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Genetic susceptibil...
Genetic susceptibility to postherniotomy pain. The influence of polymorphisms in the Mu opioid receptor, TNF-alpha, GRIK3, GCH1, BDNF and CACNA2D2 genes
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- Kalliomäki, Maija-Liisa (author)
- Uppsala universitet,Anestesiologi och intensivvård,Tampere Univ Hosp, Dept Anaesthesia, POB 2000, Tampere 33521, Finland
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- Sandblom, Gabriel (author)
- CLINTEC, Karolinska Inst, Stockholm, Sweden
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- Hallberg, Mathias, 1971- (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Biologisk beroendeforskning
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- Grönbladh, Alfhild (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Biologisk beroendeforskning
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- Gunarsson, Ulf (author)
- Umea Univ, Dept Surg & Perioperat Sci, S-90187 Umea, Sweden
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- Gordh, Torsten (author)
- Uppsala universitet,Anestesiologi och intensivvård,Univ Uppsala Hosp, Pain Ctr, Uppsala, Sweden
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- Ginya, Harumi (author)
- Precis Syst Sci Co Ltd, Div IVD Syst Dev, Chiba, Japan
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- Nyberg, Fred (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Biologisk beroendeforskning
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(creator_code:org_t)
- 2016-07-01
- 2016
- English.
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In: Scandinavian Journal of Pain. - : Walter de Gruyter GmbH. - 1877-8860 .- 1877-8879. ; 12, s. 1-6
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background and aims: Despite improvements in surgical technique, 5%-8% of patients undergoing herniorrhaphy still suffer from clinically relevant persistent postherniotomy pain. This is a problem at both individual and society levels. The aim of this study was to determine whether or not a single nucleotide polymorphism in a specific gene contributes to the development of persistent pain after surgery. Methods: One hundred individuals with persistent postherniotomy pain, along with 100 without pain matched for age, gender and type of surgery were identified in a previous cohort study on patients operated for groin hernia. All patients underwent a thorough sensory examination and blood samples were collected. DNA was extracted and analysed for single nucleotide polymorphism in the Mu opioid receptor, TNF-alpha, GRIK3, GCH1, BDNF and CACNA2D2 genes. Results: Patients with neuropathic pain were found to have a homozygous single nucleotide polymorph in the TNF-alpha gene significantly more often than pain-free patients (P = 0.036, one-tailed test). Conclusions: SNP in the TNF-alpha gene has a significant impact on the risk for developing PPSP. Implications: The result suggests the involvement of genetic variance in the development of pain and this requires further investigation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Persistent postsurgical pain
- Single nucleotide polymorphism
- Genetic variance
- TNF-alpha
- Groin hernia
Publication and Content Type
- ref (subject category)
- art (subject category)
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