-adenosyl methionine to s-adenosyl homocysteine ratio was elevated in the liver of betaine-exposed piglets, which was accompanied by DNA hypermethylation on FAS and SCD gene promoters and more enriched repression histone mark H31K27me3 on SCD gene promoter. Furthermore, glucocorticoid receptor (GR) binding to SCD gene promoter was diminished along with reduced serum cortisol and liver GR protein content in betaine-exposed piglets. GR-mediated SCD gene regulation was confirmed in HepG2 cells in vitro. Dexamethasone (Dex) drastically increased the luciferase activity of porcine SCD promoter, while the deletion of GR response element on SCD promoter significantly attenuated Dex-mediated SCD transactivation. In addition, miR-let-7e, miR-1285 and miR-124a, which respectively target porcine SCD, ACC and GR, were significantly up-regulated in the liver of betaine-exposed piglets, being in accordance with decreased protein content of these three genes. Taken together, our results suggest that maternal dietary betaine supplementation during gestation attenuates hepatic lipogenesis in neonatal piglets via epigenetic and GR-mediated mechanisms.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Medicinsk bioteknologi Medicinsk bioteknologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Medical Biotechnology Medical Biotechnology hsv//eng
- Betaine
- Epigenetic
- GR
- Lipogenesis
- DNA methylation
- Micro-RNAs
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Wang, JunjianUniv Calif Davis, Dept Biochem & Mol Med, Sacramento, CA 95817 USA. (författare)
- Jia, YiminNanjing Agr Univ, Key Lab Anim Physiol & Biochem, Nanjing 210095, Jiangsu, Peoples R China. (författare)
- Liu, HaoyuUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)haoli973 (författare)
- Yuan, MengjieNanjing Agr Univ, Key Lab Anim Physiol & Biochem, Nanjing 210095, Jiangsu, Peoples R China. (författare)
- Dong, HaiboNanjing Agr Univ, Key Lab Anim Physiol & Biochem, Nanjing 210095, Jiangsu, Peoples R China. (författare)
- Zhao, RuqianNanjing Agr Univ, Key Lab Anim Physiol & Biochem, Nanjing 210095, Jiangsu, Peoples R China. (författare)
- Nanjing Agr Univ, Key Lab Anim Physiol & Biochem, Nanjing 210095, Jiangsu, Peoples R China.Univ Calif Davis, Dept Biochem & Mol Med, Sacramento, CA 95817 USA. (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids: Elsevier BV1861:1, s. 41-501388-19811879-2618
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- Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids (Sök värdpublikationen i LIBRIS)
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