A Population-Based Single Nucleotide Polymorphism Array Analysis of Genomic Aberrations in Younger Adult Acute Lymphoblastic Leukemia Patients

Dirse, Vaidas (author)

Bertasiute, Agne (author)

Gineikiene, Egle (author)

Zvirblis, Tadas (author)

Dambrauskiene, Ruta (author)

Gerbutavicius, Rolandas (author)

Juozaityte, Elona (author)

Malciute, Ligita (author)

Paulsson, Kajsa (author): Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine

Griskevicius, Laimonas (author)

(creator_code:org_t)

2015-02-23
2015
English.
In: Genes, Chromosomes and Cancer. - : Wiley. - 1045-2257. ; 54:5, s. 326-333

Related links:: http://dx.doi.org/10...; show more...; https://lup.lub.lu.s...; https://doi.org/10.1...; show less...

Abstract Subject headings

Adult acute lymphoblastic leukemia (ALL) is characterized by a high frequency of abnormal karyotypes some of which are related to outcome. Single nucleotide polymorphism (SNP) array analysis provides a highly sensitive platform to detect large and small genomic aberrations. SNP array profiling data in adult ALL are limited and further systematic studies of this patient group are needed. We performed a population-based SNP array analysis of genomic aberrations and their influence on survival in 66 Lithuanian 18-65 year old ALL patients diagnosed between 2007 and 2013. Most aberrations were detected in chromosome arm 9p, chromosome arm 6q, chromosome arm 13q, and chromosome 17. The recurrently targeted copy number abnormalities involved several leukemia-related genesCDKN2A/B, MLL, IKZF1, PAX5, RB1, TP53, and ETV6. We identified several new recurrent aberrations with possible new target genes: SMARCA4 in 19p13.2, RNASEL in 1q25.3, ARHGEF12 in 11q23.3, and LYL1 in 19p13.2. Aberrations in chromosome 13 and the RB1 gene as well as CDKN2A/B gene status were related to the outcome. (c) 2015 Wiley Periodicals, Inc.

By the author/editor: Dirse, Vaidas; Bertasiute, Agne; Gineikiene, Egle; Zvirblis, Tadas; Dambrauskiene, R ...; Gerbutavicius, R ...; show more...; Juozaityte, Elon ...; Malciute, Ligita; Paulsson, Kajsa; Griskevicius, La ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

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