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EULAR recommendatio...
EULAR recommendations for the management of ANCA-associated vasculitis : 2022 update
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- Hellmich, Bernhard (författare)
- University of Tübingen
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Sanchez-Alamo, Beatriz (författare)
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- Schirmer, Jan H. (författare)
- University Medical Center Schleswig-Holstein
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visa fler...
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- Berti, Alvise (författare)
- University of Trento,Santa Chiara Hospital, Trento
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- Blockmans, Daniel (författare)
- University Hospitals Leuven
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- Cid, Maria C. (författare)
- University of Barcelona
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- Holle, Julia U. (författare)
- Rheumazentrum Schleswig-Holstein Mitte
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- Hollinger, Nicole (författare)
- University of Tübingen
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- Karadag, Omer (författare)
- Hacettepe University
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- Kronbichler, Andreas (författare)
- Medical University of Innsbruck
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- Little, Mark A. (författare)
- Trinity College Dublin
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- Luqmani, Raashid A. (författare)
- University of Oxford
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- Mahr, Alfred (författare)
- Kantonsspital St Gallen
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- Merkel, Peter A. (författare)
- Hospital of the University of Pennsylvania
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- Mohammad, Aladdin J. (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,University of Cambridge,Skåne University Hospital
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- Monti, Sara (författare)
- Policlinico San Matteo Pavia Fondazione,University of Pavia
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- Mukhtyar, Chetan B. (författare)
- Norfolk and Norwich University Hospital NHS Trust
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- Musial, Jacek (författare)
- Jagiellonian University
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Price-Kuehne, Fiona (författare)
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- Segelmark, Mårten (författare)
- Lund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Teng, Y. K.Onno (författare)
- Leiden University Medical Centre
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- Terrier, Benjamin (författare)
- Cochin Hospital
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- Tomasson, Gunnar (författare)
- National University Hospital of Iceland
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- Vaglio, Augusto (författare)
- Meyer Children's Hospital
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- Vassilopoulos, Dimitrios (författare)
- National and Kapodistrian University of Athens
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Verhoeven, Peter (författare)
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Jayne, David (författare)
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(creator_code:org_t)
- 2023-03-16
- 2024
- Engelska.
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Ingår i: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967 .- 1468-2060. ; 83:1, s. 30-47
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Since the publication of the EULAR recommendations for the management of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in 2016, several randomised clinical trials have been published that have the potential to change clinical care and support the need for an update. Methods: Using EULAR standardised operating procedures, the EULAR task force undertook a systematic literature review and sought opinion from 20 experts from 16 countries. We modified existing recommendations and created new recommendations. Results: Four overarching principles and 17 recommendations were formulated. We recommend biopsies and ANCA testing to assist in establishing a diagnosis of AAV. For remission induction in life-threatening or organ-threatening AAV, we recommend a combination of high-dose glucocorticoids (GCs) in combination with either rituximab or cyclophosphamide. We recommend tapering of the GC dose to a target of 5 mg prednisolone equivalent/day within 4-5 months. Avacopan may be considered as part of a strategy to reduce exposure to GC in granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA). Plasma exchange may be considered in patients with rapidly progressive glomerulonephritis. For remission maintenance of GPA/MPA, we recommend rituximab. In patients with relapsing or refractory eosinophilic GPA, we recommend the use of mepolizumab. Azathioprine and methotrexate are alternatives to biologics for remission maintenance in AAV. Conclusions: In the light of recent advancements, these recommendations provide updated guidance on AAV management. As substantial data gaps still exist, informed decision-making between physicians and patients remains of key relevance.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- cyclophosphamide
- granulomatosis with polyangiitis
- rituximab
- systemic vasculitis
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- ref (ämneskategori)
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- Av författaren/redakt...
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Hellmich, Bernha ...
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Sanchez-Alamo, B ...
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Schirmer, Jan H.
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Berti, Alvise
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Blockmans, Danie ...
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Cid, Maria C.
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visa fler...
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Holle, Julia U.
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Hollinger, Nicol ...
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Karadag, Omer
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Kronbichler, And ...
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Little, Mark A.
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Luqmani, Raashid ...
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Mahr, Alfred
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Merkel, Peter A.
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Mohammad, Aladdi ...
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Monti, Sara
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Mukhtyar, Chetan ...
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Musial, Jacek
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Price-Kuehne, Fi ...
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Segelmark, Mårte ...
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Teng, Y. K.Onno
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Terrier, Benjami ...
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Tomasson, Gunnar
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Vaglio, Augusto
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Vassilopoulos, D ...
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Verhoeven, Peter
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Jayne, David
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visa färre...
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