WFRF:(Kalsi G.)
Sökning: WFRF:(Kalsi G.) > (2005-2009) > Meta-analysis of 32...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05914naa a2201381 4500 | |
| 001 | oai:DiVA.org:uu-120061 | |
| 003 | SwePub | |
| 008 | 100305s2009 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:119104405 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1200612 URI |
| 024 | 7 | a https://doi.org/10.1038/mp.2008.1352 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1191044052 URI |
| 040 | a (SwePub)uud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Ng, M Y M4 aut |
| 245 | 1 0 | a Meta-analysis of 32 genome-wide linkage studies of schizophrenia |
| 264 | c 2008-12-30 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2009 |
| 338 | a print2 rdacarrier | |
| 520 | a A genome scan meta-analysis (GSMA) was carried out on 32 independent genome-wide linkage scan analyses that included 3255 pedigrees with 7413 genotyped cases affected with schizophrenia (SCZ) or related disorders. The primary GSMA divided the autosomes into 120 bins, rank-ordered the bins within each study according to the most positive linkage result in each bin, summed these ranks (weighted for study size) for each bin across studies and determined the empirical probability of a given summed rank (P(SR)) by simulation. Suggestive evidence for linkage was observed in two single bins, on chromosomes 5q (142-168 Mb) and 2q (103-134 Mb). Genome-wide evidence for linkage was detected on chromosome 2q (119-152 Mb) when bin boundaries were shifted to the middle of the previous bins. The primary analysis met empirical criteria for 'aggregate' genome-wide significance, indicating that some or all of 10 bins are likely to contain loci linked to SCZ, including regions of chromosomes 1, 2q, 3q, 4q, 5q, 8p and 10q. In a secondary analysis of 22 studies of European-ancestry samples, suggestive evidence for linkage was observed on chromosome 8p (16-33 Mb). Although the newer genome-wide association methodology has greater power to detect weak associations to single common DNA sequence variants, linkage analysis can detect diverse genetic effects that segregate in families, including multiple rare variants within one locus or several weakly associated loci in the same region. Therefore, the regions supported by this meta-analysis deserve close attention in future studies. | |
| 653 | a genome | |
| 653 | a human | |
| 653 | a humans | |
| 653 | a schizophrenia/genetics | |
| 653 | a genetic predisposition to disease | |
| 653 | a linkage (genetics) | |
| 653 | a meta-analysis | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Levinson, D F4 aut |
| 700 | 1 | a Faraone, S V4 aut |
| 700 | 1 | a Suarez, B K4 aut |
| 700 | 1 | a DeLisi, L E4 aut |
| 700 | 1 | a Arinami, T4 aut |
| 700 | 1 | a Riley, B4 aut |
| 700 | 1 | a Paunio, T4 aut |
| 700 | 1 | a Pulver, A E4 aut |
| 700 | 1 | a Holmans, P A4 aut |
| 700 | 1 | a Escamilla, M4 aut |
| 700 | 1 | a Wildenauer, D B4 aut |
| 700 | 1 | a Williams, N M4 aut |
| 700 | 1 | a Laurent, C4 aut |
| 700 | 1 | a Mowry, B J4 aut |
| 700 | 1 | a Brzustowicz, L M4 aut |
| 700 | 1 | a Maziade, M4 aut |
| 700 | 1 | a Sklar, P4 aut |
| 700 | 1 | a Garver, D L4 aut |
| 700 | 1 | a Abecasis, G R4 aut |
| 700 | 1 | a Lerer, B4 aut |
| 700 | 1 | a Fallin, M D4 aut |
| 700 | 1 | a Gurling, H M D4 aut |
| 700 | 1 | a Gejman, P V4 aut |
| 700 | 1 | a Lindholm, Eu Uppsala universitet,Zoologisk utvecklingsbiologi4 aut |
| 700 | 1 | a Moises, H W4 aut |
| 700 | 1 | a Byerley, W4 aut |
| 700 | 1 | a Wijsman, E M4 aut |
| 700 | 1 | a Forabosco, P4 aut |
| 700 | 1 | a Tsuang, M T4 aut |
| 700 | 1 | a Hwu, H-G4 aut |
| 700 | 1 | a Okazaki, Y4 aut |
| 700 | 1 | a Kendler, K S4 aut |
| 700 | 1 | a Wormley, B4 aut |
| 700 | 1 | a Fanous, A4 aut |
| 700 | 1 | a Walsh, D4 aut |
| 700 | 1 | a O'Neill, F A4 aut |
| 700 | 1 | a Peltonen, L4 aut |
| 700 | 1 | a Nestadt, G4 aut |
| 700 | 1 | a Lasseter, V K4 aut |
| 700 | 1 | a Liang, K Y4 aut |
| 700 | 1 | a Papadimitriou, G M4 aut |
| 700 | 1 | a Dikeos, D G4 aut |
| 700 | 1 | a Schwab, S G4 aut |
| 700 | 1 | a Owen, M J4 aut |
| 700 | 1 | a O'Donovan, M C4 aut |
| 700 | 1 | a Norton, N4 aut |
| 700 | 1 | a Hare, E4 aut |
| 700 | 1 | a Raventos, H4 aut |
| 700 | 1 | a Nicolini, H4 aut |
| 700 | 1 | a Albus, M4 aut |
| 700 | 1 | a Maier, W4 aut |
| 700 | 1 | a Nimgaonkar, V L4 aut |
| 700 | 1 | a Terenius, Lu Karolinska Institutet4 aut |
| 700 | 1 | a Mallet, J4 aut |
| 700 | 1 | a Jay, M4 aut |
| 700 | 1 | a Godard, S4 aut |
| 700 | 1 | a Nertney, D4 aut |
| 700 | 1 | a Alexander, M4 aut |
| 700 | 1 | a Crowe, R R4 aut |
| 700 | 1 | a Silverman, J M4 aut |
| 700 | 1 | a Bassett, A S4 aut |
| 700 | 1 | a Roy, M-A4 aut |
| 700 | 1 | a Mérette, C4 aut |
| 700 | 1 | a Pato, C N4 aut |
| 700 | 1 | a Pato, M T4 aut |
| 700 | 1 | a Roos, J Louw4 aut |
| 700 | 1 | a Kohn, Y4 aut |
| 700 | 1 | a Amann-Zalcenstein, D4 aut |
| 700 | 1 | a Kalsi, G4 aut |
| 700 | 1 | a McQuillin, A4 aut |
| 700 | 1 | a Curtis, D4 aut |
| 700 | 1 | a Brynjolfson, J4 aut |
| 700 | 1 | a Sigmundsson, T4 aut |
| 700 | 1 | a Petursson, H4 aut |
| 700 | 1 | a Sanders, A R4 aut |
| 700 | 1 | a Duan, J4 aut |
| 700 | 1 | a Jazin, Eu Uppsala universitet,Zoologisk utvecklingsbiologi4 aut |
| 700 | 1 | a Myles-Worsley, M4 aut |
| 700 | 1 | a Karayiorgou, M4 aut |
| 700 | 1 | a Lewis, C M4 aut |
| 710 | 2 | a Uppsala universitetb Zoologisk utvecklingsbiologi4 org |
| 773 | 0 | t Molecular Psychiatryd : Springer Science and Business Media LLCg 14:8, s. 774-785q 14:8<774-785x 1359-4184x 1476-5578 |
| 856 | 4 | u https://www.nature.com/articles/mp2008135.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-120061 |
| 856 | 4 8 | u https://doi.org/10.1038/mp.2008.135 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:119104405 |
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- Ng, M Y M
- Levinson, D F
- Faraone, S V
- Suarez, B K
- DeLisi, L E
- Arinami, T
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- Riley, B
- Paunio, T
- Pulver, A E
- Holmans, P A
- Escamilla, M
- Wildenauer, D B
- Williams, N M
- Laurent, C
- Mowry, B J
- Brzustowicz, L M
- Maziade, M
- Sklar, P
- Garver, D L
- Abecasis, G R
- Lerer, B
- Fallin, M D
- Gurling, H M D
- Gejman, P V
- Lindholm, E
- Moises, H W
- Byerley, W
- Wijsman, E M
- Forabosco, P
- Tsuang, M T
- Hwu, H-G
- Okazaki, Y
- Kendler, K S
- Wormley, B
- Fanous, A
- Walsh, D
- O'Neill, F A
- Peltonen, L
- Nestadt, G
- Lasseter, V K
- Liang, K Y
- Papadimitriou, G ...
- Dikeos, D G
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- Owen, M J
- O'Donovan, M C
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- Maier, W
- Nimgaonkar, V L
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- Godard, S
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- Kalsi, G
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