Does minimal central nervous system involvement in childhood acute lymphoblastic leukemia increase the risk for central nervous system toxicity?

Harila-Saari, Arja (author): Uppsala universitet,Barnonkologisk och neurologisk forskning

Als-Nielsen, Bodil (author): Univ Hosp, Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.

Johannsdottir, Inga Maria (author): Oslo Univ Hosp, Dept Pediat Hematol Oncol, Oslo, Norway.

Marquart, Hanne Vibeke (author): Univ Copenhagen, Rigshosp, Dept Clin Immunol, Copenhagen, Denmark.

Niinimäki, Riitta (author): Oulu Univ Hosp, Dept Children & Adolescents, Oulu, Finland.;Univ Oulu, PEDEGO Res Unit, Oulu, Finland.

Pronk, Cornelis Jan (author): Skane Univ Hosp, Childhood Canc Ctr, Lund, Sweden.

Schmiegelow, Kjeld (author): Univ Hosp, Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.;Univ Copenhagen, Fac Med, Inst Clin Med, Copenhagen, Denmark.

Vaitkeviciene, Goda (author): Vilnius Univ, Hosp Santaros Klin, Childrens Hosp, Vilnius, Lithuania.

Thastrup, Maria (author): Univ Hosp, Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.

(creator_code:org_t)

2022-04-30
2022
English.
In: Pediatric Blood & Cancer. - : John Wiley & Sons. - 1545-5009 .- 1545-5017. ; 69:7

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Abstract Subject headings

Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) implicates enhanced intrathecal chemotherapy, which is related to CNS toxicity. Whether CNS involvement alone contributes to CNS toxicity remains unclear. We studied the occurrence of all CNS toxicities, seizures, and posterior reversible encephalopathy syndrome (PRES) in children with ALL without enhanced intrathecal chemotherapy with CNS involvement (n = 64) or without CNS involvement (n = 256) by flow cytometry. CNS involvement increased the risk for all CNS toxicities, seizures, and PRES in univariate analysis and, after adjusting for induction therapy, for seizures (hazard ratio [HR] = 3.33; 95% confidence interval [CI]: 1.26-8.82; p = 0.016) and PRES (HR = 4.85; 95% CI: 1.71-13.75; p = 0.003).

By the author/editor: Anastasopoulou, ...; Harila-Saari, Ar ...; Als-Nielsen, Bod ...; Eriksson, Mats A ...; Heyman, Mats; Johannsdottir, I ...; show more...; Marquart, Hanne ...; Niinimäki, Riitt ...; Pronk, Cornelis ...; Schmiegelow, Kje ...; Vaitkeviciene, G ...; Thastrup, Maria; Ranta, Susanna; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Hematology

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