WFRF:(Johansson Malin E V 1971)
Search: WFRF:(Johansson Malin E V 1971) > Potential roles of ...
- 1 of 92
- Previous record
- Next record
- To hitlist
Potential roles of gut microbiome and metabolites in modulating ALS in mice
- Blacher, E. (author)
- Bashiardes, S. (author)
- Shapiro, H. (author)
- show more...
- Rothschild, D. (author)
- Mor, U. (author)
- Dori-Bachash, M. (author)
- Kleimeyer, C. (author)
- Moresi, C. (author)
- Harnik, Y. (author)
- Zur, M. (author)
- Zabari, M. (author)
- Brik, R. B. Z. (author)
- Kviatcovsky, D. (author)
- Zmora, N. (author)
- Cohen, Y. (author)
- Bar, N. (author)
- Levi, I. (author)
- Amar, N. (author)
- Mehlman, T. (author)
- Brandis, A. (author)
- Biton, I. (author)
- Kuperman, Y. (author)
- Tsoory, M. (author)
- Alfahel, L. (author)
- Harmelin, A. (author)
- Schwartz, M. (author)
- Israelson, A. (author)
- Gotkine, M. (author)
- Segal, E. (author)
- Elinav, E. (author)
- show less...
- (creator_code:org_t)
- 2019-07-22
- 2019
- English.
- In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 572:7770
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disorder, in which the clinical manifestations may be influenced by genetic and unknown environmental factors. Here we show that ALS-prone Sod1 transgenic (Sod1-Tg) mice have a pre-symptomatic, vivarium-dependent dysbiosis and altered metabolite configuration, coupled with an exacerbated disease under germ-free conditions or after treatment with broad-spectrum antibiotics. We correlate eleven distinct commensal bacteria at our vivarium with the severity of ALS in mice, and by their individual supplementation into antibiotic-treated Sod1-Tg mice we demonstrate that Akkermansia muciniphila (AM) ameliorates whereas Ruminococcus torques and Parabacteroides distasonis exacerbate the symptoms of ALS. Furthermore, Sod1-Tg mice that are administered AM are found to accumulate AM-associated nicotinamide in the central nervous system, and systemic supplementation of nicotinamide improves motor symptoms and gene expression patterns in the spinal cord of Sod1-Tg mice. In humans, we identify distinct microbiome and metabolite configurations-including reduced levels of nicotinamide systemically and in the cerebrospinal fluid-in a small preliminary study that compares patients with ALS with household controls. We suggest that environmentally driven microbiome-brain interactions may modulate ALS in mice, and we call for similar investigations in the human form of the disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- transgenic mouse model
- alignment
- nrf-1
- degeneration
- protects
- genes
- Science & Technology - Other Topics
Publication and Content Type
- ref (subject category)
- art (subject category)
- 1 of 92
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Blacher, E.
- Bashiardes, S.
- Shapiro, H.
- Rothschild, D.
- Mor, U.
- Dori-Bachash, M.
- show more...
- Kleimeyer, C.
- Moresi, C.
- Harnik, Y.
- Zur, M.
- Zabari, M.
- Brik, R. B. Z.
- Kviatcovsky, D.
- Zmora, N.
- Cohen, Y.
- Bar, N.
- Levi, I.
- Amar, N.
- Mehlman, T.
- Brandis, A.
- Biton, I.
- Kuperman, Y.
- Tsoory, M.
- Alfahel, L.
- Harmelin, A.
- Schwartz, M.
- Israelson, A.
- Arike, Liisa
- Johansson, Malin ...
- Hansson, Gunnar ...
- Gotkine, M.
- Segal, E.
- Elinav, E.
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Cell and Molecul ...
- Articles in the publication
- Nature
- By the university
- University of Gothenburg
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
