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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004873naa a2200577 4500
001oai:lup.lub.lu.se:77102f37-8032-48f2-a4f3-d6469c83ca21
003SwePub
008191206s2020 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/77102f37-8032-48f2-a4f3-d6469c83ca212 URI
0247 a https://doi.org/10.1007/s11682-019-00198-12 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Rauchmann, Boris Stephanu Ludwig-Maximilian University of Munich4 aut
2451 0a The impact of endurance training and table soccer on brain metabolites in schizophrenia
264 c 2019-11-05
264 1b Springer Science and Business Media LLC,c 2020
300 a 12 s.
520 a Higher glutamate and glutamine (together: Glx) and lower N-acetyl-aspartate (NAA) levels were reported in schizophrenia. Endurance training normalizes NAA in the hippocampus, but its effects on other metabolites in the brain and the relationship of metabolites to clinical symptoms remain unknown. For 12 weeks, 20 schizophrenia inpatients (14 men, 6 women) and 23 healthy controls (16 men, 7 women) performed endurance training and a control group of 21 schizophrenia inpatients (15 men, 6 women) played table soccer. A computer-assisted cognitive performance training program was introduced after 6 weeks. We assessed cognitive performance, psychopathological symptoms, and everyday functioning at baseline and after 6 and 12 weeks and performed single voxel magnetic resonance spectroscopy of the hippocampus, left dorsolateral prefrontal cortex (DLPFC), and thalamus. We quantified NAA, Glx, total creatine (tCr), calculated NAA/tCr and Glx/tCr and correlated these ratios with physical fitness, clinical and neurocognitive scores, and everyday functioning. At baseline, in both schizophrenia groups NAA/tCr was lower in the left DLPFC and left hippocampus and Glx/tCr was lower in the hippocampus than in the healthy controls. After 6 weeks, NAA/tCr increased in the left DLPFC in both schizophrenia groups. Brain metabolites did not change significantly in the hippocampus or thalamus, but the correlation between NAA/tCr and Glx/tCr normalized in the left DLPFC. Global Assessment of Functioning improvements correlated with NAA/tCr changes in the left DLPFC. In our study, endurance training and table soccer induced normalization of brain metabolite ratios in the brain circuitry associated with neuronal and synaptic elements, including metabolites of the glutamatergic system.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
650 7a NATURVETENSKAPx Fysikx Annan fysik0 (SwePub)103992 hsv//swe
650 7a NATURAL SCIENCESx Physical Sciencesx Other Physics Topics0 (SwePub)103992 hsv//eng
653 a Aerobic exercise
653 a Clinical symptoms
653 a Glx
653 a MRS
653 a NAA
653 a Schizophrenia
7001 a Ghaseminejad, Farhadu University of British Columbia4 aut
7001 a Keeser, Danielu Ludwig-Maximilian University of Munich4 aut
7001 a Keller-Varady, Katrionau Ludwig-Maximilian University of Munich4 aut
7001 a Schneider-Axmann, Thomasu Ludwig-Maximilian University of Munich4 aut
7001 a Takahashi, Shunu Wakayama Medical College,Ludwig-Maximilian University of Munich4 aut
7001 a Karali, Temmuzu Ludwig-Maximilian University of Munich4 aut
7001 a Helms, Guntheru Lund University,Lunds universitet,MR Physics,Forskargrupper vid Lunds universitet,Lund University Research Groups4 aut0 (Swepub:lu)med-guh
7001 a Dechent, Peteru University Medical Center Göttingen4 aut
7001 a Maurus, Isabelu Ludwig-Maximilian University of Munich4 aut
7001 a Hasan, Alkomietu Ludwig-Maximilian University of Munich4 aut
7001 a Wobrock, Thomasu University of Göttingen4 aut
7001 a Ertl-Wagner, Birgitu Hospital for Sick Children, Toronto,Ludwig-Maximilian University of Munich4 aut
7001 a Schmitt, Andreau University of São Paulo,Ludwig-Maximilian University of Munich4 aut
7001 a Malchow, Berendu Universitätsklinikum Jena4 aut
7001 a Falkai, Peteru Ludwig-Maximilian University of Munich4 aut
7102 a Ludwig-Maximilian University of Munichb University of British Columbia4 org
7730 t Brain Imaging and Behaviord : Springer Science and Business Media LLCg 14:2, s. 515-526q 14:2<515-526x 1931-7557x 1931-7565
8564 u http://dx.doi.org/10.1007/s11682-019-00198-1y FULLTEXT
8564 8u https://lup.lub.lu.se/record/77102f37-8032-48f2-a4f3-d6469c83ca21
8564 8u https://doi.org/10.1007/s11682-019-00198-1

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