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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006090naa a2201045 4500
001oai:gup.ub.gu.se/323166
003SwePub
008240528s2022 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/3231662 URI
0247 a https://doi.org/10.3389/fpsyg.2022.9573082 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Kleineidam, Luca4 aut
2451 0a Midlife occupational cognitive requirements protect cognitive function in old age by increasing cognitive reserve
264 c 2022-12-08
264 1b Frontiers Media SA,c 2022
520 a Introduction: Several lifestyle factors promote protection against Alzheimer's disease (AD) throughout a person's lifespan. Although such protective effects have been described for occupational cognitive requirements (OCR) in midlife, it is currently unknown whether they are conveyed by brain maintenance (BM), brain reserve (BR), or cognitive reserve (CR) or a combination of them. Methods: We systematically derived hypotheses for these resilience concepts and tested them in the population-based AgeCoDe cohort and memory clinic-based AD high-risk DELCODE study. The OCR score (OCRS) was measured using job activities based on the O*NET occupational classification system. Four sets of analyses were conducted: (1) the interaction of OCR and APOE-ε4 with regard to cognitive decline (N = 2,369, AgeCoDe), (2) association with differentially shaped retrospective trajectories before the onset of dementia of the Alzheimer's type (DAT; N = 474, AgeCoDe), (3) cross-sectional interaction of the OCR and cerebrospinal fluid (CSF) AD biomarkers and brain structural measures regarding memory function (N = 873, DELCODE), and (4) cross-sectional and longitudinal association of OCR with CSF AD biomarkers and brain structural measures (N = 873, DELCODE). Results: Regarding (1), higher OCRS was associated with a reduced association of APOE-ε4 with cognitive decline (mean follow-up = 6.03 years), consistent with CR and BR. Regarding (2), high OCRS was associated with a later onset but subsequently stronger cognitive decline in individuals converting to DAT, consistent with CR. Regarding (3), higher OCRS was associated with a weaker association of the CSF Aβ42/40 ratio and hippocampal volume with memory function, consistent with CR. Regarding (4), OCR was not associated with the levels or changes in CSF AD biomarkers (mean follow-up = 2.61 years). We found a cross-sectional, age-independent association of OCRS with some MRI markers, but no association with 1-year-change. OCR was not associated with the intracranial volume. These results are not completely consistent with those of BR or BM. Discussion: Our results support the link between OCR and CR. Promoting and seeking complex and stimulating work conditions in midlife could therefore contribute to increased resistance to pathologies in old age and might complement prevention measures aimed at reducing pathology.
650 7a SAMHÄLLSVETENSKAPx Psykologi0 (SwePub)5012 hsv//swe
650 7a SOCIAL SCIENCESx Psychology0 (SwePub)5012 hsv//eng
653 a Alzheimer's disease
653 a brain maintenance
653 a brain reserve
653 a cognitive reserve
653 a mid-life cognitive demands
653 a occupation
7001 a Wolfsgruber, Steffen4 aut
7001 a Weyrauch, Anne Sophie4 aut
7001 a Zulka, Linn Elena,d 1992u Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Centrum för åldrande och hälsa (AgeCap),Department of Psychology,Centre for Ageing and Health (Agecap)4 aut0 (Swepub:gu)xzulli
7001 a Forstmeier, Simon4 aut
7001 a Roeske, Sandra4 aut
7001 a van den Bussche, Hendrik4 aut
7001 a Kaduszkiewicz, Hanna4 aut
7001 a Wiese, Birgitt4 aut
7001 a Weyerer, Siegfried4 aut
7001 a Werle, Jochen4 aut
7001 a Fuchs, Angela4 aut
7001 a Pentzek, Michael4 aut
7001 a Brettschneider, Christian4 aut
7001 a König, Hans Helmut4 aut
7001 a Weeg, Dagmar4 aut
7001 a Bickel, Horst4 aut
7001 a Luppa, Melanie4 aut
7001 a Rodriguez, Francisca S.4 aut
7001 a Freiesleben, Silka Dawn4 aut
7001 a Erdogan, Selin4 aut
7001 a Unterfeld, Chantal4 aut
7001 a Peters, Oliver4 aut
7001 a Spruth, Eike J.4 aut
7001 a Altenstein, Slawek4 aut
7001 a Lohse, Andrea4 aut
7001 a Priller, Josef4 aut
7001 a Fliessbach, Klaus4 aut
7001 a Kobeleva, Xenia4 aut
7001 a Schneider, Anja4 aut
7001 a Bartels, Claudia4 aut
7001 a Schott, Björn H.4 aut
7001 a Wiltfang, Jens4 aut
7001 a Maier, Franziska4 aut
7001 a Glanz, Wenzel4 aut
7001 a Incesoy, Enise I.4 aut
7001 a Butryn, Michaela4 aut
7001 a Düzel, Emrah4 aut
7001 a Buerger, Katharina4 aut
7001 a Janowitz, Daniel4 aut
7001 a Ewers, Michael4 aut
7001 a Rauchmann, Boris Stephan4 aut
7001 a Perneczky, Robert4 aut
7001 a Kilimann, Ingo4 aut
7001 a Görß, Doreen4 aut
7001 a Teipel, Stefan4 aut
7001 a Laske, Christoph4 aut
7001 a Munk, Matthias H.J.4 aut
7001 a Spottke, Annika4 aut
7001 a Roy, Nina4 aut
7001 a Brosseron, Frederic4 aut
7001 a Heneka, Michael T.4 aut
7001 a Ramirez, Alfredo4 aut
7001 a Yakupov, Renat4 aut
7001 a Scherer, Martin4 aut
7001 a Maier, Wolfgang4 aut
7001 a Jessen, Frank4 aut
7001 a Riedel-Heller, Steffi G.4 aut
7001 a Wagner, Michael4 aut
7102 a Göteborgs universitetb Psykologiska institutionen4 org
7730 t Frontiers in Psychologyd : Frontiers Media SAg 13q 13x 1664-1078
8564 8u https://gup.ub.gu.se/publication/323166
8564 8u https://doi.org/10.3389/fpsyg.2022.957308

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